World's Best Scientists 2026 revealed!
Jean-Charles Schwartz

Jean-Charles Schwartz

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Biology and Biochemistry
France
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
125
Citations
46845
World Ranking
514
National Ranking
9

Medicine

D-Index
126
Citations
47711
World Ranking
2994
National Ranking
76

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in France Leader Award
  • 2025 - Research.com Biology and Biochemistry in France Leader Award

Overview

Jean-Charles Schwartz is affiliated with Bioprojet in France and has a research focus centered on neuroscience, particularly within the domains of sleep and wakefulness. Their work spans several subfields including cognitive neuroscience, endocrine and autonomic systems, sensory systems, immunology, and physiology.

The scientist's research contributions have been published in various journals with repeat appearances in prominent venues such as the IUPHAR/BPS Guide to Pharmacology CITE and SLEEP. Other notable publication venues include CNS Drugs, British Journal of Clinical Pharmacology, and the American Journal of Respiratory and Critical Care Medicine.

Key research topics in Schwartz's work include:

  • Sleep and Wakefulness Research
  • Olfactory and Sensory Function Studies
  • Mast cells and histamine
  • Obstructive Sleep Apnea Research
  • Neuroscience of respiration and sleep
  • Circadian rhythm and melatonin
  • Sleep and related disorders

Frequent collaborators of Jean-Charles Schwartz include Jeanne-Marie Lecomte, Jeffrey M. Dayno, Donna Zarycranski, Yves Dauvilliers, and Craig W. Davis, with multiple joint publications contributing to the field.

Recent papers by Schwartz and their coauthors highlight topics related to sleep disorders and pharmacology of wake-promoting agents. Selected recent publications include:

  • "Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial" (2020), published in American Journal of Respiratory and Critical Care Medicine
  • "Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP" (2020), published in CHEST Journal
  • "Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET" (2020), published in British Journal of Pharmacology
  • "Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol" (2021), published in Pharmacology Research & Perspectives
  • "Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials" (2021), published in CNS Drugs

Best Publications

  • Formation and inactivation of endogenous cannabinoid anandamide in central neurons.

    V. Di Marzo;A. Fontana;H. Cadas;S. Schinelli

  • High-affinity enkephalin-degrading peptidase in brain is increased after morphine

    B. Malfroy;J. P. Swerts;A. Guyon;B. P. Roques

  • Alternative splicing directs the expression of two D2 dopamine receptor isoforms

    Bruno Giros;Pierre Sokoloff;Marie-Pascale Martres;Jean-François Riou

  • BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization.

    Olivier Guillin;Jorge Diaz;Patrick Carroll;Nathalie Griffon

  • Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist.

    Maria Pilla;Sylvie Perachon;Sylvie Perachon;FranÇois Sautel;Fabrice Garrido

  • Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase.

    Jean-Charles Schwartz;Bernard Malfroy;Sophie De La Baume

  • A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation.

    M. Ruat;E. Traiffort;J.M. Arrang;J. Tardivellacombe

  • A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with [125I]iodosulpride.

    M.-L. Bouthenet;M.-P. Martres;N. Sales;J.-C. Schwartz

  • Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.

    Pierre Sokoloff;Marc Andrieux;Roger Besançon;Catherine Pilon

  • A detailed mapping of the histamine H3 receptor and its gene transcripts in rat brain

    C Pillot;Anne Héron;V Cochois;J Tardivel-Lacombe

  • Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain

    J. Diaz;D. Lévesque;C.H. Lammers;N. Griffon

  • Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.

    Régis Bordet;Sophie Ridray;Suzanna Carboni;Jorge Diaz

  • Histamine as a neurotransmitter in mammalian brain: neurochemical evidence.

    Jean-Charles Schwartz;Hélène Pollard;Thanh Tarn Quach

  • Dopamine D3 Receptors Expressed by All Mesencephalic Dopamine Neurons

    Jorge Diaz;Catherine Pilon;Bernard Le Foll;Claude Gros

  • Novel dopamine receptors half a decade later.

    Pierre Sokoloff;Jean-Charles Schwartz

  • A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas

    H. Pollard;J. Moreau;J.M. Arrang;J.C. Schwartz

  • Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

    M A Crocq;R Mant;P Asherson;Julie Williams

  • Pitolisant versus placebo or modafinil in patients with narcolepsy : a double-blind, randomised trial

    Yves Dauvilliers;Claudio Bassetti;Gert Jan Lammers;Isabelle Arnulf

  • Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors.

    J M Arrang;M Garbarg;J C Schwartz

  • Enkephalin receptors on dopaminergic neurones in rat striatum.

    H. Pollard;C. Llorens-Cortes;J. C. Schwartz

Frequent Co-Authors

Pierre Sokoloff
Pierre Sokoloff Grenoble Alpes University
Walter Schunack
Walter Schunack Freie Universität Berlin
Holger Stark
Holger Stark Max Planck Society
Yves Dauvilliers
Yves Dauvilliers University of Montpellier
Bruno Giros
Bruno Giros McGill University
Elisabeth Traiffort
Elisabeth Traiffort Inserm : Institut national de la santé et de la recherche médicale
Michel Baudry
Michel Baudry Western University of Health Sciences
Isabelle Arnulf
Isabelle Arnulf Sorbonne University
Philip Gorwood
Philip Gorwood Université Paris Cité
Josué Feingold
Josué Feingold Grenoble Alpes University

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