2004 - Fellow of the Royal Society, United Kingdom
His primary areas of study are Microbiology, Virulence, Pathogenicity island, Type three secretion system and Mutant. His Microbiology research incorporates themes from Salmonella, Bacteria, Intracellular, Lectin pathway and Complement membrane attack complex. His Virulence study is concerned with Genetics in general.
His biological study spans a wide range of topics, including Streptococcus pneumoniae and Locus. His biological study spans a wide range of topics, including Vacuole and Effector. His Effector study also includes fields such as
David W. Holden spends much of his time researching Microbiology, Virulence, Type three secretion system, Cell biology and Effector. His Microbiology research incorporates themes from Salmonella, Salmonella enterica, Pathogenicity island, Bacteria and Intracellular. His research integrates issues of Mutagenesis, Mutant and Streptococcus pneumoniae in his study of Virulence.
His Type three secretion system research includes elements of Entry into host and Host cell cytosol, Vacuole, Cytosol. His Cell biology research is multidisciplinary, incorporating elements of Actin cytoskeleton and Programmed cell death. As part of the same scientific family, he usually focuses on Effector, concentrating on Secretion and intersecting with Innate immune system.
His scientific interests lie mostly in Effector, Cell biology, Microbiology, Type three secretion system and Secretion. The concepts of his Effector study are interwoven with issues in Ubiquitin, Signal transduction, Salmonella enterica and Antigen presentation. His Vacuole, Phosphorylation and Protein tyrosine phosphatase study, which is part of a larger body of work in Cell biology, is frequently linked to STED microscopy, bridging the gap between disciplines.
His studies deal with areas such as Immune system, Salmonella, Bacteria, Intracellular and Virulence as well as Microbiology. His Virulence study integrates concerns from other disciplines, such as Dynein, Microtubule and Innate immune system. His Type three secretion system research includes themes of Formins, T cell, FADD, Pathogenicity island and Necroptosis.
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Simultaneous identification of bacterial virulence genes by negative selection
Michael Hensel;Jacqueline E. Shea;Colin Gleeson;Michael D. Jones.
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium
Jacqueline E. Shea;Michael Hensel;Colin Gleeson;David W. Holden.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages
Michael Hensel;Jacqueline E. Shea;Scott R. Waterman;Rosanna Mundy.
Molecular Microbiology (1998)
Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.
Andrés Vazquez-Torres;Yisheng Xu;Jessica Jones-Carson;David W. Holden.
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA.
Carmen R. Beuzón;Stéphane Méresse;Kate E. Unsworth;Javier Ruíz-Albert.
The EMBO Journal (2000)
Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters
Sophie Helaine;Angela M. Cheverton;Kathryn G. Watson;Laura M. Faure.
Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis
Ji-Min Mei;Fahimeh Nourbakhsh;Charles W. Ford;David W. Holden.
Molecular Microbiology (1997)
Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system.
Scott R Waterman;David W Holden.
Cellular Microbiology (2003)
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
Jeremy S. Brown;Tracy Hussell;Sarah M. Gilliland;David W. Holden.
Proceedings of the National Academy of Sciences of the United States of America (2002)
A functional genomic analysis of type 3 Streptococcus pneumoniae virulence.
Gee W. Lau;Sauli Haataja;Michael Lonetto;Sarah E. Kensit.
Molecular Microbiology (2001)
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