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Nicholas H. G. Holford

Nicholas H. G. Holford

D-Index & Metrics

Medicine

D-Index
77
Citations
21254
World Ranking
18449
National Ranking
40

Overview

Nicholas H. G. Holford is affiliated with the University of Auckland in New Zealand. Their research primarily focuses on Medicine, with notable contributions across multiple subfields including Pediatrics, Perinatology and Child Health, Pharmacology, Public Health, Environmental and Occupational Health, Pulmonary and Respiratory Medicine, and Economics and Econometrics.

Their recent research publications cover various topics in clinical pharmacology and pharmacometrics. Noteworthy papers include:

  • TDM is dead. Long live TCI!, 2020, British Journal of Clinical Pharmacology
  • Covariate modeling in pharmacometrics: General points for consideration, 2024, CPT Pharmacometrics & Systems Pharmacology
  • Consistent methods for fat-free mass, creatinine clearance, and glomerular filtration rate to describe renal function from neonates to adults, 2023, CPT Pharmacometrics & Systems Pharmacology
  • Wide size dispersion and use of body composition and maturation improves the reliability of allometric exponent estimates, 2021, Journal of Pharmacokinetics and Pharmacodynamics
  • A physiological approach to renal clearance: From premature neonates to adults, 2023, British Journal of Clinical Pharmacology

The scientist's frequent co-authors include:

  • David Metz
  • Conor J. O'Hanlon
  • Jacqueline A. Hannam
  • Jennett Kelsall
  • Giles Cunnick

Common publication venues for their research are:

  • European Journal of Surgical Oncology
  • British Journal of Clinical Pharmacology
  • CPT Pharmacometrics & Systems Pharmacology
  • Journal of Pharmacokinetics and Pharmacodynamics
  • International Journal of Molecular Sciences

The main topics covered in their work include:

  • Antibiotics Pharmacokinetics and Efficacy
  • Health Systems, Economic Evaluations, Quality of Life
  • Renal Transplantation Outcomes and Treatments
  • Pharmacogenetics and Drug Metabolism
  • Statistical Methods in Clinical Trials
  • Electrolyte and hormonal disorders
  • Neonatal Respiratory Health Research

Best Publications

  • Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models.

    Nicholas H. G. Holford;Lewis B. Sheiner

  • Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics

    Brian Anderson;Nicholas Holford

  • Kinetics of pharmacologic response.

    Nicholas H.G. Holford;Lewis B. Sheiner

  • A Size Standard for Pharmacokinetics

    Nicholas H. G. Holford

  • Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

    Brian J. Anderson;Nick H.G. Holford

  • A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models

    John Parke;Nicholas H.G. Holford;Bruce G. Charles

  • Human renal function maturation: a quantitative description using weight and postmenstrual age

    Malin M. Rhodin;Brian J. Anderson;Brian J. Anderson;A. Michael Peters;Malcolm G. Coulthard

  • Clinical Pharmacokinetics and Pharmacodynamics of Warfarin. Understanding the Dose-Effect Relationship

    Nicholas H. G. Holford

  • The response to levodopa in Parkinson's disease: imposing pharmacological law and order.

    John G. Nutt;Nicholas H. G. Holford

  • A pharmacokinetic standard for babies and adults

    Nick Holford;Young-A Heo;Brian Anderson

  • Simulation of clinical trials.

    N. H. G. Holford;H. C. Kimko;J. P. R. Monteleone;C. C. Peck

  • Clinical pharmacokinetics of ethanol

    Nicholas H. G. Holford

  • Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics.

    T. H. T. Nguyen;M-S Mouksassi;N. Holford;N. Al-Huniti

  • Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

    Nancy Bouwmeester;Brian Anderson;Dick Tibboel;N.H. Holford

  • Acetaminophen Developmental Pharmacokinetics in Premature Neonates and Infants: A Pooled Population Analysis

    Brian J. Anderson;Richard A. van Lingen;Tom G. Hansen;Yuan-Chi Lin

  • Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics.

    Daniel J. DeAngelo;Richard M. Stone;Mark L. Heaney;Stephen D. Nimer

  • Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

    Brian J. Anderson;Andrew D. McKee;Nicholas H. G. Holford

  • The Visual Predictive Check Superiority to Standard Diagnostic (Rorschach) Plots

    Nick Holford

  • Perioperative Pharmacodynamics of Acetaminophen Analgesia in Children

    Brian J. Anderson;Nicholas H. G. Holford;Gerald A. Woollard;Suchitra Kanagasundaram

  • Clinical Trial Simulation: A Review

    N Holford;S C Ma;B A Ploeger

Frequent Co-Authors

John G. Nutt
John G. Nutt Oregon Health & Science University
Leslie Z. Benet
Leslie Z. Benet University of California, San Francisco
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Dick Tibboel
Dick Tibboel Erasmus University Rotterdam
Jürgen B. Bulitta
Jürgen B. Bulitta St. Jude Children's Research Hospital
Wolfgang Sadee
Wolfgang Sadee The Ohio State University
William R. Wilson
William R. Wilson University of Auckland
Salim S. Abdool Karim
Salim S. Abdool Karim Centre for the AIDS Programme of Research in South Africa
Claire E. Wainwright
Claire E. Wainwright University of Queensland
Keith Grimwood
Keith Grimwood Griffith University

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