Embryonic stem cell, Cell biology, Molecular biology, Transcription factor and Cellular differentiation are his primary areas of study. Hitoshi Niwa interconnects Stem cell and Inner cell mass in the investigation of issues within Embryonic stem cell. His Cell biology research integrates issues from Inhibitory postsynaptic potential, Immunology, Germline and Leukemia inhibitory factor.
His research in Molecular biology intersects with topics in Cell culture, SOX2, Promoter, Reporter gene and Embryoid body. As part of his studies on Cellular differentiation, Hitoshi Niwa often connects relevant subjects like Oct-4. The various areas that Hitoshi Niwa examines in his Rex1 study include Cell potency, Nanog Homeobox Protein and Homeobox protein NANOG.
His main research concerns Cell biology, Embryonic stem cell, Molecular biology, Anesthesia and Cellular differentiation. His Cell biology research is multidisciplinary, relying on both Cell potency, Reprogramming, Immunology and Somatic cell. His Embryonic stem cell research is multidisciplinary, incorporating elements of Transcription factor and Stem cell.
His Molecular biology study incorporates themes from Cell culture, Inner cell mass, Gene, Transgene and Embryo. His Anesthesia study combines topics in areas such as Surgery and Blood pressure. His biological study spans a wide range of topics, including Nanog Homeobox Protein and Homeobox protein NANOG.
His scientific interests lie mostly in Cell biology, Embryonic stem cell, Anesthesia, Surgery and Cell. Hitoshi Niwa studies Stem cell, a branch of Cell biology. The Stem cell study combines topics in areas such as Germ layer and Endoderm.
The study incorporates disciplines such as Reprogramming, Epigenetics and Cellular differentiation in addition to Embryonic stem cell. His Cell research incorporates elements of Hippo signaling pathway, Cell culture, ASCL1 and Carcinogenesis. His work deals with themes such as Regulation of gene expression and Germ cell, which intersect with Transcription factor.
Hitoshi Niwa spends much of his time researching Cell biology, Embryonic stem cell, Induced pluripotent stem cell, Transcription factor and Reprogramming. Specifically, his work in Cell biology is concerned with the study of Stem cell. His Stem cell study integrates concerns from other disciplines, such as Germ layer and MAPK/ERK pathway.
His research in Embryonic stem cell is mostly focused on Rex1. His research integrates issues of SOX2, Evolutionary biology, Function and G protein in his study of Induced pluripotent stem cell. His Transcription factor research includes themes of Regulation of gene expression, Mitosis, Retinoic acid and Germ cell.
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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
Hitoshi Niwa;Jun-ichi Miyazaki;Austin G. Smith.
Nature Genetics (2000)
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
Jennifer Nichols;Branko Zevnik;Konstantinos Anastassiadis;Hitoshi Niwa.
Cell (1998)
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
Hitoshi Niwa;Tom Burdon;Ian Chambers;Austin G Smith.
Genes & Development (1998)
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Shinji Masui;Yuhki Nakatake;Yayoi Toyooka;Daisuke Shimosato.
Nature Cell Biology (2007)
Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation
Hitoshi Niwa;Yayoi Toyooka;Daisuke Shimosato;Dan Strumpf.
Cell (2005)
How is pluripotency determined and maintained
Hitoshi Niwa.
Development (2007)
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
Hitoshi Niwa;Kazuya Ogawa;Daisuke Shimosato;Kenjiro Adachi.
Nature (2009)
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
Noriyuki Nishioka;Ken ichi Inoue;Kenjiro Adachi;Hiroshi Kiyonari.
Developmental Cell (2009)
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.
Martha Hotz Vitaterna;Christopher P. Selby;Takeshi Todo;Hitoshi Niwa.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Genome analysis of the platypus reveals unique signatures of evolution
Wesley C. Warren;La Deana W. Hillier;Jennifer A. Marshall Graves;Ewan Birney.
Nature (2008)
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