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Neuroscience

D-Index
49
Citations
12151
World Ranking
5898
National Ranking
481

Overview

Wendy Noble is affiliated with King's College London in the United Kingdom. Their research primarily spans the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with focused contributions in subfields such as Physiology, Neurology, Molecular Biology, Cellular and Molecular Neuroscience, and Epidemiology.

The main topics addressed in their work include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Parkinson's Disease Mechanisms and Treatments
  • Mitochondrial Function and Pathology

Wendy Noble has authored several notable recent papers, which include:

  • Astrocytes in Tauopathies, published in 2020 in Frontiers in Neurology
  • Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain, published in 2020 in Neurobiology of Disease
  • Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2, published in 2020 in Redox Biology
  • Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia, published in 2022 in Aging Cell
  • Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection, published in 2024 in Science Advances

The researcher has frequently published in venues such as:

  • Alzheimer's & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cell and Developmental Biology
  • Brain Communications
  • Journal of Neurochemistry

Collaborations have involved several recurring co-authors, including:

  • Beatriz Gomez Perez-Nievas
  • Diane P. Hanger
  • Claire Troakes
  • María Jiménez-Sánchez
  • Saskia J. Pollack

Best Publications

  • Tau phosphorylation: the therapeutic challenge for neurodegenerative disease.

    Diane P. Hanger;Brian H. Anderton;Wendy Noble

  • Roles of tau protein in health and disease.

    Tong Guo;Wendy Jane Noble;Diane Pamela Hanger

  • Physiological release of endogenous tau is stimulated by neuronal activity.

    Amy M Pooler;Emma C Phillips;Dawn H W Lau;Wendy Noble

  • Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

    Wendy Noble;Vicki Olm;Kazuyuki Takata;Evelyn Casey

  • The importance of tau phosphorylation for neurodegenerative diseases.

    Wendy Noble;Diane P. Hanger;Christopher C. J. Miller;Simon Lovestone

  • Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

    Claire Garwood;Amy Pooler;J. Atherton;Diane Hanger

  • α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca 2+ homeostasis and mitochondrial ATP production

    Sébastien Paillusson;Patricia Gomez-Suaga;Radu Stoica;Daniel Little

  • Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

    Richard Killick;E M Ribe;R Al-Shawi;Bilal Malik

  • A role for tau at the synapse in Alzheimer's disease pathogenesis.

    Amy M Pooler;Wendy Noble;Diane P Hanger

  • Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

    Pascal Derkinderen;Timothy M. E. Scales;Diane P. Hanger;Kit-Yi Leung

  • Tau phosphorylation affects its axonal transport and degradation

    Teresa Rodríguez-Martín;Inmaculada Cuchillo-Ibáñez;Wendy Noble;Fanon Nyenya

  • Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production In Vivo

    Mark Burns;Kate Gaynor;Vicki Olm;Marc Mercken

  • Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression

    Adam R. Cole;Wendy Noble;Lidy Van Aalten;Florian Plattner

  • Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial.

    Robert Howard;Olga Zubko;Rosie Bradley;Emma Harper

  • Dynamic association of tau with neuronal membranes is regulated by phosphorylation.

    Amy M. Pooler;Alessia Usardi;Catherine J. Evans;Karen L. Philpott

  • Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

    Alessio Vagnoni;Michael S. Perkinton;Emma H. Gray;Paul T. Francis

  • Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease

    Wendy Noble;Claire Garwood;John Stephenson;Anna M. Kinsey

  • Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques

    Mark P Burns;Wendy J Noble;Vicki Olm;Kate Gaynor

  • Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

    Fiona Kerr;Oyinkan Sofola-Adesakin;Dobril K. Ivanov;Jemma Gatliff

  • The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

    Patricia Gómez-Suaga;Beatriz G. Pérez-Nievas;Elizabeth B. Glennon;Dawn H. W. Lau

  • Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain

    Ksenia Kurbatskaya;Emma Claire Phillips;Cara Louise Croft;Giacomo Dentoni

Frequent Co-Authors

Karen Duff
Karen Duff University College London
Michel Neunlist
Michel Neunlist University of Nantes
Karl Peter Giese
Karl Peter Giese King's College London
John T. O'Brien
John T. O'Brien University of Cambridge
Michael J. O'Neill
Michael J. O'Neill Eli Lilly (United States)
Alistair Burns
Alistair Burns University of Manchester
Linda Partridge
Linda Partridge Max Planck Society
Tara L. Spires-Jones
Tara L. Spires-Jones University of Edinburgh
Rory Johnson
Rory Johnson University College Dublin
Christopher Shaw
Christopher Shaw King's College London

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