Her primary areas of study are Immunology, Immune system, Mycobacterium tuberculosis, Tuberculosis and Cytokine. Her Immunology study frequently draws connections to adjacent fields such as Treatment strategy. The study incorporates disciplines such as Cancer research and Effector in addition to Immune system.
Her studies deal with areas such as Tumor necrosis factor alpha, Granuloma and Immunity as well as Mycobacterium tuberculosis. Her biological study spans a wide range of topics, including Inflammation and Chemokine. Her T cell research is multidisciplinary, relying on both Andrology and Virology.
Denise E. Kirschner focuses on Immunology, Immune system, Tuberculosis, Mycobacterium tuberculosis and Granuloma. Her Virology research extends to the thematically linked field of Immunology. Immune system is often connected to Effector in her work.
Her Tuberculosis research is multidisciplinary, incorporating elements of Antibiotics, Computational biology, Systems biology, Disease and In silico. She combines subjects such as Pathogen, Inflammation, Interferon gamma, Granuloma formation and Interleukin 10 with her study of Mycobacterium tuberculosis. The T cell study combines topics in areas such as Lymph node and Priming, Antigen.
Her scientific interests lie mostly in Tuberculosis, Granuloma, Mycobacterium tuberculosis, Immunology and Immune system. The concepts of her Tuberculosis study are interwoven with issues in Pharmacokinetics, Clinical trial, Epidemiology and Computational biology, Systems biology. Her Immunology study combines topics in areas such as Antibiotics and Isoniazid.
Her research in Immune system intersects with topics in Myeloid, Myofibroblast, Lung and Cytokine. In her research, Bacterial cell structure is intimately related to T cell, which falls under the overarching field of Cytokine. Her Immunity research is multidisciplinary, incorporating perspectives in Proinflammatory cytokine, Inflammation, Inflammatory response and Interleukin 10.
Tuberculosis, Immunology, Immune system, Vaccination and Immunity are her primary areas of study. Her work deals with themes such as Clinical trial, Epidemiology, Environmental health, Mortality rate and Cause of death, which intersect with Tuberculosis. Denise E. Kirschner is interested in Granuloma, which is a branch of Immunology.
Her Immune system study integrates concerns from other disciplines, such as Cytokine and Mycobacterium tuberculosis. Her Cytokine research includes elements of T cell, Lung and Bacterial cell structure. Her studies in Immunity integrate themes in fields like Inflammation, Proinflammatory cytokine, Neuroscience and Interleukin 10.
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A methodology for performing global uncertainty and sensitivity analysis in systems biology
Simeone Marino;Ian B. Hogue;Christian J. Ray;Denise E. Kirschner.
Journal of Theoretical Biology (2008)
Dynamics of HIV infection of CD4+ T cells
Alan S. Perelson;Denise E. Kirschner;Rob De Boer.
Bellman Prize in Mathematical Biosciences (1993)
Modeling immunotherapy of the tumor-immune interaction.
Denise E. Kirschner;John Carl Panetta.
Journal of Mathematical Biology (1998)
Optimal control of the chemotherapy of HIV.
Denise Kirschner;Suzanne Lenhart;Steve Serbin.
Journal of Mathematical Biology (1997)
Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model.
Jose L. Segovia-Juarez;Suman Ganguli;Denise Kirschner.
Journal of Theoretical Biology (2004)
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
Joshua T. Mattila;Olabisi O. Ojo;Diane Kepka-Lenhart;Simeone Marino.
Journal of Immunology (2013)
Using Mathematics to Understand HIV Immune Dynamics
A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis
Janis E. Wigginton;Denise Kirschner.
Journal of Immunology (2001)
The equilibria that allow bacterial persistence in human hosts
Martin J. Blaser;Denise E. Kirschner.
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.
Hannah Priyadarshini Gideon;Jia Yao Phuah;Amy J. Myers;Bryan D. Bryson.
PLOS Pathogens (2015)
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