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Chemistry

D-Index
61
Citations
11722
World Ranking
9357
National Ranking
529

Biology and Biochemistry

D-Index
60
Citations
11435
World Ranking
12072
National Ranking
932

Research.com Recognitions

  • 2001 - Fellow of the Royal Society, United Kingdom

Overview

Thomas J. Simpson is affiliated with the University of Bristol in the United Kingdom. Their research primarily spans the field of Medicine with a focus on Pharmacology, Organic Chemistry, Materials Chemistry, Molecular Biology, and Plant Science as subfields.

Simpson's recent publications cover a range of topics primarily related to natural products, biosynthesis, and chemical biology. Notable papers include:

  • The 'emodin family' of fungal natural products-amalgamating a century of research with recent genomics-based advances, 2022, Natural Product Reports
  • The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI, 2020, Angewandte Chemie International Edition
  • Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics, 2020, Chemical Science
  • Uncovering biosynthetic relationships between antifungal nonadrides and octadrides, 2020, Chemical Science
  • VpROM: a novel variational autoencoder-boosted reduced order model for the treatment of parametric dependencies in nonlinear systems, 2024, Scientific Reports

Their work intersects themes such as microbial natural products and biosynthesis, fungal biology and applications, carbohydrate chemistry and synthesis, crystallization and solubility studies, and X-ray diffraction in crystallography. They have also contributed to research in areas including model reduction and neural networks as well as hydraulic and pneumatic systems.

Frequent collaborators include Christine L. Willis, Kate M. J. de Mattos-Shipley, Zhongshu Song, Matthew P. Crump, and Russell J. Cox.

Simpson has published multiple articles in several scientific journals and databases discussed as frequent venues for their research dissemination. These include:

  • The Cambridge Structural Database
  • Natural Product Reports
  • Angewandte Chemie International Edition
  • Chemical Science
  • Journal of Natural Products

In recognition of their scientific contributions, Thomas J. Simpson was awarded the title of Fellow of the Royal Society, United Kingdom, in 2001.

Best Publications

  • Meroterpenoids produced by fungi

    Regina Geris;Thomas J. Simpson

  • A chain initiation factor common to both modular and aromatic polyketide synthases

    Christian Bisang;Paul F. Long;Jesús Cortés;James Westcott

  • Characterization of the Mupirocin Biosynthesis Gene Cluster from Pseudomonas fluorescens NCIMB 10586

    A.Kassem El-Sayed;Joanne Hothersall;Sian M. Cooper;Elton Stephens

  • Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum

    Zhongshu Song;Russell J. Cox;Colin M. Lazarus;Thomas J. Simpson

  • Design and utility of oligonucleotide gene probes for fungal polyketide synthases

    Thomas P Nicholson;Brian A.M Rudd;Mike Dawson;Colin M Lazarus

  • Effect of gamma irradiation on the extraction yield, total phenolic content and free radical-scavenging activity of Nigella staiva seed.

    Khanzadi Fatima Khattak;Khanzadi Fatima Khattak;Thomas James Simpson;Ihasnullah

  • Ketosynthase Domain Probes Identify Two Subclasses of Fungal Polyketide Synthase Genes

    Lewis E.H Bingle;Thomas J Simpson;Colin M Lazarus

  • Resistance to and synthesis of the antibiotic mupirocin

    Christopher M. Thomas;Joanne Hothersall;Christine L. Willis;Thomas J. Simpson

  • An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.

    Ioannis Eleftherianos;Sam Boundy;Susan A. Joyce;Shazia Aslam

  • Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

    Matthew P. Crump;John Crosby;Christopher E. Dempsey;John A. Parkinson

  • Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis

    Jack Davison;Ahmed al Fahad;Menghao Cai;Zhongshu Song

  • Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana

    Kirstin L. Eley;Laura M. Halo;Zhongshu Song;Henry Powles

  • Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

    Laura M. Halo;James W. Marshall;Ahmed A. Yakasai;Zhongshu Song

  • Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana.

    Laura M Halo;Mary N Heneghan;Ahmed A Yakasai;Zhongshu Song

  • First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster

    Mary N. Heneghan;Ahmed A. Yakasai;Laura M. Halo;Zhongshu Song

  • Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.

    Katja M. Fisch;Walid Bakeer;Walid Bakeer;Ahmed A. Yakasai;Zhongshu Song

  • Ultraviolet-Irradiated Urocanic Acid Suppresses Delayed-Type Hypersensitivity to Herpes Simplex Virus in Mice

    James A Ross;Sarah E M Howie;Mary Norval;Jean Maingay

  • UROCANIC ACID AND IMMUNOSUPPRESSION

    M. Norval;T. J. Simpson;J. A. Ross

  • Plant Polyketide Synthases: A Chalcone Synthase-Type Enzyme Which Performs a Condensation Reaction with Methylmalonyl-CoA in the Biosynthesis of C-Methylated Chalcones†,‡

    Joachim Schröder;Sigrid Raiber;Thorsten Berger;Axel Schmidt

  • One pathway, many compounds: heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity

    Zahida Wasil;Khomaizon Abdul Kadir Pahirulzaman;Craig P Butts;Thomas J Simpson

  • Catalytic self-acylation of type II polyketide synthase acyl carrier proteins

    Timothy S. Hitchman;John Crosby;Kate J. Byrom;Russell J. Cox

Frequent Co-Authors

Russell J. Cox
Russell J. Cox University of Hannover
Christine L. Willis
Christine L. Willis University of Bristol
Matthew P. Crump
Matthew P. Crump University of Bristol
Christopher M. Thomas
Christopher M. Thomas University of Birmingham
Colin M. Lazarus
Colin M. Lazarus University of Bristol
John C. Vederas
John C. Vederas University of Alberta
Mary Norval
Mary Norval University of Edinburgh
Jake MacMillan
Jake MacMillan University of Bristol
Rob Lavigne
Rob Lavigne KU Leuven
David A. Hopwood
David A. Hopwood John Innes Centre

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