What is he best known for?
The fields of study he is best known for:
His primary areas of study are Microbiology, Virulence, Pathogenicity island, Type three secretion system and Mutant.
His Microbiology research incorporates themes from Salmonella, Bacteria, Intracellular, Lectin pathway and Complement membrane attack complex.
His Virulence study is concerned with Genetics in general.
His biological study spans a wide range of topics, including Streptococcus pneumoniae and Locus.
His biological study spans a wide range of topics, including Vacuole and Effector.
His Effector study also includes fields such as
- Intracellular parasite, Salmonella enterica, Cell biology and Cell division most often made with reference to Secretion,
- Locus of enterocyte effacement most often made with reference to Mutation.
His most cited work include:
- Simultaneous identification of bacterial virulence genes by negative selection (1186 citations)
- Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium (705 citations)
- Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages (542 citations)
What are the main themes of his work throughout his whole career to date?
David W. Holden spends much of his time researching Microbiology, Virulence, Type three secretion system, Cell biology and Effector.
His Microbiology research incorporates themes from Salmonella, Salmonella enterica, Pathogenicity island, Bacteria and Intracellular.
His research integrates issues of Mutagenesis, Mutant and Streptococcus pneumoniae in his study of Virulence.
His Type three secretion system research includes elements of Entry into host and Host cell cytosol, Vacuole, Cytosol.
His Cell biology research is multidisciplinary, incorporating elements of Actin cytoskeleton and Programmed cell death.
As part of the same scientific family, he usually focuses on Effector, concentrating on Secretion and intersecting with Innate immune system.
He most often published in these fields:
- Microbiology (62.73%)
- Virulence (36.36%)
- Type three secretion system (32.73%)
What were the highlights of his more recent work (between 2012-2021)?
- Effector (30.00%)
- Cell biology (30.00%)
- Microbiology (62.73%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Effector, Cell biology, Microbiology, Type three secretion system and Secretion.
The concepts of his Effector study are interwoven with issues in Ubiquitin, Signal transduction, Salmonella enterica and Antigen presentation.
His Vacuole, Phosphorylation and Protein tyrosine phosphatase study, which is part of a larger body of work in Cell biology, is frequently linked to STED microscopy, bridging the gap between disciplines.
His studies deal with areas such as Immune system, Salmonella, Bacteria, Intracellular and Virulence as well as Microbiology.
His Virulence study integrates concerns from other disciplines, such as Dynein, Microtubule and Innate immune system.
His Type three secretion system research includes themes of Formins, T cell, FADD, Pathogenicity island and Necroptosis.
Between 2012 and 2021, his most popular works were:
- Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters (405 citations)
- Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences. (134 citations)
- Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma (100 citations)
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