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Biology and Biochemistry

D-Index
56
Citations
9226
World Ranking
14630
National Ranking
6124

Overview

Jennifer J. Linderman is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans several interconnected fields, primarily within Medicine and Biochemistry, Genetics and Molecular Biology. A significant portion of their work contributes to understanding infectious diseases, molecular biology, oncology, epidemiology, and imaging sciences such as radiology and nuclear medicine.

Their scientific investigations focus extensively on tuberculosis research and epidemiology, monoclonal and polyclonal antibodies research, and Mycobacterium research and diagnosis. Additional topics covered in their body of work include innovative microfluidic and catalytic techniques innovation, HER2/EGFR in cancer research, gene regulatory network analysis, and CAR-T cell therapy research.

Jennifer J. Linderman has authored multiple research papers published in notable scientific venues. Selected recent publications include:

  • "Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space," 2022, Nature Communications
  • "Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination," 2021, Frontiers in Immunology
  • "Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas," 2020, Frontiers in Pharmacology
  • "A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes," 2022, Journal of Theoretical Biology
  • "A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination," 2020, PLoS Computational Biology

Their frequent co-authors include Denise E. Kirschner, JoAnne L. Flynn, Gary D. Luker, Patrick C. Kinnunen, and Greg M. Thurber, reflecting collaborative research efforts predominantly within biomedical modeling and infectious disease domains.

Regarding publication venues, Jennifer J. Linderman has contributed multiple papers to outlets such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Journal of Theoretical Biology, PLoS Computational Biology, and Cellular and Molecular Bioengineering.

Best Publications

  • Receptors: Models for Binding, Trafficking, and Signaling

    Douglas A Lauffenburger;Jennifer J Linderman

  • Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.

    Joseph M. Cicchese;Stephanie Evans;Caitlin Hult;Louis R. Joslyn

  • Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture.

    Geeta Mehta;Khamir Mehta;Dhruv Sud;Jonathan W. Song

  • Nanoscale Adhesion Ligand Organization Regulates Osteoblast Proliferation and Differentiation.

    Kuen Yong Lee;Eben Alsberg;Susan Hsiong;Wendy Comisar

  • Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

    Simeone Marino;Nicholas A. Cilfone;Joshua T. Mattila;Jennifer J. Linderman

  • Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation

    Mohammad Fallahi-Sichani;Mohammed El-Kebir;Mohammed El-Kebir;Simeone Marino;Denise E. Kirschner

  • Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: a combined computational and experimental approach.

    Wendy A. Comisar;Nikolas H. Kazmers;David J. Mooney;Jennifer J. Linderman

  • A Spatial Focusing Model for G Protein Signals: REGULATOR OF G PROTEIN SIGNALING (RGS) PROTEIN-MEDIATED KINETIC SCAFFOLDING *

    Huailing Zhong;Susan M. Wade;Peter J. Woolf;Jennifer J. Linderman

  • Hard top soft bottom microfluidic devices for cell culture and chemical analysis.

    Geeta Mehta;Jay Lee;Wansik Cha;Yi Chung Tung

  • An Adaptive, Cartesian, Front-Tracking Method for the Motion, Deformation and Adhesion of Circulating Cells

    G. Agresar;J.J. Linderman;G. Tryggvason;K.G. Powell

  • Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection.

    Nicholas A. Cilfone;Cory R. Perry;Denise E. Kirschner;Jennifer J. Linderman

  • Optical imaging in microfluidic bioreactors enables oxygen monitoring for continuous cell culture

    Dhruv Sud;Geeta Mehta;Khamir Mehta;Jennifer Linderman

  • NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis.

    Mohammad Fallahi-Sichani;Denise E. Kirschner;Jennifer J. Linderman

  • Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability

    Mohammad Fallahi-Sichani;JoAnne L. Flynn;Jennifer J. Linderman;Denise E. Kirschner

  • Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages.

    Stewart T. Chang;Jennifer J. Linderman;Denise E. Kirschner

  • Push-pull perfusion sampling with segmented flow for high temporal and spatial resolution in vivo chemical monitoring.

    Thomas R. Slaney;Jing Nie;Neil D. Hershey;Prasanna K. Thwar

  • Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study

    Mohammad Fallahi-Sichani;Jennifer J. Linderman

  • Strategies for Efficient Numerical Implementation of Hybrid Multi-scale Agent-Based Models to Describe Biological Systems

    Nicholas A. Cilfone;Denise E. Kirschner;Jennifer J. Linderman

  • Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling

    Tamara L Kinzer-Ursem;Jennifer J Linderman

  • Microtubule assembly is regulated by externally applied strain in cultured smooth muscle cells

    Andrew J. Putnam;James J. Cunningham;Robert G. Dennis;Jennifer J. Linderman

Frequent Co-Authors

Denise E. Kirschner
Denise E. Kirschner University of Michigan–Ann Arbor
Shuichi Takayama
Shuichi Takayama Georgia Institute of Technology
JoAnne L. Flynn
JoAnne L. Flynn University of Pittsburgh
Gary D. Luker
Gary D. Luker University of Michigan–Ann Arbor
David J. Mooney
David J. Mooney Harvard University
Richard R. Neubig
Richard R. Neubig Michigan State University
Mark J. Miller
Mark J. Miller Washington University in St. Louis
Véronique Dartois
Véronique Dartois Rutgers, The State University of New Jersey
Lonnie D. Shea
Lonnie D. Shea University of Michigan–Ann Arbor

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