World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
62
Citations
17322
World Ranking
3106
National Ranking
1454

Overview

David A. Horwitz is affiliated with the University of Southern California in the United States. Their research primarily focuses on immunology and microbiology, with particular attention to subfields including immunology, surgery, pharmaceutical science, rheumatology, and endocrinology, diabetes, and metabolism.

The scientist's work covers multiple topics related to immune system functioning and disease treatment. Main topics include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Reproductive System and Pregnancy
  • Immunotherapy and Immune Responses
  • Pancreatic Function and Diabetes
  • Advanced Drug Delivery Systems
  • Systemic Lupus Erythematosus Research

David A. Horwitz has contributed extensively to the field through several recent publications. Some of the notable papers include:

  • "Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin," 2021, Nature Biomedical Engineering
  • "Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases," 2021, Frontiers in Immunology
  • "Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4+ and CD8+ Tregs That Are Functional in Humanized Mice," 2021, Frontiers in Immunology
  • "Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism," 2020, Frontiers in Immunology
  • "Nanoparticle-mediated delivery of IL-2 to T follicular helper cells protects BDF1 mice from lupus-like disease," 2021, Rheumatology and Immunology Research

These research contributions appear predominantly in venues such as:

  • Frontiers in Immunology
  • Nature Biomedical Engineering
  • Rheumatology and Immunology Research
  • Abstracts

Frequent collaborators with David A. Horwitz include:

  • Sean Bickerton
  • Antonio La Cava
  • Dongin Kim
  • Tarek M. Fahmy
  • Jung Seok Lee

The scientist's research encompasses advanced drug delivery systems, notably the use of nanoparticles to modulate immune responses and treat autoimmune diseases such as systemic lupus erythematosus (SLE) and type 1 diabetes. Their work addresses both fundamental immune cell interactions and translational approaches to therapy, combining insights from immunology, rheumatology, and metabolic disease domains.

Best Publications

  • Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial

    Larry W. Moreland;Michael H. Schiff;Scott W. Baumgartner;Elizabeth A. Tindall

  • A revised estimate of twin concordance in systemic lupus erythematosus

    Dennis Deapen;Agustin Escalante;Lisa Weinrib;David Horwitz

  • Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

    Song Guo Zheng;Ju Hua Wang;J. Dixon Gray;Harold Soucier

  • A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood.

    S Yamagiwa;J D Gray;S Hashimoto;D A Horwitz

  • IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

    Song Guo Zheng;Juhua Wang;Pu Wang;J. Dixon Gray

  • Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

    Song Guo Zheng;J. Dixon Gray;Kazuo Ohtsuka;Satoshi Yamagiwa

  • Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

    M Linker-Israeli;A C Bakke;R C Kitridou;S Gendler

  • TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells

    Song Guo Zheng;Ju Hua Wang;William Stohl;Kyoung Soo Kim

  • Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other

    David A. Horwitz;Song Guo Zheng;J. Dixon Gray

  • Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

    Song Guo Zheng;Juhua Wang;David A. Horwitz

  • DEPRESSED CELL-MEDIATED IMMUNITY IN PATIENTS WITH PRIMARY INTRACRANIAL TUMORS

    Unknown

  • Identification of Two Populations of Immunoglobulin-Bearing Lymphocytes in Man

    Peter I. Lobo;Frederic B. Westervelt;David A. Horwitz

  • Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus

    David A. Horwitz;J. Dixon Gray;Steven C. Behrendsen;Marek Kubin

  • The role of the combination of IL-2 and TGF-β or IL-10 in the generation and function of CD4+ CD25+ and CD8+regulatory T cell subsets

    David A. Horwitz;Song Guo Zheng;J. Dixon Gray

  • CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome

    Song Guo Zheng;Ju Hua Wang;Michael N. Koss;Francisco Quismorio

  • Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

    Xiaohui Zhou;Ning Kong;Ning Kong;Julie Wang;Huiming Fan

  • Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg

    David A. Horwitz;Song Guo Zheng;Juhua Wang;J. Dixon Gray

  • Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

    Ling Lu;Ling Lu;Qin Lan;Qin Lan;Zhiyuan Li;Xiaohui Zhou;Xiaohui Zhou

  • Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus.

    Ohtsuka K;Gray Jd;Stimmler Mm;Toro B

  • Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma.

    Xiu Hua Yang;Satoshi Yamagiwa;Takafumi Ichida;Yasunobu Matsuda

  • The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.

    J D Gray;M Hirokawa;D A Horwitz

  • Synergistic effect between IL‐10 and bcl‐2 genotypes in determining susceptibility to systemic lupus erythematosus

    Ruty Mehrian;Francisco P. Quismorio;Gideon Strassmann;Mary M. Stimmler

Frequent Co-Authors

Song Guo Zheng
Song Guo Zheng Shanghai Jiao Tong University
David D. Brand
David D. Brand University of Tennessee Health Science Center
Wei Shi
Wei Shi University of Southern California
Bernhard Ryffel
Bernhard Ryffel University of Orléans
William Stohl
William Stohl University of Southern California
Antonio La Cava
Antonio La Cava University of California, Los Angeles
Dennis Deapen
Dennis Deapen University of Southern California
Paul K. Pattengale
Paul K. Pattengale University of Southern California
Thomas M. Mack
Thomas M. Mack University of Southern California

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those studying Immunology in the USA, there are several complementary online degree options that can enhance your career prospects. Many students explore advanced nursing roles, which often overlap with immunological knowledge, especially in critical care settings.

Nurses interested in expanding their expertise may consider transitioning from family nurse practitioner (FNP) roles to more specialized fields. Resources on how to fnp to acute care np offer valuable guidance for this transition, combining immunology insights with acute patient care.

Accelerated pathways also exist for those seeking faster entry into advanced practice nursing. The best accelerated np program options provide intensive training that can complement immunology expertise with clinical skills.

For individuals without a nursing background, online programs designed specifically for non-nurses can be a practical first step. The most effective online absn programs for non nurses offer flexible routes into nursing careers, which can pave the way for future immunology-focused roles.

Finally, it's important to consider financial outcomes when choosing a career in health sciences. Exploring the dnp salary by state gives insights into potential earnings, helping guide decisions aligned with both your passion and practical needs.

Best Scientists Citing David A. Horwitz

Trending Scientists

Recently Published Articles