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Molecular Biology

D-Index
79
Citations
19512
World Ranking
1049
National Ranking
33

Research.com Recognitions

  • 2001 - Fellow of the Royal Society of Canada Academy of Science

Overview

Jacques Drouin is affiliated with the University of Montreal in Canada and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research primarily focuses on Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics, Plant Science, and Clinical Psychology.

The scientist's work covers a variety of topics including:

  • Genomics and Chromatin Dynamics
  • Chromosomal and Genetic Variations
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Chromatin Remodeling and Cancer
  • Pituitary Gland Disorders and Treatments
  • Growth Hormone and Insulin-like Growth Factors

Drouin has published in several prominent venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • Nature Reviews Molecular Cell Biology
  • Nature Reviews Genetics

Recent publications include:

  • "Pioneer factors as master regulators of the epigenome and cell fate" (2022, Nature Reviews Molecular Cell Biology)
  • "Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors" (2021, Nature Communications)
  • "HOX13-dependent chromatin accessibility underlies the transition towards the digit development program" (2020, Nature Communications)
  • "Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics" (2020, Human Molecular Genetics)
  • "Pioneer factors - key regulators of chromatin and gene expression" (2023, Nature Reviews Genetics)

The scientist has collaborated frequently with Aurélio Balsalobre, Arthur Gouhier, Alexandre Mayran, Audrey Pelletier, and Juliette Harris.

Jacques Drouin was awarded the title of Fellow of the Royal Society of Canada in 2001 by the Academy of Science.

Best Publications

  • Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

    Hsin-Fang Yang-Yen;Jean-Claude Chambard;Yu-Lin Sun;Tod Smeal

  • Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

    T Lamonerie;J J Tremblay;C Lanctôt;M Therrien

  • A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins.

    Bruno Lamolet;Anne-Marie Pulichino;Thomas Lamonerie;Yves Gauthier

  • A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons

    Marten P. Smidt;Hermien S. A. van Schaick;Christian Lanctôt;Jacques J. Tremblay

  • The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3

    Jacques J. Tremblay;Christian Lanctôt;Jacques Drouin

  • Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells.

    A Philips;S Lesage;R Gingras;M H Maira

  • Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone β Gene Transcription

    Jacques J. Tremblay;Jacques Drouin

  • Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation.

    Mario Maira;Christine Martens;Alexandre Philips;Jacques Drouin

  • Different pattern of codon recognition by mammalian mitochondrial tRNAs.

    B. G. Barrell;Stephen Anderson;A. T. Bankier;M. H. de Bruijn

  • Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons.

    Pepijn van den Munckhof;Kelvin C. Luk;Line Ste-Marie;Jane Montgomery

  • Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription.

    J Drouin;M A Trifiro;R K Plante;M Nemer

  • Hindlimb patterning and mandible development require the Ptx1 gene.

    Christian Lanctôt;Alain Moreau;Michel Chamberland;Michel L. Tremblay

  • THE BICOID-RELATED HOMEOPROTEIN PTX1 DEFINES THE MOST ANTERIOR DOMAIN OF THE EMBRYO AND DIFFERENTIATES POSTERIOR FROM ANTERIOR LATERAL MESODERM

    C. Lanctot;B. Lamolet;J. Drouin

  • NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene.

    Gino Poulin;Benjamin Turgeon;Jacques Drouin

  • Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification.

    Hoonkyo Suh;Philip J. Gage;Jacques Drouin;Sally A. Camper

  • Tpit determines alternate fates during pituitary cell differentiation

    Anne-Marie Pulichino;Sophie Vallette-Kasic;Judy Peih-Ying Tsai;Catherine Couture

  • Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease

    Steve Bilodeau;Sophie Vallette-Kasic;Yves Gauthier;Dominique Figarella-Branger

  • Pioneer transcription factors shape the epigenetic landscape.

    Alexandre Mayran;Jacques Drouin

  • Antagonism between Nur77 and Glucocorticoid Receptor for Control of Transcription

    Alexandre Philips;Mario Maira;Alaka Mullick;Michel Chamberland

  • Pitx1 and Pitx2 are required for development of hindlimb buds.

    Alexandre Marcil;Émilie Dumontier;Michel Chamberland;Sally A. Camper

Frequent Co-Authors

Thierry Brue
Thierry Brue Aix-Marseille University
Mona Nemer
Mona Nemer University of Ottawa
Dominique Figarella-Branger
Dominique Figarella-Branger Aix-Marseille University
Fernand Labrie
Fernand Labrie Université Laval
Margaret Buckingham
Margaret Buckingham Institut Pasteur
Sally A. Camper
Sally A. Camper University of Michigan–Ann Arbor
Abbas F. Sadikot
Abbas F. Sadikot Montreal Neurological Institute and Hospital
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory
Martin Fassnacht
Martin Fassnacht University of Würzburg
Tomi Pastinen
Tomi Pastinen Children's Mercy Hospital

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