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Bernard W. Futscher

Bernard W. Futscher

D-Index & Metrics

Molecular Biology

D-Index
57
Citations
9438
World Ranking
2164
National Ranking
1074

Overview

Bernard W. Futscher is a researcher affiliated with the University of Arizona in the United States. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these disciplines, their focus concentrates on Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, and Oncology.

Their research covers several main topics, including:

  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Pancreatic and Hepatic Oncology Research
  • Pleural and Pulmonary Diseases
  • Medical Imaging and Pathology Studies
  • Occupational and environmental lung diseases

Bernard W. Futscher has collaborated frequently with a number of co-authors, highlighting ongoing partnerships in their research projects. These collaborators include:

  • Lukáš Vrba
  • Marc M. Oshiro
  • Mark A. Nelson
  • Denise J. Roe
  • George S. Watts

Their recent publications cover advances in cancer diagnostics and epigenetic biomarkers. Representative titles, along with the year of publication and venues, include:

  • "Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease" (2022, Clinical Epigenetics)
  • "DNA methylation changes in biomarker loci occur early in cancer progression" (2020, F1000Research)
  • "Cell-free DNA methylation analysis as a marker of malignancy in pleural fluid" (2024, Scientific Reports)
  • "Detection of pancreatic cancer using a novel blood-based DNA methylation signature" (2020, Journal of Clinical Oncology)
  • "Identification and transcriptional regulation of the mir-218-1 alternative promoter" (2020, bioRxiv (Cold Spring Harbor Laboratory))

Their publications appear across a variety of venues that include bioRxiv (Cold Spring Harbor Laboratory), Clinical Epigenetics, Scientific Reports, F1000Research, and Journal of Clinical Oncology.

Best Publications

  • Role for DNA methylation in the control of cell type specific maspin expression.

    Bernard W. Futscher;Marc M. Oshiro;Ryan J. Wozniak;Nicholas Holtan

  • P-glycoprotein expression and function in circulating blood cells from normal volunteers

    Walter T. Klimecki;Bernard W. Futscher;Thomas M. Grogan;William S. Dalton

  • Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

    A F List;C Spier;J Greer;S Wolff

  • Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

    Lukas Vrba;Taylor J. Jensen;James C. Garbe;Ronald L. Heimark

  • Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

    George S. Watts;Russell O. Pieper;Joseph F. Costello;Yei Mei Peng

  • Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

    Judd C Rice;Kathy S Massey-Brown;Bernard W Futscher

  • Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

    Judd C. Rice;Hilmi Ozcelik;Hilmi Ozcelik;Patrick Maxeiner;Irene Andrulis;Irene Andrulis

  • Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells

    Joseph F. Costello;Bernard W. Futscher;Keizo Tano;Dawn M. Graunke

  • Epigenetic silencing of maspin gene expression in human breast cancers.

    Frederick E. Domann;Judd C. Rice;Mary J.C. Hendrix;Bernard W. Futscher

  • 5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation

    R J Wozniak;W T Klimecki;S S Lau;Y Feinstein

  • Agglomerative Epigenetic Aberrations Are a Common Event in Human Breast Cancer

    Petr Novak;Taylor Jensen;Marc M. Oshiro;George S. Watts

  • Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization

    Petr Novak;Petr Novak;Taylor J. Jensen;James C. Garbe;Martha R. Stampfer;Martha R. Stampfer

  • miRNA Gene Promoters Are Frequent Targets of Aberrant DNA Methylation in Human Breast Cancer

    Lukas Vrba;José L. Muñoz-Rodríguez;Martha R. Stampfer;Martha R. Stampfer;Bernard W. Futscher

  • Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors

    M A Nelson;B W Futscher;T Kinsella;J Wymer

  • Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines.

    Joseph F. Costello;Bernard W. Futscher;Roger A. Kroes;Russell O. Pieper

  • Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells.

    Mohammad R. Abbaszadegan;Bernard W. Futscher;Walter T. Klimecki;Alan List

  • EPIGENETIC REMODELING DURING ARSENICAL-INDUCED MALIGNANT TRANSFORMATION

    Taylor J. Jensen;Petr Novak;Kylee E. Eblin;A. Jay Gandolfi

  • Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression

    Marc M Oshiro;George S Watts;Ryan J Wozniak;Damian J Junk

  • Epigenetic inactivation of the HOXA gene cluster in breast cancer.

    Petr Novak;Taylor Jensen;Marc M. Oshiro;Ryan J. Wozniak

  • Epigenetic silencing of DSC3 is a common event in human breast cancer

    Marc M Oshiro;Christina J Kim;Ryan J Wozniak;Damian J Junk

Frequent Co-Authors

Frederick E. Domann
Frederick E. Domann University of Iowa
Martha R. Stampfer
Martha R. Stampfer Lawrence Berkeley National Laboratory
William S. Dalton
William S. Dalton University of South Florida
Russell O. Pieper
Russell O. Pieper University of California, San Francisco
Joseph F. Costello
Joseph F. Costello University of California, San Francisco
Alan F. List
Alan F. List Precision BioSciences
Michael P. Waalkes
Michael P. Waalkes National Institutes of Health
Sydney E. Salmon
Sydney E. Salmon University of Arizona
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
Zuzana Storchova
Zuzana Storchova Technical University of Kaiserslautern

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