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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
18239
World Ranking
10046
National Ranking
4396

Overview

Jean E. Schaffer is affiliated with Harvard University in the United States and has made significant contributions to the fields of biochemistry, genetics, molecular biology, and medicine.

The scientist's main fields of study encompass:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of research include:

  • Molecular Biology
  • Physiology
  • Cancer Research
  • Cardiology and Cardiovascular Medicine
  • Biochemistry

The research topics covered in their publications are:

  • RNA modifications and cancer
  • Peroxisome Proliferator-Activated Receptors
  • Lysosomal Storage Disorders Research
  • Cancer-related molecular mechanisms research
  • Lipid metabolism and biosynthesis
  • RNA Research and Splicing
  • Sphingolipid Metabolism and Signaling

Recent published papers include:

  • "Circulating ceramide ratios and risk of vascular brain aging and dementia," 2020, Annals of Clinical and Translational Neurology
  • "Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment," 2020, Journal of Lipid Research
  • "Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis," 2021, Nature Communications
  • "Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations," 2020, Journal of Lipid and Atherosclerosis
  • "Application of N-palmitoyl-O-phosphocholineserine for diagnosis and assessment of response to treatment in Niemann-Pick type C disease," 2020, Molecular Genetics and Metabolism

Frequent publication venues for Jean E. Schaffer are:

  • Nature Communications
  • Journal of Lipid Research
  • Molecular Genetics and Metabolism
  • The FASEB Journal
  • Circulation

Notable frequent co-authors collaborating with this scientist include:

  • Xuntian Jiang
  • Daniel S. Ory
  • Linda R. Peterson
  • Rohini Sidhu
  • Sarah E. Gale

Best Publications

  • Triglyceride accumulation protects against fatty acid-induced lipotoxicity

    Laura L. Listenberger;Xianlin Han;Sarah E. Lewis;Sylvaine Cases

  • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein.

    Jean E. Schaffer;Harvey F. Lodish

  • A novel mouse model of lipotoxic cardiomyopathy.

    Hsiu-Chiang Chiu;Attila Kovacs;David A. Ford;Fong-Fu Hsu

  • Palmitate-induced apoptosis can occur through a ceramide-independent pathway.

    Laura L. Listenberger;Daniel S. Ory;Jean E. Schaffer

  • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

    Nica M. Borradaile;Xianlin Han;Jeffrey D. Harp;Sarah E. Gale

  • Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy

    Hsiu-Chiang Chiu;Attila Kovacs;Robert M. Blanton;Xianlin Han

  • Diet-Induced Obesity Model: Abnormal Oocytes and Persistent Growth Abnormalities in the Offspring

    Emily S. Jungheim;Erica L. Schoeller;Kerri L. Marquard;Erica D. Louden

  • Cholesterol Oxidation Products Are Sensitive and Specific Blood-Based Biomarkers for Niemann-Pick C1 Disease

    Forbes D. Porter;David E. Scherrer;Michael H. Lanier;S. Joshua Langmade

  • Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis.

    S K Weller;A Spadaro;J E Schaffer;A W Murray

  • As A Matter of Fat

    Rita T. Brookheart;Carlos I. Michel;Jean E. Schaffer

  • DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity.

    Li Liu;XiaoJing Shi;Kalyani G. Bharadwaj;Shota Ikeda

  • A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma

    Xuntian Jiang;Rohini Sidhu;Forbes D. Porter;Nicole M. Yanjanin

  • Modulation of Hormone-sensitive Lipase and Protein Kinase A-mediated Lipolysis by Perilipin A in an Adenoviral Reconstituted System

    Sandra C. Souza;Kizito V. Muliro;Laura Liscum;Ping Lien

  • Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.

    Kensuke Tsushima;Heiko Bugger;Adam R. Wende;Jamie Soto

  • NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

    Andrey Frolov;Sarah E. Zielinski;Jan R. Crowley;Nicole Dudley-Rucker

  • Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress

    Carlos I. Michel;Christopher L. Holley;Benjamin S. Scruggs;Rohini Sidhu

  • Fatty acid transport: the roads taken.

    Jean E. Schaffer

  • Niemann-Pick Type C1 I1061T Mutant Encodes a Functional Protein That Is Selected for Endoplasmic Reticulum-associated Degradation Due to Protein Misfolding *

    Mark E. Gelsthorpe;Nikola Baumann;Elizabeth Millard;Sarah E. Gale

  • Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane.

    Christina E. Gargiulo;Sarah M. Stuhlsatz-Krouper;Jean E. Schaffer

  • Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.

    Douglas G. Mashek;Karin E. Bornfeldt;Rosalind A. Coleman;Johannes Berger

Frequent Co-Authors

Daniel S. Ory
Daniel S. Ory Washington University in St. Louis
Forbes D. Porter
Forbes D. Porter National Institutes of Health
Ramachandran S. Vasan
Ramachandran S. Vasan The University of Texas Health Science Center at San Antonio
E. Dale Abel
E. Dale Abel University of California, Los Angeles
Elizabeth Berry-Kravis
Elizabeth Berry-Kravis Rush University Medical Center
Douglas F. Covey
Douglas F. Covey Washington University in St. Louis
Xianlin Han
Xianlin Han The University of Texas Health Science Center at San Antonio
Fong-Fu Hsu
Fong-Fu Hsu Washington University in St. Louis
Steven U. Walkley
Steven U. Walkley Albert Einstein College of Medicine
Sudha Seshadri
Sudha Seshadri The University of Texas Health Science Center at San Antonio

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