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MacDonald J. Christie

MacDonald J. Christie

D-Index & Metrics

Medicine

D-Index
85
Citations
26569
World Ranking
14609
National Ranking
481

Overview

MacDonald J. Christie is affiliated with the University of Sydney in Australia. Their research primarily spans several interconnected fields, including Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Within these broad areas, their focus narrows to Molecular Biology, Cellular and Molecular Neuroscience, and Physiology, with additional work related to Endocrinology, Diabetes and Metabolism, and Animal Science and Zoology.

The scientist's work revolves around topics such as Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling, Pharmacological Receptor Mechanisms and Effects, Pain Mechanisms and Treatments, Neuroscience and Neuropharmacology Research, Ion Channel Regulation and Function, and Diabetes Treatment and Management.

Their recent publications include:

  • Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists, 2020, Science Signaling
  • Morphine-induced respiratory depression is independent of β-arrestin2 signalling, 2020, British Journal of Pharmacology
  • Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia, 2021, Nature
  • Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor, 2020, Trends in Pharmacological Sciences
  • Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window, 2020, Molecular Pharmacology

Christie frequently collaborates with several co-authors, including:

  • Alexander Gillis (6 publications)
  • Stefan Schulz (6 publications)
  • Eamonn Kelly (5 publications)
  • Graeme Henderson (5 publications)
  • Mark Connor (4 publications)

Their research appears consistently in several publication venues. The most frequent venues include the IUPHAR/BPS Guide to Pharmacology, Frontiers in Pharmacology, Science Signaling, British Journal of Pharmacology, and Nature.

Best Publications

  • Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

    Lars M. Ittner;Yazi D. Ke;Fabien Delerue;Mian Bi

  • Cloning and expression of a rat D2 dopamine receptor cDNA.

    James R. Bunzow;Hubert H. M. Van Tol;David K. Grandy;Paul Albert

  • Cellular and synaptic adaptations mediating opioid dependence.

    John T. Williams;MacDonald J. Christie;Olivier Manzoni

  • Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

    John T. Williams;Susan L. Ingram;Graeme Henderson;Charles Chavkin

  • Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

    R A North;J T Williams;A Surprenant;M J Christie

  • Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

    Jeanne Tie;I. Kinde;Y. Wang;H. L. Wong

  • How opioids inhibit GABA-mediated neurotransmission

    C. W. Vaughan;S. L. Ingram;M. A. Connor;M. J. Christie

  • Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

    M J Christie

  • Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA.

    M.J. Christie;R.J. Summers;J.A. Stephenson;C.J. Cook

  • Conus Venom Peptide Pharmacology

    Richard J. Lewis;Sébastien Dutertre;Irina Vetter;MacDonald J. Christie

  • Opioid receptor signalling mechanisms.

    Mark Connor;MacDonald J Christie

  • Cellular mechanisms of opioid tolerance: studies in single brain neurons.

    M J Christie;J T Williams;R A North

  • Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits.

    M.J. Christie;R.A. North;P.B. Osborne;J. Douglass

  • Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human

    Michael M Morgan;MacDonald J Christie

  • Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro.

    Christopher W. Vaughan;Mark Connor;Elena E. Bagley;MacDonald J. Christie

  • Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.

    M.J. Christie;S. Bridge;L.B. James;P.M. Beart

  • Gingerols: a novel class of vanilloid receptor (VR1) agonists

    Vadim N Dedov;Van H Tran;Colin C Duke;Mark Connor

  • Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.

    Alexander Gillis;Arisbel B. Gondin;Andrea Kliewer;Julie Sanchez;Julie Sanchez

  • Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats

    MJ Christie;JT Williams;RA North

  • Increase by the ORL1 receptor (opioid receptor‐like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

    Christopher W. Vaughan;MacDonald J. Christie

Frequent Co-Authors

Christopher W. Vaughan
Christopher W. Vaughan University of Sydney
Paul F. Alewood
Paul F. Alewood University of Queensland
Richard J. Lewis
Richard J. Lewis University of Queensland
Michael Kassiou
Michael Kassiou University of Sydney
Philip M. Beart
Philip M. Beart Florey Institute of Neuroscience and Mental Health
David J. Adams
David J. Adams Wellcome Sanger Institute
Glenn F. King
Glenn F. King University of Queensland
Paul M. Pilowsky
Paul M. Pilowsky University of Sydney
R. A. North
R. A. North University of Manchester
Meritxell Canals
Meritxell Canals University of Nottingham

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