Hiromi Fujiwara

Overview

Best Publications

• T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

  Hidekazu Mizuhara;Elaine O'Neill;Nobuo Seki;Toshikazu Ogawa

  783
  Citations

• A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.

  H J Ahn;S Maruo;M Tomura;J Mu

  458
  Citations

• Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity.

  N Seki;Y Sudo;T Yoshioka;S Sugihara

  376
  Citations

• Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

  T. Tada;S. Ohzeki;K. Utsumi;H. Takiuchi

  370
  Citations

• Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

  Masakiyo Nakahira;Hyun Jong Ahn;Woong Ryeon Park;Ping Gao

  368
  Citations

• A pivotal involvement of IFN-γ in the pathogenesis of acetaminophen-induced acute liver injury

  Yuko Ishida;Toshikazu Kondo;Tohru Ohshima;Hiromi Fujiwara

  301
  Citations

• A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

  Michio Tomura;Wen-Gong Yu;Hyun-Jong Ahn;Motozo Yamashita

  300
  Citations

• Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells

  Jian-Ping Zou;Norihiko Yamamoto;Tetsuya Fujii;Hiroshi Takenaka

  296
  Citations

• Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis.

  H Mizuhara;M Uno;N Seki;M Yamashita

  267
  Citations

• Enhanced Induction of Antitumor T-Cell Responses by Cytotoxic T Lymphocyte-associated Molecule-4 Blockade: The Effect Is Manifested Only at the Restricted Tumor-bearing Stages

  Yi Fu Yang;Jian Ping Zou;Jie Mu;Rishani Wijesuriya

  259
  Citations

• The role of tumor-specific Lyt-1+2- T cells in eradicating tumor cells in vivo. I. Lyt-1+2- T cells do not necessarily require recruitment of host's cytotoxic T cell precursors for implementation of in vivo immunity.

  H Fujiwara;M Fukuzawa;T Yoshioka;H Nakajima

  221
  Citations

• Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts.

  Yumi Yashiro-Ohtani;Xu-Yu Zhou;Kazuhito Toyo-oka;Xu-Guang Tai

  217
  Citations

• Administration of Recombinant Interleukin 12 Prevents Outgrowth of Tumor Cells Metastasizing Spontaneously to Lung and Lymph Nodes

  Jie Mu;Jian-Ping Zou;Norihiko Yamamoto;Tateki Tsutsui

  199
  Citations

• A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3− Cells

  Michio Tomura;Xu-Yu Zhou;Seiji Maruo;Hyun-Jong Ahn

  195
  Citations

• Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.

  Michio Tomura;Seiji Maruo;Jie Mu;Xu-Yu Zhou

  171
  Citations

• The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3

  Ping Gao;Xu Yu Zhou;Yumi Yashiro-Ohtani;Yi Fu Yang

  157
  Citations

• A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice.

  Chigusa Nakajima;Yasuhiro Uekusa;Masayuki Iwasaki;Nobuya Yamaguchi

  150
  Citations

• Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-γ stimulation

  Chigusa Nakajima;Takao Mukai;Nobuya Yamaguchi;Yasunari Morimoto

  149
  Citations

• Induction of tolerance to topically applied TNCB using TNP-conjugated ultraviolet light-irradiated epidermal cells.

  D N Sauder;K Tamaki;A N Moshell;H Fujiwara

  147
  Citations

• HIV Entry Inhibitor TAK-779 Attenuates Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

  Eva J.A. van Wanrooij;Hester Happé;Arnaud D. Hauer;Paula de Vos

  145
  Citations

• Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12.

  Wen-Gong Yu;Noriniko Yamamoto;Hiroshi Takenaka;Jie Mu

  140
  Citations