D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 61 Citations 13,199 161 World Ranking 7428 National Ranking 561

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • DNA

Brian Burchell spends much of his time researching Biochemistry, Glucuronidation, Microsome, Bilirubin and Complementary DNA. His Glucuronidation research is multidisciplinary, incorporating elements of Glucuronosyltransferase, Isozyme, Xenobiotic and Metabolism. His Microsome research includes themes of Glucose 6-phosphatase and Pharmacology.

His Bilirubin research incorporates elements of Jaundice and Genotype. His work in Complementary DNA tackles topics such as Molecular biology which are related to areas like Molecular cloning, Amino acid, Recombinant DNA and Expression vector. His work on Divergent evolution and Subfamily as part of general Gene study is frequently linked to Gene nomenclature, bridging the gap between disciplines.

His most cited work include:

  • The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (944 citations)
  • Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (688 citations)
  • The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (383 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Biochemistry, Glucuronidation, Microsome, Enzyme and Bilirubin. Many of his studies involve connections with topics such as Molecular biology and Biochemistry. His work deals with themes such as Endocrinology, Internal medicine, Metabolism, Glucuronosyltransferase and Isozyme, which intersect with Glucuronidation.

Brian Burchell combines subjects such as Glucose 6-phosphatase, Chromatography and Enzyme inducer with his study of Microsome. In his work, Chemical synthesis is strongly intertwined with Stereochemistry, which is a subfield of Enzyme. Brian Burchell has included themes like Androsterone, Clofibrate, Kidney and Jaundice in his Bilirubin study.

He most often published in these fields:

  • Biochemistry (66.87%)
  • Glucuronidation (47.85%)
  • Microsome (37.42%)

What were the highlights of his more recent work (between 1999-2011)?

  • Glucuronidation (47.85%)
  • Biochemistry (66.87%)
  • Microsome (37.42%)

In recent papers he was focusing on the following fields of study:

Brian Burchell mainly investigates Glucuronidation, Biochemistry, Microsome, Glucuronosyltransferase and UGT2B7. His work carried out in the field of Glucuronidation brings together such families of science as Bilirubin, Endocrinology, Internal medicine, Metabolism and Isozyme. His research in Glucuronide, Enzyme, UGT1A6, Endoplasmic reticulum and Gene isoform are components of Biochemistry.

His Microsome research incorporates themes from Tolcapone, Metabolite, Pharmacology and Kidney metabolism. His biological study spans a wide range of topics, including Gunn rat, Uridine diphosphate, Genetic variation and Uridine diphosphate glucuronic acid. His UGT2B7 study integrates concerns from other disciplines, such as Xenobiotic glucuronidation, Kidney, Recombinant DNA and Steroid.

Between 1999 and 2011, his most popular works were:

  • Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (688 citations)
  • The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (383 citations)
  • In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance. (193 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • DNA

Brian Burchell focuses on Glucuronidation, Microsome, UGT2B7, Pharmacology and Biochemistry. The subject of his Glucuronidation research is within the realm of Genetics. In Microsome, Brian Burchell works on issues like Kidney metabolism, which are connected to Drug, In vitro, In vivo and Bilirubin.

He has researched UGT2B7 in several fields, including Pharmacokinetics, Internal medicine, Endocrinology and Non-competitive inhibition. His Pharmacology study incorporates themes from Cell, Reductase, Chinese hamster ovary cell and Cytotoxicity. In his research, Brian Burchell undertakes multidisciplinary study on Biochemistry and Valproic Acid.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

Peter I. Mackenzie;Ida S. Owens;Brian Burchell;K. W. Bock.
Pharmacogenetics (1997)

1305 Citations

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

Peter I Mackenzie;Karl Walter Bock;Brian Burchell;Chantal Guillemette.
Pharmacogenetics and Genomics (2005)

907 Citations

The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides.

Gabriele Jedlitschky;Brian Burchell;Dietrich Keppler.
Journal of Biological Chemistry (2000)

520 Citations

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2

Gabriele Jedlitschky;Inka Leier;Ulrike Buchholz;Johanna Hummel-Eisenbeiss.
Biochemical Journal (1997)

394 Citations

The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.

Brian Burchell;Daniel W. Nebert;David R. Nelson;Karl W. Bock.
DNA and Cell Biology (1991)

362 Citations

Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation.

Sahidan Senafi;D. J. Clarke;B. Burchell.
Biochemical Journal (1994)

339 Citations

UDP-glucuronosyltransferases: a family of detoxifying enzymes.

Thomas R. Tephly;Brian Burchell.
Trends in Pharmacological Sciences (1990)

328 Citations

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

M. W. H. Coughtrie;B. Burchell;J. E. A. Leakey;R. Hume.
Molecular Pharmacology (1988)

318 Citations

Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation.

Brian Burchell;Catherine H Brierley;David Rance.
Life Sciences (1995)

307 Citations

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance.

M. G. Soars;B. Burchell;R. J. Riley.
Journal of Pharmacology and Experimental Therapeutics (2002)

296 Citations

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