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Biology and Biochemistry

D-Index
54
Citations
19996
World Ranking
15355
National Ranking
1209

Overview

Robert J Klose is affiliated with the University of Oxford in the United Kingdom and specializes primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their research work encompasses several subfields, including Molecular Biology, Plant Science, Cancer Research, Genetics, and Immunology.

Their research focuses on key topics such as:

  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Chromosomal and Genetic Variations
  • Pluripotent Stem Cells Research
  • Advanced biosensing and bioanalysis techniques

Robert J Klose has published extensively in a range of scientific venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Cell
  • Nature Structural & Molecular Biology
  • Cell

Some of their recent papers include:

  • The molecular principles of gene regulation by Polycomb repressive complexes, 2021, Nature Reviews Molecular Cell Biology
  • Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells, 2020, Cell Reports
  • Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation, 2020, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency, 2021, Nature Structural & Molecular Biology
  • Recycling of modified H2A-H2B provides short-term memory of chromatin states, 2023, Cell

They frequently collaborate with other researchers, including Neil P. Blackledge, Emilia Dimitrova, Aleksander Szczurek, Miles K. Huseyin, and Jessica R. Kelley.

Best Publications

  • Genomic DNA methylation: the mark and its mediators.

    Robert J. Klose;Adrian P. Bird

  • JmjC-domain-containing proteins and histone demethylation.

    Robert J. Klose;Eric M. Kallin;Yi Zhang

  • The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

    Rasheduzzaman Chowdhury;Kar Kheng Yeoh;Ya-Min Tian;Lars Hillringhaus

  • Regulation of histone methylation by demethylimination and demethylation.

    Robert J. Klose;Yi Zhang

  • The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

    Robert J. Klose;Kenichi Yamane;Kenichi Yamane;Yangjin Bae;Dianzheng Zhang

  • Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

    Neil P. Blackledge;Anca M. Farcas;Takashi Kondo;Hamish W. King

  • Understanding the relationship between DNA methylation and histone lysine methylation.

    Nathan R. Rose;Robert J. Klose

  • PLU-1 Is an H3K4 Demethylase Involved in Transcriptional Repression and Breast Cancer Cell Proliferation

    Kenichi Yamane;Keisuke Tateishi;Robert J. Klose;Jia Fang

  • The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

    Robert J. Klose;Qin Yan;Qin Yan;Zuzana Tothova;Zuzana Tothova;Kenichi Yamane

  • KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas;Neil P Blackledge;Ian Sudbery;Hannah K Long;Hannah K Long

  • DNA Binding Selectivity of MeCP2 Due to a Requirement for A/T Sequences Adjacent to Methyl-CpG

    Robert J. Klose;Shireen A. Sarraf;Lars Schmiedeberg;Suzanne M. McDermott

  • Targeting Polycomb systems to regulate gene expression: modifications to a complex story

    Neil P. Blackledge;Nathan R. Rose;Robert J. Klose

  • Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

    David Landeira;Stephan P A Sauer;Raymond Poot;Maria Dvorkina

  • Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.

    Sarah Cooper;Martin Dienstbier;Raihann Hassan;Lothar Schermelleh

  • CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

    Neil P. Blackledge;Jin C. Zhou;Michael Y. Tolstorukov;Anca M. Farcas

  • MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

    Kok Lian Ho;Iain W. McNae;Lars Schmiedeberg;Robert J. Klose

  • The molecular principles of gene regulation by Polycomb repressive complexes.

    Neil P. Blackledge;Robert J. Klose

  • Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

    Jifang Tao;Keping Hu;Keping Hu;Keping Hu;Qiang Chang;Qiang Chang;Hao Wu

  • ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

    Hannah K. Long;Hannah K. Long;Neil P. Blackledge;Robert J. Klose

  • Dynamic protein methylation in chromatin biology

    S S Ng;W W Yue;U Oppermann;R J Klose

Frequent Co-Authors

Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Yi Zhang
Yi Zhang Harvard University
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Neil Brockdorff
Neil Brockdorff University of Oxford
Udo Oppermann
Udo Oppermann University of Oxford
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University
Duncan T. Odom
Duncan T. Odom University of Cambridge
Paul Tempst
Paul Tempst Memorial Sloan Kettering Cancer Center
Adrian Bird
Adrian Bird University of Edinburgh

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