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Biology and Biochemistry

D-Index
70
Citations
13519
World Ranking
7180
National Ranking
487

Overview

Akira Nakai is affiliated with Yamaguchi University in Japan. Their primary research fields include Biochemistry, Genetics and Molecular Biology, with notable contributions also in Medicine. Subfields of their work concentrate on Molecular Biology, Cell Biology, Pulmonary and Respiratory Medicine, Physical and Theoretical Chemistry, and Aging.

The scientist's research covers a variety of topics, with a focus on heat shock proteins research, endoplasmic reticulum stress and disease, ferroptosis and cancer prognosis, thermodynamics and calorimetric analyses, RNA research and splicing, genetics, aging, and longevity in model organisms, as well as natural compounds in disease treatment.

Frequent collaborators in their research include Mitsuaki Fujimoto, Ryosuke Takii, Mariko Okada, Ke Tan, and Pratibha Srivastava.

Publications by Akira Nakai have appeared predominantly in the following venues:

  • FEBS Letters
  • Molecular Oncology
  • British Journal of Pharmacology
  • FEBS Open Bio
  • Nature Communications

Significant recent papers by the scientist include:

  • "Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis," 2021, Molecular Oncology
  • "Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis," 2021, British Journal of Pharmacology
  • "HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response," 2020, FEBS Open Bio
  • "HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis," 2022, Nature Communications
  • "The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells," 2023, FEBS Letters

Best Publications

  • PDSM, a motif for phosphorylation-dependent SUMO modification.

    Ville Hietakangas;Julius Anckar;Henri A. Blomster;Mitsuaki Fujimoto

  • The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State

    G. Enrico Rovati;Valérie Capra;Richard R. Neubig

  • HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator.

    A Nakai;M Tanabe;Y Kawazoe;J Inazawa

  • Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.

    Akira Nakai;Richard I Morimoto

  • Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta

    Akihiro Sakurai;Kyoko Takeda;Kenneth Ain;Paola Ceccarelli

  • Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum.

    Akira Nakai;Mamoru Satoh;Kazunori Hirayoshi;Kazuhiro Nagata

  • HSF4 is required for normal cell growth and differentiation during mouse lens development

    Mitsuaki Fujimoto;Hanae Izu;Keisuke Seki;Ken Fukuda

  • The heat shock factor family and adaptation to proteotoxic stress.

    Mitsuaki Fujimoto;Akira Nakai

  • Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.

    Mitsuaki Fujimoto;Eiichi Takaki;Tetsuya Hayashi;Yasushi Kitaura

  • Flavonoids inhibit the expression of heat shock proteins

    Nobuko Hosokawa;Kazunori Hirayoshi;Akira Nakai;Ydhei Hosokawa

  • Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1

    Akira Nakai;Misao Suzuki;Masako Tanabe;Masako Tanabe

  • Long-term Melatonin Treatment Delays Ovarian Aging

    Hiroshi Tamura;Mai Kawamoto;Shun Sato;Isao Tamura

  • Quercetin suppresses heat shock response by down regulation of HSF1.

    N. Nagai;A. Nakai;K. Nagata

  • Proteasome inhibition leads to the activation of all members of the heat-shock-factor family.

    Yoshinori Kawazoe;Akira Nakai;Masako Tanabe;Kazuhiro Nagata

  • The Mammalian HSF4 Gene Generates Both an Activator and a Repressor of Heat Shock Genes by Alternative Splicing

    Masako Tanabe;Noriaki Sasai;Kazuhiro Nagata;Kazuhiro Nagata;Xiao-Dong Liu

  • Cloning and expression of murine high molecular mass heat shock proteins, HSP105.

    Kunihiko Yasuda;Akira Nakai;Takumi Hatayama;Kazuhiro Nagata

  • Genetic Evidence for a Protective Role for Heat Shock Factor 1 and Heat Shock Protein 70 against Colitis

    Ken Ichiro Tanaka;Takushi Namba;Yasuhiro Arai;Mitsuaki Fujimoto

  • HSP47: a Tissue-Specific, Transformation-Sensitive, Collagen-Binding Heat Shock Protein of Chicken Embryo Fibroblasts.

    Kazunori Hirayoshi;Hitoshi Kudo;Hajime Takechi;Akira Nakai

  • Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance

    Masako Tanabe;Yoshinori Kawazoe;Shunichi Takeda;Richard I. Morimoto

  • Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart

    Junichiro Nishizawa;Akira Nakai;Katsuhiko Matsuda;Masashi Komeda

Frequent Co-Authors

Kazuhiro Nagata
Kazuhiro Nagata Kyoto Sangyo University
Issei Komuro
Issei Komuro University of Tokyo
Richard I. Morimoto
Richard I. Morimoto Northwestern University
Leslie J. DeGroot
Leslie J. DeGroot University of Chicago
Hiroyoshi Hidaka
Hiroyoshi Hidaka D. Western Therapeutics Institute (Japan)
Norihiro Sugino
Norihiro Sugino Yamaguchi University
Tohru Mizushima
Tohru Mizushima Keio University
Kristen J. Brennand
Kristen J. Brennand Icahn School of Medicine at Mount Sinai
Hiroaki Adachi
Hiroaki Adachi University of East Anglia
Gen Sobue
Gen Sobue Aichi Medical University

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