World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
67
Citations
17546
World Ranking
6842
National Ranking
2049

Biology and Biochemistry

D-Index
68
Citations
17784
World Ranking
7741
National Ranking
3528

Overview

David Cowburn is affiliated with the Albert Einstein College of Medicine in the United States. Their research is primarily situated within the broad field of Biochemistry, Genetics, and Molecular Biology, with a specific focus on Molecular Biology.

Their work encompasses several subfields, including Molecular Biology, Public Health, Environmental and Occupational Health, Infectious Diseases, Cell Biology, and Virology.

Key topics that feature prominently in their publications are:

  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • Nuclear Structure and Function
  • RNA regulation and disease
  • Mosquito-borne diseases and control
  • Viral Infections and Vectors
  • Genomics and Chromatin Dynamics

David Cowburn has contributed to a number of scientific papers, including:

  • "Improving the hole picture: towards a consensus on the mechanism of nuclear transport," 2023, Biochemical Society Transactions
  • "INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication," 2021, Nature Communications
  • "Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo," 2022, Cell chemical biology
  • "A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice," 2022, PLoS Pathogens
  • "Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport," 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), Biochemical Society Transactions, Nature Communications, Cell chemical biology, and PLoS Pathogens.

The scientist has worked alongside several frequent co-authors, notably Sean M. Cahill, Michael P. Rout, Samuel Sparks, Ryo Hayama, and Richard Harris.

Best Publications

  • Accurate quantitation of protein expression and site-specific phosphorylation

    Y. Oda;K. Huang;F. R. Cross;D. Cowburn

  • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.

    Ke Shuai;Curt M. Horvath;Linda H.Tsai Huang;Sajjad A. Qureshi

  • Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

    Gabriel Waksman;Steven E. Shoelson;Nalin Pant;David Cowburn

  • CRYSTAL-STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES

    Gabriel Waksman;Dorothea Kominos;Scott C. Robertson;Scott C. Robertson;Nalin Pant

  • Modular peptide recognition domains in eukaryotic signaling.

    John Kuriyan;David Cowburn

  • Solution Structure of the Proapoptotic Molecule BID: A Structural Basis for Apoptotic Agonists and Antagonists

    James M. McDonnell;David Fushman;Curt L. Milliman;Stanley J. Korsmeyer

  • Perspectives on NMR in drug discovery: a technique comes of age

    Maurizio Pellecchia;Ivano Bertini;David Cowburn;Claudio Dalvit

  • A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

    Chi Hon Lee;Benjamin Leung;Mark A. Lemmon;Jie Zheng

  • Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

    Xiaodong Wu;Beatrice Knudsen;Stephan M Feller;Jie Zheng

  • Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

    Jie Zheng;Sean M. Cahill;Mark A. Lemmon;David Fushman

  • Chemical ligation of folded recombinant proteins: Segmental isotopic labeling of domains for NMR studies

    Rong Xu;Brenda Ayers;David Cowburn;Tom W. Muir

  • LONG RANGE HYDROGEN BOND MEDIATED EFFECTS IN PEPTIDES: NITROGEN-15 NMR STUDY OF GRAMICIDIN S IN WATER AND ORGANIC SOLVENTS

    David H. Live;Donald G. Davis;William C. Agosta;David Cowburn

  • The main-chain dynamics of the dynamin pleckstrin homology (PH) domain in solution: analysis of 15N relaxation with monomer/dimer equilibration

    David Fushman;Sean Cahill;David Cowburn

  • A cell-penetrating helical peptide as a potential HIV-1 inhibitor.

    Hongtao Zhang;Qian Zhao;Shibani Bhattacharya;Abdul A. Waheed

  • Three-dimensional solution structure of the src homology 2 domain of c-abl.

    Michael Overduin;Carlos B. Rios;Bruce J. Mayer;David Baltimore

  • Direct Measurement of 15N Chemical Shift Anisotropy in Solution

    David Fushman;Nico Tjandra;David Cowburn

  • Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein–intein junction

    Alessandra Romanelli;Alexander Shekhtman;David Cowburn;Tom W. Muir

  • Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR)

    David S Burz;Kaushik Dutta;David Cowburn;Alexander Shekhtman

  • The affinity-labeling of partially purified acetylcholine receptor from electric tissue of Electrophorus.

    Arthur Karlin;David Cowburn

  • A novel, specific interaction involving the Csk SH3 domain and its natural ligand.

    Ranajeet Ghose;Alexander Shekhtman;Michael J. Goger;Hong Ji

  • Book Review: Nuclear magnetic resonance and its applications to living systems. David G. Gadian. Oxford Univ. Press, New York/Oxford, 1982. 197 pages. $29.95

    David Cowburn

Frequent Co-Authors

David Fushman
David Fushman University of Maryland, College Park
Jie Zheng
Jie Zheng University of California, Los Angeles
Tom W. Muir
Tom W. Muir Princeton University
Michael P. Rout
Michael P. Rout Rockefeller University
John Kuriyan
John Kuriyan Vanderbilt University
Amit Singer
Amit Singer Princeton University
George Barany
George Barany University of Minnesota
Michael Overduin
Michael Overduin University of Alberta
Jason A. Koutcher
Jason A. Koutcher Memorial Sloan Kettering Cancer Center
Arthur Karlin
Arthur Karlin Columbia University

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