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Molecular Biology

D-Index
61
Citations
18493
World Ranking
1882
National Ranking
937

Overview

Richard Koche is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focuses on areas within biochemistry, genetics, and molecular biology, contributing across 264 publications. Medicine is another significant field, with 199 publications attributed to their work.

The scientist's subfields of study include molecular biology, hematology, oncology, genetics, and cancer research. These subfields represent a range of expertise, with molecular biology accounting for 207 publications and substantial involvement in hematology (52), oncology (50), genetics (47), and cancer research (32).

Key topics covered by Koche's research are epigenetics and DNA methylation, acute myeloid leukemia research, cancer genomics and diagnostics, myeloproliferative neoplasms related to diagnosis and treatment, chromatin remodeling and cancer, protein degradation and inhibitors, and genomics and chromatin dynamics. The counts of publications in these areas reflect a broad and detailed engagement with cancer biology and molecular mechanisms.

Frequent collaborators provide insight into the breadth of Koche's research network. Notable coauthors include Yingqian A. Zhan, Ross L. Levine, Elisa de Stanchina, Raajit K. Rampal, and Charles M. Rudin. These partnerships are sustained over multiple publications, indicating ongoing collaborative research efforts.

Koche has published extensively in several venues, with a considerable number of works in bioRxiv (Cold Spring Harbor Laboratory), Blood, Cancer Research, Cancer Discovery, and Nature. These venues highlight Koche's active presence in high-impact and specialized journals relevant to cancer and molecular biology research.

Recent publications illustrate the scope and focus of their recent scientific inquiries:

  • A gene-environment-induced epigenetic program initiates tumorigenesis, 2021, Nature
  • L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer, 2020, Nature Cancer
  • ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer, 2020, Nature Genetics
  • Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma, 2020, Nature Communications
  • An epigenetic barrier sets the timing of human neuronal maturation, 2024, Nature

Best Publications

  • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

    Tarjei S. Mikkelsen;Manching Ku;Manching Ku;David B. Jaffe;Biju Issac;Biju Issac

  • Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

    Manching Ku;Richard P. Koche;Richard P. Koche;Richard P. Koche;Esther Rheinbay;Esther Rheinbay;Esther Rheinbay;Eric M. Mendenhall;Eric M. Mendenhall

  • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.

    Omar Abdel-Wahab;Mazhar Adli;Lindsay M. LaFave;Jie Gao

  • GC-rich sequence elements recruit PRC2 in mammalian ES cells

    Thanh Truong;Biju Issac;Eric M Mendenhall;Richard Patrick Koche

  • GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

    Eric M Mendenhall;Richard Patrick Koche;Thanh Truong;Thanh Truong;Thanh Truong;Vicky Weijie Zhou

  • Reprogramming factor expression initiates widespread targeted chromatin remodeling.

    Richard P. Koche;Zachary D. Smith;Zachary D. Smith;Mazhar Adli;Mazhar Adli;Hongcang Gu

  • Loss of BAP1 function leads to EZH2-dependent transformation.

    Lindsay M. Lafave;Wendy Béguelin;Richard Koche;Matt Teater

  • Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

    Omar Abdel-Wahab;Jie Gao;Mazhar Adli;Anwesha Dey

  • The MicrobesOnline Web site for comparative genomics

    Eric J. Alm;Katherine H. Huang;Morgan N. Price;Richard P. Koche

  • Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

    Richard P. Koche;Elias Rodriguez-Fos;Konstantin Helmsauer;Martin Burkert;Martin Burkert

  • Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

    Maria Kleppe;Richard Koche;Lihua Zou;Peter van Galen

  • DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

    Olga A Guryanova;Kaitlyn Shank;Barbara Spitzer;Luisa Luciani

  • Targeting chromatin regulators inhibits leukemogenic gene expression in npm1 mutant leukemia

    Scott A. Armstrong

  • α-Ketoglutarate links p53 to cell fate during tumour suppression

    John P. Morris;Jossie J. Yashinskie;Jossie J. Yashinskie;Richard Koche;Rohit Chandwani

  • DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL -rearranged leukemia

    Chun-Wei Chen;Richard P Koche;Amit U Sinha;Aniruddha J Deshpande

  • A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription

    Shu-Ping Wang;Zhanyun Tang;Chun-Wei Chen;Miho Shimada

  • A gene–environment-induced epigenetic program initiates tumorigenesis

    Direna Alonso-Curbelo;Yu-Jui Ho;Cassandra Burdziak;Cassandra Burdziak;Jesper L. V. Maag

  • H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

    Manching Ku;Jacob D. Jaffe;Richard Patrick Koche;Esther Rheinbay

  • L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer

    Karuna Ganesh;Harihar Basnet;Yasemin Kaygusuz;Ashley M. Laughney;Ashley M. Laughney

  • AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

    Aniruddha J. Deshpande;Anagha Deshpande;Amit U. Sinha;Liying Chen

Frequent Co-Authors

Scott A. Armstrong
Scott A. Armstrong Harvard University
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
David Torrents
David Torrents Barcelona Supercomputing Center
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Martin S. Tallman
Martin S. Tallman Northwestern University
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School
Nicholas D. Socci
Nicholas D. Socci Memorial Sloan Kettering Cancer Center
Christopher E. Mason
Christopher E. Mason Cornell University

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