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Immunology

D-Index
68
Citations
18235
World Ranking
2574
National Ranking
1229

Overview

Denise E. Kirschner is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on infectious diseases, especially tuberculosis, as well as related fields such as epidemiology and molecular biology. Their work spans various interdisciplinary areas including biomedical engineering and modeling and simulation.

Their recent publications reflect a strong emphasis on systems biology, disease modeling, and immunology. Among notable papers are:

  • To Sobol or not to Sobol? The effects of sampling schemes in systems biology applications, 2021, Mathematical Biosciences
  • Predicting the second wave of COVID-19 in Washtenaw County, MI, 2020, Journal of Theoretical Biology
  • Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation, 2020, PLoS Computational Biology
  • Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination, 2021, Frontiers in Immunology
  • Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas, 2020, Frontiers in Pharmacology

Denise E. Kirschner has collaborated frequently with several researchers, including:

  • Jennifer J. Linderman
  • JoAnne L. Flynn
  • Maral Budak
  • Joshua T. Mattila
  • Pauline Maiello

Their publications appear regularly in various scientific journals and preprint servers, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Theoretical Biology
  • PLoS Computational Biology
  • Frontiers in Immunology
  • Frontiers in Pharmacology

Their main fields of study focus on medicine and biochemistry, genetics, and molecular biology. Subfields of their research include infectious diseases, epidemiology, molecular biology, modeling and simulation, and biomedical engineering.

The topics covered by their work include:

  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • COVID-19 epidemiological studies
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Vaccines and immunoinformatics approaches
  • Infectious Diseases and Tuberculosis
  • Data-Driven Disease Surveillance

Best Publications

  • Dynamics of HIV infection of CD4+ T cells

    Alan S. Perelson;Denise E. Kirschner;Rob De Boer

  • Modeling immunotherapy of the tumor-immune interaction.

    Denise E. Kirschner;John Carl Panetta

  • Optimal control of the chemotherapy of HIV.

    Denise Kirschner;Suzanne Lenhart;Steve Serbin

  • Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model.

    Jose L. Segovia-Juarez;Suman Ganguli;Denise Kirschner

  • Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

    Joshua T. Mattila;Olabisi O. Ojo;Diane Kepka-Lenhart;Simeone Marino

  • Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

    Hannah Priyadarshini Gideon;Jia Yao Phuah;Amy J. Myers;Bryan D. Bryson

  • Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.

    Joseph M. Cicchese;Stephanie Evans;Caitlin Hult;Louis R. Joslyn

  • A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis

    Janis E. Wigginton;Denise Kirschner

  • Using Mathematics to Understand HIV Immune Dynamics

    Denise Kirschner

  • A mathematical model of tumor-immune evasion and siRNA treatment

    J.C. Arciero;T.L. Jackson;D.E. Kirschner

  • A model for treatment strategy in the chemotherapy of aids

    Denise Kirschner;G. F. Webb

  • The human immune response to Mycobacterium tuberculosis in lung and lymph node.

    Simeone Marino;Denise E. Kirschner

  • Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

    Simeone Marino;Nicholas A. Cilfone;Joshua T. Mattila;Jennifer J. Linderman

  • Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation

    Mohammad Fallahi-Sichani;Mohammed El-Kebir;Mohammed El-Kebir;Simeone Marino;Denise E. Kirschner

  • Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection.

    Dhruv Sud;Carolyn Bigbee;JoAnne L. Flynn;Denise E. Kirschner

  • Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection

    J. Christian J. Ray;JoAnne L. Flynn;Denise E. Kirschner

  • Systems biology of persistent infection: tuberculosis as a case study.

    Douglas Young;Jaroslav Stark;Denise Kirschner

  • Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis.

    Simeone Marino;Santosh Pawar;Craig L. Fuller;Todd A. Reinhart

  • Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs.

    Soumya D. Chakravarty;Guofeng Zhu;Ming C. Tsai;Vellore P. Mohan

  • Dynamics of Co-infection with M. tuberculosis and HIV-1

    Denise E. Kirschner

  • Reevaluation of T Cell Receptor Excision Circles as a Measure of Human Recent Thymic Emigrants

    Ping Ye;Denise E. Kirschner

Frequent Co-Authors

Jennifer J. Linderman
Jennifer J. Linderman University of Michigan–Ann Arbor
JoAnne L. Flynn
JoAnne L. Flynn University of Pittsburgh
Glenn F. Webb
Glenn F. Webb Vanderbilt University
Philana Ling Lin
Philana Ling Lin University of Pittsburgh
Todd A. Reinhart
Todd A. Reinhart University of Pittsburgh
Mark J. Miller
Mark J. Miller Washington University in St. Louis
Véronique Dartois
Véronique Dartois Rutgers, The State University of New Jersey
Bethany B. Moore
Bethany B. Moore University of Michigan–Ann Arbor
John Chan
John Chan Albert Einstein College of Medicine
Martin J. Blaser
Martin J. Blaser Rutgers, The State University of New Jersey

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