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Medicine

D-Index
80
Citations
19406
World Ranking
17282
National Ranking
8659

Overview

Darren J. Kelly is affiliated with Ascension Health in the United States and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research encompasses 44 publications in medicine and 21 in biochemistry and related molecular sciences, with a strong focus on both fundamental and applied biomedical topics.

Their work spans several subfields including molecular biology, cardiology and cardiovascular medicine, physiology, cancer research, and rheumatology. These diverse subfields underscore a broad interdisciplinary approach to understanding complex biological systems and disease mechanisms.

Kelly's investigations concentrate on a range of topics, prominently featuring cardiovascular function and risk factors, nitric oxide and endothelin effects, circular RNAs and microRNAs related to disease regulation, cardiac fibrosis and remodeling, heart failure treatment and management, as well as hormonal regulation and hypertension.

Among their recent published papers are:

  • Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers, 2021, Science Translational Medicine
  • Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature, 2020, British Journal of Pharmacology
  • International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology, 2023, Kidney International
  • Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings, 2022, Toxins
  • Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome, 2020, International Journal of Cardiology

Their frequent co-authors include Andrew R. Kompa, Amanda J. Edgley, Feby Savira, Bing H. Wang, and Beat M. Jucker. These collaborations have supported research outputs primarily published in venues such as the International Journal of Cardiology, Life Sciences, Journal of Small Animal Practice, bioRxiv, and Science Translational Medicine. Kelly has published four papers in the International Journal of Cardiology alone.

The scientist's work reflects a strong orientation towards translational and clinical research, particularly addressing cardiovascular and renal conditions. The repeated focus on cardiorenal syndrome and endothelial dysfunction highlights a specialized interest in multi-organ interrelations and the molecular underpinnings of disease progression.

Best Publications

  • Intensity of renal support in critically ill patients with acute kidney injury

    Paul M. Palevsky;Jane Hongyuan Zhang;Theresa Z. O'Connor;Glenn M. Chertow

  • Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.

    Mark E. Cooper;Dimitria Vranes;Sherif Youssef;Steven A. Stacker

  • Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation

    Hany S Abed;Chrishan Surendran Samuel;Dennis H Lau;Darren James Kelly

  • Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

    Suree Lekawanvijit;Anastasia Adrahtas;Darren J. Kelly;Andrew R. Kompa;Andrew R. Kompa

  • Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition.

    Robyn G Langham;Darren J Kelly;Alison J Cox;Napier M Thomson

  • Direct Actions of Urotensin II on the Heart: Implications for Cardiac Fibrosis and Hypertrophy

    Alex Tzanidis;Ross D Hannan;Walter G Thomas;Done Onan

  • The (Pro)Renin Receptor: Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney

    Andrew Advani;Darren J. Kelly;Alison J. Cox;Kathryn E. White

  • Retinal Neovascularization Is Prevented by Blockade of the Renin-Angiotensin System

    Christina J. Moravski;Darren J. Kelly;Mark E. Cooper;Richard E. Gilbert

  • Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.

    Darren James Kelly;Yuan Zhang;Claire Hepper;Renae Martine Gow

  • Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases.

    S. V. McLennan;D. J. Kelly;A. J. Cox;Z. Cao

  • Vascular endothelial growth factor and its receptors in control and diabetic rat eyes

    Richard E. Gilbert;Dimitria Vranes;Jennifer L. Berka;Darren J. Kelly

  • Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model

    Dennis H. Lau;Lorraine Mackenzie;Darren J. Kelly;Peter J. Psaltis

  • Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats

    D. J. Kelly;Y. Zhang;G. Moe;G. Naik

  • Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes

    R. E. Gilbert;D. J. Kelly;A. J. Cox;J. L. Wilkinson-Berka

  • Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis.

    Georgina Paizis;Richard E Gilbert;Mark E Cooper;Padma Murthi

  • Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade.

    S A Mifsud;T J Allen;John F Bertram;U L Hulthen

  • A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

    Darren J. Kelly;Jennifer L. Wilkinson-Berka;Terri J. Allen;Mark E. Cooper

  • Cardiorenal Syndrome The Emerging Role of Protein-Bound Uremic Toxins

    Suree Lekawanvijit;Andrew Richard Kompa;Bing Hui Wang;Darren J Kelly

  • Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis.

    Zemin Cao;Darren J. Kelly;Alison Cox;David Casley

  • Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

    Andrew Advani;Qingling Huang;Kerri Thai;Suzanne L. Advani

Frequent Co-Authors

Richard E. Gilbert
Richard E. Gilbert St. Michael's Hospital
Henry Krum
Henry Krum Monash University
Mark E. Cooper
Mark E. Cooper Monash University
Carol A. Pollock
Carol A. Pollock University of Sydney
Prashanthan Sanders
Prashanthan Sanders University of Adelaide
Spencer J. Williams
Spencer J. Williams University of Melbourne
George Jerums
George Jerums University of Melbourne
Christopher M. Reid
Christopher M. Reid Monash University
Alicia J. Jenkins
Alicia J. Jenkins University of Sydney
Jennifer H. Martin
Jennifer H. Martin University of Newcastle Australia

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