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Samuel Benchimol

Samuel Benchimol

D-Index & Metrics

Molecular Biology

D-Index
52
Citations
12939
World Ranking
2418
National Ranking
76

Overview

Samuel Benchimol is a researcher affiliated with York University in Canada. Their work centers on fields including Medicine, Biochemistry, Genetics and Molecular Biology, with focused subfields in Physiology, Hematology, and Molecular Biology. This interdisciplinary approach supports their exploration of topics related to Telomeres, Telomerase, and Senescence, Acute Myeloid Leukemia Research, and Single-cell and Spatial Transcriptomics.

Their recent scholarly output includes a publication titled Heterogeneity in leukemia cells that escape drug-induced senescence-like state, published in 2023 in the journal Cell Death and Disease. This paper addresses cellular diversity in leukemia that resists drug-induced senescence, contributing to understanding treatment responses in hematologic malignancies.

Samuel Benchimol collaborates frequently with several researchers, reflecting a networked approach to their scientific inquiries. Regular co-authors include:

  • David F. Miller
  • Kyra Kerkhofs
  • Farnoosh Abbas-Aghababazadeh
  • Sahib Singh Madahar
  • Mark D. Minden

Benchimol's contributions have been published primarily in the venue Cell Death and Disease, which aligns with their research focus on cellular and molecular mechanisms underlying disease pathology.

The emphasis on topics such as telomere biology and acute myeloid leukemia reflects a detailed engagement with mechanisms of cellular aging and cancer biology. Their work involving single-cell and spatial transcriptomics techniques indicates a commitment to cutting-edge methodologies for dissecting cellular heterogeneity in disease contexts.

Best Publications

  • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

    Homayoun Vaziri;Samuel Benchimol

  • Regulation of PTEN transcription by p53.

    V. Stambolic;D. MacPherson;D. Sas;Y. Lin

  • p53: oncogene or anti-oncogene?

    David P. Lane;Sam Benchimol

  • Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation

    Roger P. Leng;Yunping Lin;Weili Ma;Hong Wu

  • ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

    Homayoun Vaziri;Michael D. West;Richard C. Allsopp;Timothy S. Davison

  • Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

    Michael Mowat;Michael Mowat;Ambrose Cheng;Ambrose Cheng;Nobuhiro Kimura;Nobuhiro Kimura;Alan Bernstein;Alan Bernstein

  • Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis.

    Yunping Lin;Weili Ma;Samuel Benchimol

  • Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia

    H Ahuja;M Bar-Eli;S H Advani;S Benchimol

  • Translational regulation of human p53 gene expression.

    L. Fu;M. D. Minden;S. Benchimol

  • p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest.

    Jenny S. L. Ho;Weili Ma;Daniel Y. L. Mao;Samuel Benchimol

  • From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging.

    Homayoun Vaziri;Sam Benchimol

  • The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy

    Robert G. Bristow;Samuel Benchimol;Richard P. Hill

  • Transcriptional repression mediated by the p53 tumour suppressor.

    J Ho;S Benchimol

  • p53-dependent pathways of apoptosis

    S Benchimol

  • Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.

    B Rovinski;S Benchimol

  • Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus.

    Ben David Y;Prideaux Vr;Chow;Benchimol S

  • ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.

    Wissam Assaily;Daniel A. Rubinger;Keith Wheaton;Yunping Lin

  • Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.

    P Johnson;D Gray;M Mowat;S Benchimol

  • Ultrasonic biomicroscopy of viable, dead and apoptotic cells

    Gregory J. Czarnota;Gregory J. Czarnota;Michael C. Kolios;Michael C. Kolios;Homayoun Vaziri;Homayoun Vaziri;Sam Benchimol;Sam Benchimol

  • Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin

    P Johnson;S Chung;S Benchimol

Frequent Co-Authors

Richard P. Hill
Richard P. Hill Princess Margaret Cancer Centre
Robert G. Bristow
Robert G. Bristow University of Manchester
Alan Bernstein
Alan Bernstein Canadian Institute for Advanced Research
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Razqallah Hakem
Razqallah Hakem University of Toronto
Suzanne Kamel-Reid
Suzanne Kamel-Reid University Health Network
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Jeremy A. Squire
Jeremy A. Squire Universidade de São Paulo

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