World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
87
Citations
25737
World Ranking
804
National Ranking
75

Research.com Recognitions

  • 2004 - Fellow of the Royal Society, United Kingdom

Overview

David W. Holden is affiliated with Imperial College London in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific focus on Oncology, Genetics, Pathology and Forensic Medicine, Food Science, and Endocrinology.

The scientist's main topics of work include:

  • Multiple Sclerosis Research Studies
  • Salmonella and Campylobacter epidemiology
  • Polyomavirus and related diseases
  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions
  • Cancer Research and Treatments
  • Escherichia coli research studies

David W. Holden has contributed to several recent publications. Notable papers include:

  • "Global mapping of Salmonella enterica-host protein-protein interactions during infection," 2021, Cell Host & Microbe
  • "The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules," 2020, Cell Host & Microbe
  • "CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD," 2021, PLoS Pathogens
  • "CSF neurofilament light chain testing as an aid to determine treatment strategies in MS," 2020, Neurology Neuroimmunology & Neuroinflammation
  • "Structure of the cytoplasmic domain of SctV (SsaV) from the Salmonella SPI-2 injectisome and implications for a pH sensing mechanism," 2021, Journal of Structural Biology

Frequent coauthors collaborating with David W. Holden include:

  • Gavin Giovannoni
  • Sharmilee Gnanapavan
  • Klaus Schmierer
  • Lucia Bianchi
  • Francesca Ammoscato

Their work appears regularly in several publication venues, with multiple contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Host & Microbe
  • PLoS Pathogens
  • Multiple Sclerosis and Related Disorders
  • Microbiology

In 2004, David W. Holden was awarded the distinction of Fellow of the Royal Society, United Kingdom.

Best Publications

  • Simultaneous identification of bacterial virulence genes by negative selection

    Michael Hensel;Jacqueline E. Shea;Colin Gleeson;Michael D. Jones

  • Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium

    Jacqueline E. Shea;Michael Hensel;Colin Gleeson;David W. Holden

  • Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages

    Michael Hensel;Jacqueline E. Shea;Scott R. Waterman;Rosanna Mundy

  • Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

    Sophie Helaine;Angela M. Cheverton;Kathryn G. Watson;Laura M. Faure

  • Salmonella maintains the integrity of its intracellular vacuole through the action of SifA.

    Carmen R. Beuzón;Stéphane Méresse;Kate E. Unsworth;Javier Ruíz-Albert

  • Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.

    Andrés Vazquez-Torres;Yisheng Xu;Jessica Jones-Carson;David W. Holden

  • Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis

    Ji-Min Mei;Fahimeh Nourbakhsh;Charles W. Ford;David W. Holden

  • A pneumococcal pilus influences virulence and host inflammatory responses

    M A Barocchi;J Ries;X Zogaj;C Hemsley

  • Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system.

    Scott R Waterman;David W Holden

  • Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences.

    Elliott Jennings;Teresa L.M. Thurston;David W. Holden

  • The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

    Jeremy S. Brown;Tracy Hussell;Sarah M. Gilliland;David W. Holden

  • Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors.

    Unknown

  • A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence

    Jeremy S. Brown;Sarah M. Gilliland;David W. Holden

  • Dynamics of intracellular bacterial replication at the single cell level

    Unknown

  • A functional genomic analysis of type 3 Streptococcus pneumoniae virulence.

    Gee W. Lau;Sauli Haataja;Michael Lonetto;Sarah E. Kensit

  • Gene transfer system for the phytopathogenic fungus Ustilago maydis

    Jun Wang;David W. Holden;Sally A. Leong

  • Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membrane

    Javier Ruiz-Albert;Xiu-Jun Yu;Carmen R. Beuzón;Abigail N. Blakey

  • Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo.

    Suzana P. Salcedo;Mahdad Noursadeghi;Jonathan Cohen;David W. Holden

  • SseL, a Salmonella deubiquitinase required for macrophage killing and virulence

    Anne Rytkönen;John Poh;Junkal Garmendia;Cliona Boyle

  • In Vivo Genetic Analysis of Bacterial Virulence

    Su L. Chiang;John J. Mekalanos;David W. Holden

  • PH-DEPENDENT SECRETION OF SSEB, A PRODUCT OF THE SPI-2 TYPE III SECRETION SYSTEM OF SALMONELLA TYPHIMURIUM

    Carmen R. Beuzón;Geoff Banks;Jörg Deiwick;Michael Hensel

  • Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers.

    Zoë Hindle;Steven N. Chatfield;Jo Phillimore;Matthew Bentley

  • Salmonella Pathogenicity Island 2—Dependent Evasion of the

    Yisheng Xu;Jessica Jones-Carson;David W. Holden;Scott M. Lucia

Frequent Co-Authors

Michael Hensel
Michael Hensel Osnabrück University
Herbert N. Arst
Herbert N. Arst Imperial College London
Ferric C. Fang
Ferric C. Fang University of Washington
James C. Paton
James C. Paton University of Adelaide
Gordon Dougan
Gordon Dougan University of Cambridge
Christoph M. Tang
Christoph M. Tang University of Oxford
David Komander
David Komander Walter and Eliza Hall Institute of Medical Research
Stéphane Méresse
Stéphane Méresse Centre d’Immunologie de Marseille-Luminy
Hein te Riele
Hein te Riele Netherlands Cancer Institute
Gad Frankel
Gad Frankel Imperial College London

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