Brian Burchell spends much of his time researching Biochemistry, Glucuronidation, Microsome, Bilirubin and Complementary DNA. His Glucuronidation research is multidisciplinary, incorporating elements of Glucuronosyltransferase, Isozyme, Xenobiotic and Metabolism. His Microsome research includes themes of Glucose 6-phosphatase and Pharmacology.
His Bilirubin research incorporates elements of Jaundice and Genotype. His work in Complementary DNA tackles topics such as Molecular biology which are related to areas like Molecular cloning, Amino acid, Recombinant DNA and Expression vector. His work on Divergent evolution and Subfamily as part of general Gene study is frequently linked to Gene nomenclature, bridging the gap between disciplines.
His scientific interests lie mostly in Biochemistry, Glucuronidation, Microsome, Enzyme and Bilirubin. Many of his studies involve connections with topics such as Molecular biology and Biochemistry. His work deals with themes such as Endocrinology, Internal medicine, Metabolism, Glucuronosyltransferase and Isozyme, which intersect with Glucuronidation.
Brian Burchell combines subjects such as Glucose 6-phosphatase, Chromatography and Enzyme inducer with his study of Microsome. In his work, Chemical synthesis is strongly intertwined with Stereochemistry, which is a subfield of Enzyme. Brian Burchell has included themes like Androsterone, Clofibrate, Kidney and Jaundice in his Bilirubin study.
Brian Burchell mainly investigates Glucuronidation, Biochemistry, Microsome, Glucuronosyltransferase and UGT2B7. His work carried out in the field of Glucuronidation brings together such families of science as Bilirubin, Endocrinology, Internal medicine, Metabolism and Isozyme. His research in Glucuronide, Enzyme, UGT1A6, Endoplasmic reticulum and Gene isoform are components of Biochemistry.
His Microsome research incorporates themes from Tolcapone, Metabolite, Pharmacology and Kidney metabolism. His biological study spans a wide range of topics, including Gunn rat, Uridine diphosphate, Genetic variation and Uridine diphosphate glucuronic acid. His UGT2B7 study integrates concerns from other disciplines, such as Xenobiotic glucuronidation, Kidney, Recombinant DNA and Steroid.
Brian Burchell focuses on Glucuronidation, Microsome, UGT2B7, Pharmacology and Biochemistry. The subject of his Glucuronidation research is within the realm of Genetics. In Microsome, Brian Burchell works on issues like Kidney metabolism, which are connected to Drug, In vitro, In vivo and Bilirubin.
He has researched UGT2B7 in several fields, including Pharmacokinetics, Internal medicine, Endocrinology and Non-competitive inhibition. His Pharmacology study incorporates themes from Cell, Reductase, Chinese hamster ovary cell and Cytotoxicity. In his research, Brian Burchell undertakes multidisciplinary study on Biochemistry and Valproic Acid.
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The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
Peter I. Mackenzie;Ida S. Owens;Brian Burchell;K. W. Bock.
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Peter I Mackenzie;Karl Walter Bock;Brian Burchell;Chantal Guillemette.
Pharmacogenetics and Genomics (2005)
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides.
Gabriele Jedlitschky;Brian Burchell;Dietrich Keppler.
Journal of Biological Chemistry (2000)
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
Gabriele Jedlitschky;Inka Leier;Ulrike Buchholz;Johanna Hummel-Eisenbeiss.
Biochemical Journal (1997)
The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.
Brian Burchell;Daniel W. Nebert;David R. Nelson;Karl W. Bock.
DNA and Cell Biology (1991)
Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation.
Sahidan Senafi;D. J. Clarke;B. Burchell.
Biochemical Journal (1994)
UDP-glucuronosyltransferases: a family of detoxifying enzymes.
Thomas R. Tephly;Brian Burchell.
Trends in Pharmacological Sciences (1990)
The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.
M. W. H. Coughtrie;B. Burchell;J. E. A. Leakey;R. Hume.
Molecular Pharmacology (1988)
Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation.
Brian Burchell;Catherine H Brierley;David Rance.
Life Sciences (1995)
In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance.
M. G. Soars;B. Burchell;R. J. Riley.
Journal of Pharmacology and Experimental Therapeutics (2002)
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