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Biology and Biochemistry

D-Index
66
Citations
14220
World Ranking
8741
National Ranking
223

Overview

Philip M. Beart is affiliated with the Florey Institute of Neuroscience and Mental Health in Australia. Their research spans critical areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on neurology and molecular biology subfields.

The scientist's work addresses topics including:

  • Medicinal Plants and Neuroprotection
  • Autophagy in Disease and Therapy
  • Amyotrophic Lateral Sclerosis Research
  • Medicinal Plants and Bioactive Compounds
  • Amino Acid Enzymes and Metabolism
  • Metabolism and Genetic Disorders
  • Glycogen Storage Diseases and Myoclonus

Philip M. Beart has contributed extensively to publications in several venues, with multiple papers published in journals such as:

  • Journal of Neurochemistry
  • British Journal of Pharmacology
  • Neurochemical Research
  • Neurochemistry International
  • IUPHAR/BPS Guide to Pharmacology CITE

Some notable recent papers include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Transporters, 2023, British Journal of Pharmacology
  • Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases, 2020, Journal of Neurochemistry
  • Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting, 2020, Cells
  • Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS, 2020, Neurochemical Research

Frequent collaborators in their research include:

  • S P H Alexander
  • Eamonn Kelly
  • Alistair Mathie
  • John A. Peters
  • Emma L. Veale

The scientist's research portfolio reveals a sustained focus on understanding mechanisms of neurodegeneration, autophagy, and metabolic pathways related to neurological diseases, particularly Amyotrophic Lateral Sclerosis. Their contributions are reflected across both experimental investigations and extensive reviews in pharmacology and neurochemistry.

Best Publications

  • Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

    Judy Bettina De Haan;Cecile Bladier;Peter Griffiths;Michael J Kelner

  • Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA.

    M.J. Christie;R.J. Summers;J.A. Stephenson;C.J. Cook

  • Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.

    P M Beart;R D O'Shea

  • Induction of the Unfolded Protein Response in Familial Amyotrophic Lateral Sclerosis and Association of Protein-disulfide Isomerase with Superoxide Dismutase 1

    Julie D. Atkin;Manal A. Farg;Bradley J. Turner;Doris Tomas

  • Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures.

    Linda D Mercer;Linda D Mercer;Belinda Louise Kelly;Belinda Louise Kelly;Malcolm Kenneth Horne;Malcolm Kenneth Horne;Philip M Beart;Philip M Beart

  • Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

    Daniel Offen;Philip M. Beart;Nam S. Cheung;Catherine J. Pascoe

  • Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.

    M.J. Christie;S. Bridge;L.B. James;P.M. Beart

  • Walking the tightrope: proteostasis and neurodegenerative disease.

    Justin J. Yerbury;Justin J. Yerbury;Lezanne Ooi;Lezanne Ooi;Andrew Dillin;Andrew Dillin;Darren N. Saunders;Darren N. Saunders

  • Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation.

    G. A. R. Johnston;D. R. Curtis;P. M. Beart;C. J. A. Game

  • Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones.

    Nam S Cheung;Catherine J Pascoe;Sarah F Giardina;Christopher A John

  • BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.

    Fiona Y. Carroll;Andreas Stolle;Philip M. Beart;Arnd Voerste

  • Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury.

    Gavin Clive Higgins;Philip M Beart;Yea Seul Shin;Minghui Jessica Chen

  • An excitant amino acid projection from the medial prefrontal cortex to the anterior part of nucleus accumbens in the rat

    M. J. Christie;L. B. James;P. M. Beart

  • Bicuculline methochloride as a GABA antagonist.

    G. A. R. Johnston;P. M. Beart;D. R. Curtis;C. J. A. Game

  • LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.

    Fiona Bonello;Sidi-Mohamed Hassoun;François Mouton-Liger;Yea Seul Shin

  • Excitant amino acid projections from rat amygdala and thalamus to nucleus accumbens.

    Timothy G. Robinson;Philip M. Beart

  • Medial prefrontal cortical lesions modulate baroreflex sensitivity in the rat.

    Anthony J.M. Verberne;Stephen J. Lewis;Peter J. Worland;Philip M. Beart

  • The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats

    Jian-Hui Liang;Feng Chen;Elena Krstew;Michael S. Cowen

  • Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats

    J.D. Salamone;P.M. Beart;J.E. Alpert;S.D. Iversen

  • Multifaceted deaths orchestrated by mitochondria in neurones.

    Phillip Nagley;Gavin Clive Higgins;Julie D Atkin;Philip M Beart

Frequent Co-Authors

Andrew J. Lawrence
Andrew J. Lawrence Florey Institute of Neuroscience and Mental Health
Phillip Nagley
Phillip Nagley Monash University
Andrew L. Gundlach
Andrew L. Gundlach Florey Institute of Neuroscience and Mental Health
Malcolm K. Horne
Malcolm K. Horne Florey Institute of Neuroscience and Mental Health
MacDonald J. Christie
MacDonald J. Christie University of Sydney
Graham A.R. Johnston
Graham A.R. Johnston University of Sydney
Roger J. Summers
Roger J. Summers Monash University
Ora Bernard
Ora Bernard St Vincents Institute of Medical Research
David Finkelstein
David Finkelstein St. Jude Children's Research Hospital
Julie D. Atkin
Julie D. Atkin Macquarie University

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