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Medicine

D-Index
86
Citations
26276
World Ranking
14160
National Ranking
586

Research.com Recognitions

  • 2016 - Robert L. Noble Prize, Canadian Cancer Society

Overview

Poul H Sorensen is a researcher affiliated with the University of British Columbia in Canada. Their work spans key areas in biochemistry, genetics, molecular biology, and medicine, with significant contributions to oncology and immunology. Their research frequently addresses molecular biology topics with a focus on cancer research, genetics, and immune cell interactions.

Their recent research includes notable papers published in high-impact journals. Key publications are:

  • Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors (2020, Nature Medicine)
  • Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma (2020, Nature Medicine)
  • Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication (2022, Nature Medicine)
  • GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity (2021, Cancer Cell)
  • Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma (2020, Cell)

Their primary fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of particular focus are:

  • Molecular Biology
  • Oncology
  • Immunology
  • Cancer Research
  • Genetics

The main research topics that characterize their work consist of:

  • CAR-T cell therapy research
  • Neuroblastoma Research and Treatments
  • Glioma Diagnosis and Treatment
  • Epigenetics and DNA Methylation
  • Cancer, Hypoxia, and Metabolism
  • Immune Cell Function and Interaction
  • RNA modifications and cancer

Frequent publication venues for their work include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Clinical Cancer Research
  • Nature Medicine

Poul H Sorensen collaborates extensively with several researchers, including:

  • Alberto Delaidelli
  • Gian Luca Negri
  • Mads Daugaard
  • John M. Maris
  • Michael M. Lizardo

In 2016, Sorensen was awarded the Robert L. Noble Prize by the Canadian Cancer Society, acknowledging a significant contribution to cancer research.

Best Publications

  • Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.

    Cristina Tognon;Stevan R Knezevich;David Huntsman;Calvin D Roskelley

  • Lin28 promotes transformation and is associated with advanced human malignancies

    Srinivas R Viswanathan;John T Powers;William Einhorn;Yujin Hoshida

  • A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

    Poul H.B. Sorensen;Stephen L. Lessnick;Dolores Lopez-Terrada;Xian F. Liu

  • PAX3-FKHR and PAX7-FKHR Gene Fusions Are Prognostic Indicators in Alveolar Rhabdomyosarcoma: A Report From the Children’s Oncology Group

    Poul H B Sorensen;James C Lynch;Stephen J Qualman;Roberto Tirabosco

  • Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

    Cheryl D. Helgason;Jacqueline E. Damen;Patty Rosten;Rewa Grewal

  • CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.

    Robbie G. Majzner;Johanna L. Theruvath;Anandani Nellan;Sabine Heitzeneder

  • The der(17)t(x;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25

    Marc Ladanyi;Man Yee Lui;Cristina R Antonescu;Amber Krause-Boehm

  • Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

    Valentina Evdokimova;Cristina Tognon;Tony Ng;Peter Ruzanov

  • Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers

    Alireza Heravi-Moussavi;Michael S Anglesio;S-W Grace Cheng;Janine Senz

  • The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

    Gabriel Leprivier;Marc Remke;Marc Remke;Barak Rotblat;Adrian Dubuc

  • The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

    Philipp Kapranov;Georges St Laurent;Georges St Laurent;Tal Raz;Fatih Ozsolak

  • Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.

    Valentina Evdokimova;Peter Ruzanov;Michael S. Anglesio;Alexey V. Sorokin

  • Molecular Classification of Rhabdomyosarcoma-Genotypic and Phenotypic Determinants of Diagnosis : A Report from the Children's Oncology Group

    Elai Davicioni;Michael J. Anderson;Michael J. Anderson;Friedrich Graf Finckenstein;James C. Lynch

  • Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

    Amal M. El-Naggar;Chansey J. Veinotte;Hongwei Cheng;Thomas G.P. Grunewald

  • YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.

    Syam Prakash Somasekharan;Syam Prakash Somasekharan;Amal El-Naggar;Amal El-Naggar;Gabriel Leprivier;Hongwei Cheng

  • Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization.

    Scott M. Welford;Jeffrey Gregg;Emily Chen;Darryl Garrison

  • Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

    Ali Salanti;Thomas M Clausen;Mette Ø Agerbæk;Nader Al Nakouzi;Nader Al Nakouzi

  • E-Cadherin Cell-Cell Adhesion in Ewing Tumor Cells Mediates Suppression of Anoikis through Activation of the ErbB4 Tyrosine Kinase

    Hyung-Gyoo Kang;Jasmine M. Jenabi;Jingsong Zhang;Nino Keshelava

  • Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

    Johanna Theruvath;Elena Sotillo;Christopher W. Mount;Claus Moritz Graef

  • Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood

    Poul H.B. Sorensen;Xian Fang Liu;Olivier Delattre;Jon M. Rowland

Frequent Co-Authors

Martin Hirst
Martin Hirst University of British Columbia
Crystal L. Mackall
Crystal L. Mackall Stanford University
Gregg B. Morin
Gregg B. Morin University of British Columbia
Connie J. Eaves
Connie J. Eaves University of British Columbia
John M. Maris
John M. Maris Children's Hospital of Philadelphia
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
David M. Barrett
David M. Barrett Children's Hospital of Philadelphia
David T. Teachey
David T. Teachey Children's Hospital of Philadelphia
Dimiter S. Dimitrov
Dimiter S. Dimitrov University of Pittsburgh
Rimas J. Orentas
Rimas J. Orentas University of Washington

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