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Immunology

D-Index
60
Citations
12914
World Ranking
3329
National Ranking
1544

Overview

Todd M. Brusko is affiliated with the University of Florida in the United States. Their research primarily spans across several main fields, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these broader areas, their work focuses on key subfields such as Immunology, Genetics, Surgery, Endocrinology, Diabetes and Metabolism, and Molecular Biology.

The topics of study that define their research include diabetes and associated disorders, immune cell function and interaction, pancreatic function and diabetes, T-cell and B-cell immunology, diabetes management and research, single-cell and spatial transcriptomics, and CAR-T cell therapy research.

Some of the recent notable papers authored or co-authored by Todd M. Brusko include:

  • "SARS-CoV-2 infection generates tissue-localized immunological memory in humans" (2021) published in Science Immunology
  • "The immunology of type 1 diabetes" (2024) in Nature Reviews Immunology
  • "Strategies for durable β cell replacement in type 1 diabetes" (2021) in Science
  • "Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness" (2021) in Journal of Clinical Medicine
  • "Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood" (2023) in Immunity

Frequent co-authors associated with their work include Mark A. Atkinson, Maigan A. Brusko, Amanda L. Posgai, Clive Wasserfall, and Melanie R. Shapiro.

Their research has been published consistently in specific scientific venues with repeated contributions to bioRxiv (Cold Spring Harbor Laboratory), Diabetes, Frontiers in Immunology, The Journal of Immunology, and Diabetologia.

Best Publications

  • Normalization of CD4+ T cell metabolism reverses lupus

    Yiming Yin;Seung Chul Choi;Zhiwei Xu;Daniel J. Perry

  • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

    Christopher E Lowe;Jason D Cooper;Todd Brusko;Neil M Walker

  • Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

    Stephanie A. McClymont;Amy L. Putnam;Michael R. Lee;Jonathan H. Esensten

  • Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.

    Matthias H. Kapturczak;Clive Wasserfall;Todd Brusko;Martha Campbell-Thompson

  • Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes

    Todd M. Brusko;Clive H. Wasserfall;Michael J. Clare-Salzler;Desmond A. Schatz

  • Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.

    Todd M. Brusko;Amy L. Putnam;Jeffrey A. Bluestone

  • Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

    Amy L. Putnam;Todd M. Brusko;Michael R. Lee;Weihong Liu

  • Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

    Manuela Battaglia;Simi Ahmed;Mark S. Anderson;Mark A. Atkinson

  • No Alterations in the Frequency of FOXP3 + Regulatory T-Cells in Type 1 Diabetes

    Todd Brusko;Clive Wasserfall;Kieran McGrail;Richard Schatz

  • Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

    Christopher A. Fuhrman;Wen-I Yeh;Howard R. Seay;Priya Saikumar Lakshmi

  • Autologous Umbilical Cord Blood Infusion for Type 1 Diabetes

    Michael J. Haller;Hilla-Lee Viener;Clive Wasserfall;Todd Brusko

  • SARS-CoV-2 infection generates tissue-localized immunological memory in humans.

    Maya M.L. Poon;Ksenia Rybkina;Yu Kato;Masaru Kubota

  • Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion

    Kevin S. Goudy;Brant R. Burkhardt;Clive Wasserfall;Sihong Song

  • Human Treg responses allow sustained recombinant adeno-associated virus- mediated transgene expression

    Christian Mueller;Jeffrey D. Chulay;Bruce C. Trapnell;Margaret Humphries

  • Central role for interleukin-2 in type 1 diabetes.

    Maigan A. Hulme;Clive H. Wasserfall;Mark A. Atkinson;Todd M. Brusko

  • An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4+CD25+ Regulatory T Cells

    Todd M. Brusko;Clive H. Wasserfall;Anupam Agarwal;Matthias H. Kapturczak

  • Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

    Todd M. Brusko;Richard C. Koya;Shirley Zhu;Michael R. Lee

  • Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis

    Philip O. Scumpia;Matthew J. Delano;Kindra M. Kelly;Kerri A. O’Malley

  • Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.

    Seung-Chul Choi;Anton A. Titov;Georges Abboud;Howard R. Seay

  • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells.

    Tatiana N. Golovina;Tatiana Mikheeva;Todd M. Brusko;Bruce R. Blazar

  • Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice

    Y. Clare Zhang;Antonello Pileggi;Anupam Agarwal;R. Damaris Molano

  • Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.

    James F. George;Andrea Braun;Todd M. Brusko;Reny Joseph

Frequent Co-Authors

Mark A. Atkinson
Mark A. Atkinson University of Florida
Clive Wasserfall
Clive Wasserfall University of Florida
Desmond A. Schatz
Desmond A. Schatz University of Florida
Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Martha Campbell-Thompson
Martha Campbell-Thompson University of Florida
Laurence Morel
Laurence Morel The University of Texas Health Science Center at San Antonio
Michael J. Clare-Salzler
Michael J. Clare-Salzler University of Florida
Lyle L. Moldawer
Lyle L. Moldawer University of Florida
Jonathan J. Shuster
Jonathan J. Shuster University of Florida
Chen Liu
Chen Liu Yale University

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