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Medicine

D-Index
73
Citations
21772
World Ranking
19610
National Ranking
9764

Overview

Jason A. Koutcher is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research spans multiple intersecting fields including molecular biology, cancer research, biophysics, immunology, and oncology.

The scientist's recent publications cover a range of topics predominantly centered on cancer biology and imaging techniques. Notable papers include:

  • CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours (2021, Nature)
  • Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer's disease mouse model (2020, Scientific Reports)
  • Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy (2020, Molecular Therapy - Oncolytics)
  • Distinguishing metastatic triple-negative breast cancer from nonmetastatic breast cancer using second harmonic generation imaging and resonance Raman spectroscopy (2020, Journal of Biophotonics)
  • Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma (2023, Neuro-Oncology)

They collaborate frequently with a consistent group of co-authors, including Joseph A. Helpern, EX Wu, T Bathen, Zaver M. Bhujwalla, and Lavinia Spain, each contributing to 26 co-authored works.

The author's work is typically published in venues with a focus on biomedical imaging and cancer research. The frequent publication venues include:

  • NMR in Biomedicine
  • Cancer Research
  • Scientific Reports
  • Nature
  • Neuro-Oncology

Jason A. Koutcher's research fields and subfields highlight an integration of basic and applied biomedical sciences. Their key areas of study include:

  • Molecular Biology
  • Cancer Research
  • Biophysics
  • Immunology
  • Oncology

Within these domains, the scientist focuses especially on topics related to cancer biology and immune responses, including:

  • Cancer, Hypoxia, and Metabolism
  • Cancer Immunotherapy and Biomarkers
  • Metabolism, Diabetes, and Cancer
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Immune cells in cancer
  • Spectroscopy and Chemometric Analyses
  • Advanced Fluorescence Microscopy Techniques

The combined focus on metabolic pathways, immune cell dynamics, and advanced imaging modalities provides a multifaceted approach to understanding cancer progression and therapy resistance. This body of work contributes to ongoing efforts in precision oncology and immunotherapy strategies.

Best Publications

  • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

    Zhenbang Chen;Lloyd C. Trotman;David Shaffer;Hui Kuan Lin

  • Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality.

    C.Clifton Ling;John Humm;Steven Larson;Howard Amols

  • Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

    Brett S. Carver;Caren Chapinski;John Wongvipat;Haley Hieronymus

  • Pten dose dictates cancer progression in the prostate.

    Lloyd C Trotman;Masaru Niki;Zohar A Dotan;Jason A Koutcher

  • Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy.

    Kristen L. Zakian;Kanishka Sircar;Hedvig Hricak;Hui Ni Chen

  • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

    Lucia Regales;Yixuan Gong;Ronglai Shen;Elisa de Stanchina

  • Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.

    Juri G. Tjuvajev;Norbert Avril;Takamitsu Oku;Toshio Sasajima

  • Identification of a tumour suppressor network opposing nuclear Akt function

    Lloyd C. Trotman;Andrea Alimonti;Pier Paolo Scaglioni;Jason A. Koutcher

  • Noninvasive Imaging of Herpes Virus Thymidine Kinase Gene Transfer and Expression: A Potential Method for Monitoring Clinical Gene Therapy

    Juri G. Tjuvajev;Ronald Finn;Kyoichi Watanabe;Revathi Joshi

  • Prostate Cancer: Identification with Combined Diffusion-weighted MR Imaging and 3D 1H MR Spectroscopic Imaging—Correlation with Pathologic Findings1

    Yousef Mazaheri;Amita Shukla-Dave;Hedvig Hricak;Samson W. Fine

  • Prostate cancer: correlation of MR imaging and MR spectroscopy with pathologic findings after radiation therapy-initial experience.

    Darko Pucar;Amita Shukla-Dave;Hedvig Hricak;Chaya S. Moskowitz

  • Phase I Study of Intravenous Vascular Endothelial Growth Factor Trap, Aflibercept, in Patients With Advanced Solid Tumors

    A. Craig Lockhart;Mace L. Rothenberg;Jakob Dupont;Wendy Cooper

  • Prostate Tumor Volume Measurement with Combined T2-weighted Imaging and Diffusion-weighted MR: Correlation with Pathologic Tumor Volume

    Yousef Mazaheri;Hedvig Hricak;Samson W. Fine;Oguz Akin

  • CTLA-4 blockade drives loss of T reg stability in glycolysis-low tumours

    Roberta Zappasodi;Inna Serganova;Ivan J. Cohen;Masatomo Maeda

  • Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis.

    Alan H. Shih;Chengkai Dai;Xiaoyi Hu;Marc K. Rosenblum

  • mTOR Promotes Survival and Astrocytic Characteristics Induced by Pten/Akt Signaling in Glioblastoma

    Xiaoyi Hu;Pier Paolo Pandolfi;Yi Li;Jason A. Koutcher

  • Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging--initial results.

    Kristen L. Zakian;Steven Eberhardt;Hedvig Hricak;Amita Shukla-Dave

  • The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis.

    Amita Shukla-Dave;Hedvig Hricak;Michael W. Kattan;Darko Pucar

  • Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.

    Juri G. Tjuvajev;Shu Hsia Chen;Arjun Joshi;Revathi Joshi

  • AMI-227-enhanced MR lymphography: usefulness for differentiating reactive from tumor-bearing lymph nodes.

    Pierre Vassallo;Cornelia Matei;Warren D W Heston;Stuart J. McLachlan

Frequent Co-Authors

Ronald G. Blasberg
Ronald G. Blasberg Memorial Sloan Kettering Cancer Center
Hedvig Hricak
Hedvig Hricak Memorial Sloan Kettering Cancer Center
C. Clifton Ling
C. Clifton Ling Memorial Sloan Kettering Cancer Center
Lawrence H. Schwartz
Lawrence H. Schwartz Columbia University
John L. Humm
John L. Humm Memorial Sloan Kettering Cancer Center
Peter T. Scardino
Peter T. Scardino Memorial Sloan Kettering Cancer Center
Howard T. Thaler
Howard T. Thaler Memorial Sloan Kettering Cancer Center
Victor E. Reuter
Victor E. Reuter Memorial Sloan Kettering Cancer Center
Gloria C. Li
Gloria C. Li Memorial Sloan Kettering Cancer Center
Jacobus F.A. Jansen
Jacobus F.A. Jansen Maastricht University

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