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Genetics

D-Index
47
Citations
12133
World Ranking
4098
National Ranking
149

Overview

Hein te Riele is affiliated with the Netherlands Cancer Institute in the Netherlands. Their research is focused on various aspects of molecular biology and cancer research, with primary contributions in biochemistry, genetics, and molecular biology as well as medicine.

The main fields of study related to their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields explored in their publications encompass:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Pathology and Forensic Medicine
  • Cancer Research

The scientific topics frequently addressed in their research involve:

  • DNA Repair Mechanisms
  • Cancer-related Molecular Pathways
  • Microtubule and mitosis dynamics
  • Genomics and Chromatin Dynamics
  • Genetic factors in colorectal cancer
  • CRISPR and Genetic Engineering
  • RNA Research and Splicing

Hein te Riele has published in a variety of scientific venues. Frequent publication outlets include:

  • Nucleic Acids Research
  • Cancer Discovery
  • Nature Communications
  • Developmental Cell
  • Genome Medicine

Their recent significant papers are:

  • Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion, 2020, Nature Communications
  • WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion, 2020, Developmental Cell
  • Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy, 2024, Cancer Discovery
  • Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer, 2021, Genome Medicine
  • The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity, 2021, Frontiers in Pharmacology

Frequent collaborators include:

  • Cor Lieftink
  • Roderick L. Beijersbergen
  • Frank van Gemert
  • Wietske Pieters
  • Jonne A. Raaijmakers

Best Publications

  • E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

    Gretchen Bain;Els C.Robanus Maandag;David J. Izon;Derk Amsen

  • Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

    Niels de Wind;Marleen Dekker;Anton Berns;Miroslav Radman

  • High efficiency gene targeting in mouse embryonic stem cells

    Anton Berns;Els Robanus Maandag;Hein te Riele

  • An HMG-box-containing T-cell factor required for thymocyte differentiation.

    Sjef Verbeek;David Izon;Frans Hofhuis;Els Robanus-Maandag

  • Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions.

    Jan-Hermen Dannenberg;Agnes van Rossum;Leontine Schuijff;Hein te Riele

  • p107 is a suppressor of retinoblastoma development in pRb-deficient mice

    Els Robanus-Maandag;Marleen Dekker;Martin van der Valk;Maria-Luisa Carrozza

  • Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch–repair proteins

    Walther J. A. A. van den Broek;Marcel R. Nelen;Derick G. Wansink;Marga M. Coerwinkel

  • E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

    Joseph B. Rayman;Yasuhiko Takahashi;Vahan B. Indjeian;Jan-Hermen Dannenberg

  • Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

    Jacob B. Hansen;Claus Jørgensen;Rasmus K. Petersen;Philip Hallenborg

  • Inducing and exploiting vulnerabilities for the treatment of liver cancer.

    Cun Wang;Cun Wang;Serena Vegna;Haojie Jin;Haojie Jin;Bente Benedict

  • Mismatch repair gene Msh2 modifies the timing of early disease in HdhQ111 striatum

    Vanessa C. Wheeler;Lori-Anne Lebel;Vladimir Vrbanac;Allison Teed

  • Both E12 and E47 Allow Commitment to the B Cell Lineage

    Gretchen Bain;Els C.Robanus Maandag;Hein P.J.te Riele;Ann J Feeney

  • CTG repeat instability and size variation timing in DNA repair-deficient mice

    Cédric Savouret;Edith Brisson;Jeroen Essers;Roland Kanaar

  • Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

    Tiziana Scanu;Robbert M. Spaapen;Jeroen M. Bakker;Chandra Bhan Pratap

  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.

    Theodore L. DeWeese;Jennifer M. Shipman;Nicole A. Larrier;Nicola M. Buckley

  • Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

    Neil J. Toft;Douglas J. Winton;Jane Kelly;Louise A. Howard

  • Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

    Jan-Hermen Dannenberg;Leontine Schuijff;Marleen Dekker;Martin van der Valk

  • Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.

    Laurent Foiry;Li Dong;Cédric Savouret;Laurence Hubert

  • Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells.

    Egle Balciunaite;Alexander Spektor;Nathan H. Lents;Hugh Cam

  • Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M

    Sietske T. Bakker;Henri J. van de Vrugt;Martin A. Rooimans;Anneke B. Oostra

Frequent Co-Authors

Anton Berns
Anton Berns Antoni van Leeuwenhoek Hospital
René H. Medema
René H. Medema Princess Máxima Center
Johan P. de Winter
Johan P. de Winter VU University Medical Center
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
Hans Joenje
Hans Joenje VU University Medical Center
Claudine Junien
Claudine Junien INRAE : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
Roderick L. Beijersbergen
Roderick L. Beijersbergen Antoni van Leeuwenhoek Hospital
Glenn E. Morris
Glenn E. Morris Keele University
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam

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