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Biology and Biochemistry

D-Index
59
Citations
17879
World Ranking
12318
National Ranking
5273

Overview

Kalpana Ghoshal is affiliated with The Ohio State University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, they focus on several subfields including Molecular Biology, Cancer Research, Oncology, Epidemiology, and Hepatology.

The scientist's work covers diverse topics such as RNA modifications and cancer, microRNA in disease regulation, cancer-related molecular mechanisms research, epigenetics and DNA methylation, cancer, hypoxia, and metabolism, protein degradation and inhibitors, and hepatitis B virus studies.

Selected recent publications include:

  • Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma, 2020, published in Cancers
  • Regulation of hepatic glutamine metabolism by miR-122, 2020, published in Molecular Metabolism
  • Hypoxia-inducible factor-1α-dependent induction of miR122 enhances hepatic ischemia tolerance, 2021, published in Journal of Clinical Investigation
  • METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice, 2021, published in American Journal Of Pathology
  • Intra-Tumoral Delivery of IL-27 Using Adeno-Associated Virus Stimulates Anti-tumor Immunity and Enhances the Efficacy of Immunotherapy, 2020, published in Frontiers in Cell and Developmental Biology

Some of the most frequent publication venues for their work are Cancer Research, American Journal Of Pathology, Frontiers in Cell and Developmental Biology, Journal of Clinical Oncology, and Cancers.

They collaborate regularly with several researchers. Frequent co-authors include:

  • Samson T. Jacob
  • Huban Kutay
  • Lianbo Yu
  • Juan M. Barajas
  • Cho-Hao Lin

Best Publications

  • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

    Fanyin Meng;Roger Henson;Hania Wehbe-Janek;Kalpana Ghoshal

  • MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

    Tyler E. Miller;Kalpana Ghoshal;Bhuvaneswari Ramaswamy;Satavisha Roy

  • Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

    Shu Hao Hsu;Bo Wang;Janaiah Kota;Jianhua Yu

  • Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas

    Huban Kutay;Shoumei Bai;Jharna Datta;Tasneem Motiwala

  • MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib

    Shoumei Bai;Mohd W. Nasser;Bo Wang;Shu Hao Hsu

  • 5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal

    Kalpana Ghoshal;Jharna Datta;Sarmila Majumder;Shoumei Bai

  • mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues.

    Stephen W. Eichhorn;Huili Guo;Sean E. McGeary;Ricard A. Rodriguez-Mias

  • Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

    Jharna Datta;Huban Kutay;Mohd W. Nasser;Gerard J. Nuovo

  • CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

    Jianhong Chu;Youcai Deng;Don M. Benson;Shun He

  • TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

    Bo Wang;Shu-Hao Hsu;Sarmila Majumder;Huban Kutay

  • Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer SUPPRESSION OF TUMORIGENIC PROPERTY OF LUNG CANCER CELLS AND THEIR SENSITIZATION TO DOXORUBICIN-INDUCED APOPTOSIS BY miR-1

    Mohd W. Nasser;Jharna Datta;Gerard Nuovo;Huban Kutay

  • Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.

    Bo Wang;Sarmila Majumder;Gerard Nuovo;Huban Kutay

  • A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.

    Jharna Datta;Kalpana Ghoshal;William A. Denny;Swarna A. Gamage

  • Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.

    Bo Wang;Shu-Hao Hsu;Wendy Frankel;Kalpana Ghoshal

  • miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir.

    Sharda Thakral;Kalpana Ghoshal

  • A Folate- and Methyl-Deficient Diet Alters the Expression of DNA Methyltransferases and Methyl CpG Binding Proteins Involved in Epigenetic Gene Silencing in Livers of F344 Rats

    Kalpana Ghoshal;Xin Li;Jharna Datta;Shoumei Bai

  • Role of Human Ribosomal RNA (rRNA) Promoter Methylation and of Methyl-CpG-binding Protein MBD2 in the Suppression of rRNA Gene Expression

    Kalpana Ghoshal;Sarmila Majumder;Jharna Datta;Tasneem Motiwala

  • Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

    Kalpana Ghoshal;Jharna Datta;Sarmila Majumder;Shoumei Bai

  • An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

    Kalpana Ghoshal;Samson T. Jacob

  • Regulation of metallothionein gene expression.

    Kalpana Ghoshal;Samson T Jacob

Frequent Co-Authors

Samson T. Jacob
Samson T. Jacob The Ohio State University
Jianhua Yu
Jianhua Yu City Of Hope National Medical Center
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Gerard J. Nuovo
Gerard J. Nuovo The Ohio State University
Christoph Plass
Christoph Plass German Cancer Research Center
Saul Suster
Saul Suster Medical College of Wisconsin
Yong Peng
Yong Peng Sichuan University
L. James Lee
L. James Lee The Ohio State University
Bo Yu
Bo Yu Chinese Academy of Sciences
Robert J. Lee
Robert J. Lee University of Pennsylvania

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