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Matthijs K. C. Hesselink

Matthijs K. C. Hesselink

D-Index & Metrics

Medicine

D-Index
84
Citations
21207
World Ranking
15290
National Ranking
584

Overview

Matthijs K. C. Hesselink is affiliated with Maastricht University in the Netherlands and has contributed extensively to the fields of medicine, biochemistry, genetics, and molecular biology. Their research spans several subfields, notably physiology, molecular biology, cell biology, biochemistry, and endocrine and autonomic systems. The primary focus of their scientific work involves various aspects of metabolism and molecular mechanisms related to metabolic health.

Their main research topics include:

  • Adipose Tissue and Metabolism
  • Diet and metabolism studies
  • Muscle metabolism and nutrition
  • Mitochondrial Function and Pathology
  • Lipid metabolism and biosynthesis
  • Circadian rhythm and melatonin
  • Metabolism and Genetic Disorders

Matthijs K. C. Hesselink has published numerous papers, some of the notable recent works being:

  • Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans, 2020, Physiological Reports
  • Timing of physical activity in relation to liver fat content and insulin resistance, 2022, Diabetologia
  • A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes, 2022, Nature Communications
  • Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity, 2020, Diabetologia
  • Resveratrol supplementation reduces ACE2 expression in human adipose tissue, 2021, Adipocyte

Their frequent co-authors include Patrick Schrauwen, Joris Hoeks, Vera B. Schrauwen-Hinderling, Gert Schaart, and Anne Gemmink, with whom they have collaborated on multiple research projects.

Matthijs K. C. Hesselink's work is regularly published in scientific journals such as Diabetologia, Physiological Reports, Nature Communications, Molecular Metabolism, and Obesity.

Best Publications

  • Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

    Silvie Timmers;Ellen Konings;Lena Bilet;Riekelt H. Houtkooper

  • ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

    Guenter Haemmerle;Tarek Moustafa;Gerald Woelkart;Sabrina Büttner

  • Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

    Mark J W Hanssen;Joris Hoeks;Boudewijn Brans;Anouk A J J van der Lans

  • A new approach for the determination of ventilatory and lactate thresholds.

    B. Cheng;H. Kuipers;A. C. Snyder;H. A. Keizer

  • Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids

    René Koopman;Gert Schaart;Matthijs K. Hesselink

  • Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

    Patrick Schrauwen;Matthijs K.C. Hesselink

  • Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy.

    Estelle Woldt;Yasmine Sebti;Laura A Solt;Christian Duhem

  • Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

    Ruth C.R. Meex;Vera B. Schrauwen-Hinderling;Esther Moonen-Kornips;Gert Schaart

  • Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

    Esther Phielix;Vera B. Schrauwen-Hinderling;Marco Mensink;Ellen Lenaers

  • Intramyocellular lipid content in human skeletal muscle

    Vera B. Schrauwen-Hinderling;Matthijs K.C. Hesselink;Patrick Schrauwen;Marianne Eline Kooi

  • Physiological changes in male competitive cyclists after two weeks of intensified training.

    A. E. Jeukendrup;M. K. C. Hesselink;A. C. Snyder;H. Kuipers

  • Decreased Uncoupling Protein Expression and Intramyocytic Triglyceride Depletion in Formerly Obese Subjects

    Geltrude Mingrone;Giuseppina Rosa;Aldo V. Greco;Melania Manco

  • UCP2 and UCP3 in muscle controlling body metabolism.

    Patrick Schrauwen;Matthijs Hesselink

  • Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

    Matthijs K. C. Hesselink;Vera Schrauwen-Hinderling;Patrick Schrauwen

  • Mitochondrial dysfunction and lipotoxicity.

    Patrick Schrauwen;Vera Schrauwen-Hinderling;Joris Hoeks;Matthijs K.C. Hesselink

  • An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix

    Patrick Schrauwen;Wim H. M. Saris;Matthijs K C. Hesselink

  • Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

    Sander Kersten;Laeticia Lichtenstein;Emma Steenbergen;Karin Mudde

  • Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise

    Aaron P. Russell;Matthijs K. C. Hesselink;Sing Kai Lo;Patrick Schrauwen

  • Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1alpha and PPARbeta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus

    M. Mensink;M.K. Hesselink;A.P. Russell;G. Schaart

  • Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake.

    K. De Bock;W. Derave;B. O. Eijnde;M. K. Hesselink

Frequent Co-Authors

Patrick Schrauwen
Patrick Schrauwen Maastricht University
Sander Kersten
Sander Kersten Wageningen University & Research
Wim H. M. Saris
Wim H. M. Saris Maastricht University
Jan F. C. Glatz
Jan F. C. Glatz Maastricht University
Bart Staels
Bart Staels University of Lille
Ellen E. Blaak
Ellen E. Blaak Maastricht University
Anton J. M. Wagenmakers
Anton J. M. Wagenmakers Liverpool John Moores University
Hildo J. Lamb
Hildo J. Lamb Leiden University Medical Center
Michael Roden
Michael Roden Heinrich Heine University Düsseldorf
Asker E. Jeukendrup
Asker E. Jeukendrup Loughborough University

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