World's Best Scientists 2026 revealed!

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Medicine

D-Index
114
Citations
47636
World Ranking
4739
National Ranking
2568

Overview

Edward A. Sausville is affiliated with the University of Maryland, Baltimore in the United States. Their research spans multiple fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several specialized subfields such as Molecular Biology, Oncology, Hepatology, Pulmonary and Respiratory Medicine, and Pathology and Forensic Medicine.

The primary topics covered in their work involve hepatocellular carcinoma treatment and prognosis, cell death mechanisms and regulation, pancreatic and hepatic oncology research, sarcoma diagnosis and treatment, CAR-T cell therapy research, lymphoma diagnosis and treatment, and viral-associated cancers and disorders.

Some of their recent publications include:

  • Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort, 2024, Investigational New Drugs
  • Results of an Integrated Phase I/II Prospective Clinical Trial (NEXIS) for Neoadjuvant Anti-PD-L1 (Durvalumab) and Anti-CTLA-4 (Tremelimumab) With Radiation for High-Risk Soft-Tissue Sarcoma of the Trunk and Extremities, 2024, Cureus
  • Inhibition of Mitochondrial Respiration as a Source of Adaphostin-induced Reactive Oxygen Species and Cytotoxicity, 2021, UNC Libraries
  • Replacement of Antiretroviral Therapy with HIV Broadly Neutralizing Antibodies to Maximize the Effectiveness of Chemotherapy in HIV Patients with Lung Cancer, 2023, AIDS Research and Human Retroviruses
  • Editor's Note: Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator, 2024, Clinical Cancer Research

Frequent coauthors in their research include:

  • Scott H. Kaufmann
  • Oluwadunni E. Emiloju
  • Jun Yin
  • Emily J. Koubek
  • Joel M. Reid

Edward A. Sausville has published regularly in journals such as:

  • Investigational New Drugs
  • Cureus
  • UNC Libraries
  • AIDS Research and Human Retroviruses
  • Clinical Cancer Research

Best Publications

  • Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents

    Julian Adams;Vito J. Palombella;Edward A. Sausville;Jill Johnson

  • A gene expression database for the molecular pharmacology of cancer

    Uwe Scherf;Douglas T. Ross;Mark Waltham;Lawrence H. Smith

  • An Information-Intensive Approach to the Molecular Pharmacology of Cancer

    John N. Weinstein;Timothy G. Myers;Patrick M. O'Connor;Stephen H. Friend

  • L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.

    Marion M. Nau;Burke J. Brooks;James Battey;Edward Sausville

  • Flavopiridol Induces G1 Arrest with Inhibition of Cyclin-dependent Kinase (CDK) 2 and CDK4 in Human Breast Carcinoma Cells

    Bradley A. Carlson;Marja M. Dubay;Edward A. Sausville;Leonardo Brizuela

  • Issues and progress with protein kinase inhibitors for cancer treatment

    Janet Dancey;Edward A. Sausville

  • Osteonecrosis of the Jaw in Multiple Myeloma Patients: Clinical Features and Risk Factors

    Ashraf Badros;Dianna Weikel;Andrew Salama;Olga Goloubeva

  • Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

    Adrian M. Senderowicz;Edward A. Sausville

  • Novel Proteasome Inhibitor PS-341 Inhibits Activation of Nuclear Factor-κB, Cell Survival, Tumor Growth, and Angiogenesis in Squamous Cell Carcinoma

    John B. Sunwoo;Zhong Chen;Gang Dong;Ning Yeh

  • The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

    Paul R. Graves;Lijia Yu;Julie K. Schwarz;Janis Gales

  • UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

    Qizhi Wang;Saijun Fan;Alan Eastman;Peter J. Worland

  • Identification of Small Molecule Inhibitors of Hypoxia-inducible Factor 1 Transcriptional Activation Pathway

    Annamaria Rapisarda;Badarch Uranchimeg;Dominic A. Scudiero;Mike Selby

  • Contributions of Human Tumor Xenografts to Anticancer Drug Development

    Edward A. Sausville;Angelika M. Burger

  • A randomized trial comparing combination electron-beam radiation and chemotherapy with topical therapy in the initial treatment of mycosis fungoides.

    Kaye Fj;Bunn Pa;Steinberg Sm;Stocker Jl

  • Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation

    Sudhir B Kondapaka;Sheo S Singh;Girija P Dasmahapatra;Edward A Sausville

  • Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

    Aaron D. Schimmer;Kate Welsh;Clemencia Pinilla;Zhiliang Wang

  • Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents

    Brian K. Adams;Eva M. Ferstl;Matthew C. Davis;Marike Herold

  • Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

    A M Senderowicz;D Headlee;S F Stinson;R M Lush

  • Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma

    Qin C. Ryan;Donna Headlee;Milin Acharya;Alex Sparreboom

  • Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.

    Lloyd T Lam;Oxana K Pickeral;Amy C Peng;Andreas Rosenwald

Frequent Co-Authors

William D. Figg
William D. Figg National Institutes of Health
Patricia LoRusso
Patricia LoRusso Yale University
Maria R. Baer
Maria R. Baer University of Maryland, Baltimore
Jane B. Trepel
Jane B. Trepel National Institutes of Health
Robert H. Shoemaker
Robert H. Shoemaker National Institutes of Health
Dominic A. Scudiero
Dominic A. Scudiero Science Applications International Corporation (United States)
Robert R. Redfield
Robert R. Redfield Centers for Disease Control and Prevention
Alex Sparreboom
Alex Sparreboom The Ohio State University
Christopher P. Leamon
Christopher P. Leamon Fusion Pharmaceuticals
Laurent Meijer
Laurent Meijer Perha Pharmaceuticals

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