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Molecular Biology

D-Index
50
Citations
28750
World Ranking
2523
National Ranking
195

Overview

Ian Chambers is affiliated with the University of Edinburgh in the United Kingdom. Their primary field of study is Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology among related subfields. Their research spans multiple subfields including Surgery, Biomedical Engineering, and Genetics.

The scientist's work centers on several key topics in biomedical research, notably:

  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering
  • Epigenetics and DNA Methylation
  • Renal and related cancers
  • Tissue Engineering and Regenerative Medicine
  • Cancer-related gene regulation
  • Genomics and Chromatin Dynamics

Ian Chambers has contributed to a range of research articles published in reputable scientific journals. Some of their recent papers include:

  • Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells, 2024, Developmental Cell
  • Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage, 2021, Development
  • Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry, 2021, Stem Cell Reports
  • Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal, 2020, FEBS Letters
  • TET1 Interacts Directly with NANOG via Independent Domains Containing Hydrophobic and Aromatic Residues, 2020, Journal of Molecular Biology

Their frequent coauthors include Man Zhang, Elisa Barbieri, Nicholas P. Mullin, Matúš Vojtek, and Douglas Colby.

The most frequent venues for Ian Chambers' publications are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Developmental Cell
  • Development
  • Stem Cell Reports

Best Publications

  • Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

    Jennifer Nichols;Branko Zevnik;Konstantinos Anastassiadis;Hitoshi Niwa

  • FUNCTIONAL EXPRESSION CLONING OF NANOG, A PLURIPOTENCY SUSTAINING FACTOR IN EMBRYONIC STEM CELLS

    Ian Chambers;Douglas Colby;Morag Robertson;Jennifer Nichols

  • BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

    Qi Long Ying;Jennifer Nichols;Ian Chambers;Austin Smith

  • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

    Hitoshi Niwa;Tom Burdon;Ian Chambers;Austin G Smith

  • Nanog safeguards pluripotency and mediates germline development.

    Ian Chambers;Jose Silva;Douglas Colby;Jennifer Nichols;Jennifer Nichols

  • Nanog is the gateway to the pluripotent ground state.

    Jose Silva;Jose Silva;Jennifer Nichols;Jennifer Nichols;Thorold W. Theunissen;Thorold W. Theunissen;Ge Guo;Ge Guo

  • The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA.

    I Chambers;J Frampton;P Goldfarb;N Affara

  • Self-renewal of teratocarcinoma and embryonic stem cells

    Ian Chambers;Austin G Smith

  • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

    Tom Burdon;Craig Stracey;Ian Chambers;Jennifer Nichols

  • An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

    Debbie L.C. van den Berg;Tim Snoek;Nick P. Mullin;Adam Yates

  • The transcriptional foundation of pluripotency.

    Ian Chambers;Simon R. Tomlinson

  • Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

    Jerome Aubert;Hannah Dunstan;Ian Chambers;Austin G Smith

  • Nanog promotes transfer of pluripotency after cell fusion.

    José Silva;Ian Chambers;Steven Pollard;Austin Smith;Austin Smith

  • Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.

    Hitoshi Niwa;Hitoshi Niwa;Shinji Masui;Ian Chambers;Austin G. Smith

  • Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells

    Nicola Festuccia;Rodrigo Osorno;Florian Halbritter;Violetta Karwacki-Neisius

  • Molecular Coupling of Xist Regulation and Pluripotency

    Pablo Navarro;Ian Chambers;Violetta Karwacki-Neisius;Corinne Chureau

  • Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

    Peter Mountford;Branko Zevnik;Annette Duwel;Jennifer Nichols

  • Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines

    Jennifer Nichols;Ian Chambers;Tetsuya Taga;Austin Smith

  • Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

    Kanji Yoshida;Ian Chambers;Jennifer Nichols;Austin Smith

  • The pluripotent genome in three dimensions is shaped around pluripotency factors

    Elzo de Wit;Britta A. M. Bouwman;Yun Zhu;Petra Klous

Frequent Co-Authors

Austin Smith
Austin Smith University of Exeter
Jennifer Nichols
Jennifer Nichols University of Cambridge
Hitoshi Niwa
Hitoshi Niwa Kumamoto University
Jon Frampton
Jon Frampton University of Birmingham
Christian Dani
Christian Dani Université Côte d'Azur
Hans R. Schöler
Hans R. Schöler Max Planck Society
Paul Robson
Paul Robson University of Connecticut
Dario Acampora
Dario Acampora King's College London
Philip Avner
Philip Avner European Bioinformatics Institute
Antonio Simeone
Antonio Simeone King's College London

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