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Minoru S.H. Ko

Minoru S.H. Ko

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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
77
Citations
21589
World Ranking
1112
National Ranking
90

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Minoru S.H. Ko is affiliated with Keio University in Japan. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. Their subfields of study include Molecular Biology, Infectious Diseases, Physiology, Genetics, and Animal Science and Zoology.

The scientist's work covers various topics such as SARS-CoV-2 and COVID-19 Research, CRISPR and Genetic Engineering, Pluripotent Stem Cells Research, RNA Interference and Gene Delivery, Animal Virus Infections Studies, Telomeres, Telomerase, and Senescence, and Epigenetics and DNA Methylation.

Minoru S.H. Ko has published extensively, contributing papers to several notable venues. Frequent venues where their work appears include bioRxiv (Cold Spring Harbor Laboratory), iScience, Developmental Cell, Cell Reports, and Nature Communications.

Recent notable papers are:

  • MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells (2020) in Developmental Cell
  • Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells (2020) in iScience
  • Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors (2020) in Cell Reports
  • Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity (2023) in iScience
  • SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors (2023) in Nature Communications

Coauthorship is an important aspect of their research, with frequent collaborators including:

  • Tomohiko Akiyama
  • Tomokazu Amano
  • Misa Amano
  • Akihiro C. Ko
  • Nan-ping Weng

Minoru S.H. Ko's publications demonstrate a multidisciplinary approach combining molecular biology techniques with infectious disease research and stem cell studies. The range of topics spans from fundamental mechanisms like genetic control of meiosis and fatty acid synthesis in stem cells to applied immunological research in viral infections and vaccine development.

Best Publications

  • Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells

    Shinji Masui;Yuhki Nakatake;Yayoi Toyooka;Daisuke Shimosato

  • Dynamics of Global Gene Expression Changes during Mouse Preimplantation Development

    Toshio Hamatani;Mark G. Carter;Alexei A. Sharov;Minoru S.H. Ko

  • Maps from two interspecific backcross DNA panels available as a community genetic mapping resource

    L. B. Rowe;J. H. Nadeau;R. Turner;W. N. Frankel

  • The status, quality, and expansion of the NIH full-length cDNA project: The Mammalian Gene Collection (MGC)

    Daniela S. Gerhard;Lukas Wagner;Elise A. Feingold;Carolyn M. Shenmen

  • Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

    Lioudmila V. Sharova;Alexei A. Sharov;Timur Nedorezov;Yulan Piao

  • Age-associated alteration of gene expression patterns in mouse oocytes

    Toshio Hamatani;Geppino Falco;Mark G. Carter;Hidenori Akutsu

  • Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

    Makoto Noda;Minoru Ko;Akihiko Ogura;Ding Gan Liu

  • Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

    Tetsuya S. Tanaka;Saied A. Jaradat;Meng K. Lim;George J. Kargul

  • AGEMAP: a gene expression database for aging in mice.

    Jacob M Zahn;Suresh Poosala;Art B Owen;Donald K Ingram

  • The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

    Anand K. Srivastava;Johanna Pispa;Andrew J. Hartung;Yangzhu Du

  • Zscan4 regulates telomere elongation and genomic stability in ES cells

    Michal Zalzman;Geppino Falco;Lioudmila V. Sharova;Akira Nishiyama

  • Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice

    Takashi Sakatani;Atsushi Kaneda;Christine A. Iacobuzio-Donahue;Mark G. Carter

  • SCODE: an efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation.

    Hirotaka Matsumoto;Hisanori Kiryu;Chikara Furusawa;Minoru S H Ko

  • Klf4 Cooperates with Oct3/4 and Sox2 To Activate the Lefty1 Core Promoter in Embryonic Stem Cells

    Yuhki Nakatake;Nobutaka Fukui;Yuko Iwamatsu;Shinji Masui

  • Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells

    Geppino Falco;Sung Lim Lee;Ilaria Stanghellini;Uwem C. Bassey

  • Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development

    M.S. Ko;J.R. Kitchen;X. Wang;T.A. Threat

  • Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript.

    Maurice A. Canham;Alexei A. Sharov;Minoru S. H. Ko;Joshua M. Brickman

  • Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation

    Toshio Hamatani;Takiko Daikoku;Haibin Wang;Hiromichi Matsumoto

  • Evaluation and comparison of clustering algorithms in analyzing es cell gene expression data

    Gengxin Chen;Saied A. Jaradat;Nila Banerjee;Tetsuya S. Tanaka

  • A stochastic model for gene induction.

    Minoru S.H. Ko

Frequent Co-Authors

David Schlessinger
David Schlessinger National Institutes of Health
Dan L. Longo
Dan L. Longo Harvard University
Hitoshi Niwa
Hitoshi Niwa Kumamoto University
Akira Nishiyama
Akira Nishiyama Kagawa University
Kevin G. Becker
Kevin G. Becker National Institutes of Health
Yixian Zheng
Yixian Zheng Carnegie Institution for Science
Andrew P. Feinberg
Andrew P. Feinberg Johns Hopkins University
Chen-Ming Fan
Chen-Ming Fan Carnegie Institution for Science
Tomohiko Tamura
Tomohiko Tamura Yokohama City University
Takahiro Kunisada
Takahiro Kunisada Gifu University

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