World's Best Scientists 2026 revealed!
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Computer Science
Germany
2025

D-Index & Metrics

Computer Science

D-Index
82
Citations
40445
World Ranking
934
National Ranking
32

Biology and Biochemistry

D-Index
94
Citations
50026
World Ranking
1960
National Ranking
134

Research.com Recognitions

  • 2025 - Research.com Computer Science in Germany Leader Award
  • 2022 - Research.com Computer Science in Germany Leader Award
  • 2015 - Fellow of the International Society for Computational Biology
  • 2010 - Member of Academia Europaea
  • 2003 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Informatics

Overview

Thomas Lengauer is affiliated with the Max Planck Institute for Informatics in Germany. Their research spans multiple areas within medicine and the life sciences, with a particular focus on computational applications across these domains.

Their main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader fields, their work touches on several subfields, such as Molecular Biology, Infectious Diseases, Epidemiology, Virology, and Genetics.

Research topics commonly addressed by Lengauer include HIV/AIDS drug development and treatment, HIV research and treatment, epigenetics and DNA methylation, RNA modifications and cancer, HIV/AIDS research and interventions, hepatitis C virus research, and genetic syndromes and imprinting.

The scientist has contributed to a number of recent papers, showcasing a range of focus areas and collaboration with various coauthors. Notable recent publications include:

  • Quantitative comparison of within-sample heterogeneity scores for DNA methylation data, 2020, Nucleic Acids Research
  • Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz, 2020, Nature Protocols
  • Rhinovirus prevalence as indicator for efficacy of measures against SARS-CoV-2, 2021, BMC Public Health
  • Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe, 2022, BMC Public Health
  • Cohort Profile: A European Multidisciplinary Network for the Fight against HIV Drug Resistance (EuResist Network), 2023, Tropical Medicine and Infectious Disease

Frequent collaborators include Rolf Kaiser, Martin Pirkl, Michael Scherer, Jörn Walter, and Gibran Horemheb-Rubio.

Lengauer has published in several journals and venues often, with the most frequent being Bioinformatics Advances, BMC Public Health, Journal of Medical Virology, bioRxiv (Cold Spring Harbor Laboratory), and Nucleic Acids Research.

Among their book publications is "Computational Advances in Bio and Medical Sciences," published by Springer Science+Business Media in 2021.

Recognized by several institutions, Lengauer has received the following awards:

  • Fellow of the International Society for Computational Biology (2015)
  • Member of Academia Europaea (2010)
  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften for Informatics (2003)

Best Publications

  • ROCR: visualizing classifier performance in R

    Tobias Sing;Oliver Sander;Niko Beerenwinkel;Thomas Lengauer

  • A Fast Flexible Docking Method using an Incremental Construction Algorithm

    Matthias Rarey;Bernd Kramer;Thomas Lengauer;Gerhard Klebe

  • Permutation importance

    André Altmann;Laura Toloşi;Oliver Sander;Thomas Lengauer

  • Improved scoring of functional groups from gene expression data by decorrelating GO graph structure

    Adrian Alexa;Jörg Rahnenführer;Thomas Lengauer

  • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

    Jochen Hampe;Andre Franke;Philip Rosenstiel;Philip Rosenstiel;Andreas Till

  • Computing topological parameters of biological networks

    Yassen Assenov;Fidel Ramírez;Sven-Eric Schelhorn;Thomas Lengauer

  • Combinatorial Algorithms for Integrated Circuit Layout

    Thomas Lengauer

  • Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking.

    Bernd Kramer;Matthias Rarey;Thomas Lengauer

  • Computational methods for biomolecular docking

    Thomas Lengauer;Matthias Rarey

  • A fast algorithm for finding dominators in a flowgraph

    Thomas Lengauer;Robert Endre Tarjan

  • A new measure for functional similarity of gene products based on Gene Ontology.

    Andreas Schlicker;Francisco S Domingues;Jörg Rahnenführer;Thomas Lengauer

  • BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing

    Christoph Bock;Sabine Reither;Thomas Mikeska;Martina Paulsen

  • Comprehensive analysis of DNA methylation data with RnBeads

    Yassen Assenov;Fabian Müller;Pavlo Lutsik;Jörn Walter

  • Engineering support vector machine kernels that recognize translation initiation sites

    Alexander Zien;Gunnar Rätsch;Sebastian Mika;Bernhard Schölkopf

  • FlexE: efficient molecular docking considering protein structure variations.

    H Claussen;C Buning;M Rarey;T Lengauer

  • Genetic variation in DLG5 is associated with inflammatory bowel disease

    Monika Stoll;Brit Corneliussen;Christine M Costello;Georg H Waetzig

  • Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

    Simon Reiss;Ilka Rebhan;Perdita Backes;Ines Romero-Brey

  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Hendrik G. Stunnenberg;Martin Hirst

  • Sarcoidosis is associated with a truncating splice site mutation in BTNL2.

    Ruta Valentonyte;Jochen Hampe;Klaus Huse;Philip Rosenstiel

  • Classification with correlated features

    Laura Toloşi;Thomas Lengauer

  • Genomic distribution and inter-sample variation of non-CpG methylation across human cell types.

    Michael J. Ziller;Fabian Müller;Jing Liao;Jing Liao;Yingying Zhang;Yingying Zhang

  • Engineering Support Vector Machine Kerneis That Recognize Translation Initialion Sites.

    Alexander Zien;Gunnar Rätsch;Sebastian Mika;Bernhard Schölkopf

Frequent Co-Authors

Rolf Kaiser
Rolf Kaiser University of Cologne
Mario Albrecht
Mario Albrecht Max Planck Society
Christoph Bock
Christoph Bock Austrian Academy of Sciences
Jörn Walter
Jörn Walter Saarland University
Philip Rosenstiel
Philip Rosenstiel Kiel University
Joachim Selbig
Joachim Selbig Max Planck Society
Matthias Rarey
Matthias Rarey Universität Hamburg
Maurizio Zazzi
Maurizio Zazzi University of Siena
Benedikt Brors
Benedikt Brors German Cancer Research Center

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