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Overview

Kathleen Claes is affiliated with Ghent University Hospital in Belgium and focuses on research in biochemistry, genetics, molecular biology, and medicine. Their work includes significant contributions in genetics, molecular biology, cancer research, pathology and forensic medicine, and oncology. The scientist's main areas of research interest encompass BRCA gene mutations in cancer, cancer genomics and diagnostics, genetic factors in colorectal cancer, genetic associations and epidemiology, ovarian cancer diagnosis and treatment, genomics and rare diseases, and DNA repair mechanisms.

Recent publications by Kathleen Claes include:

  • Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses, 2020, Nature Genetics
  • Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes, 2020, Nature Genetics
  • Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants, 2020, Genetics in Medicine
  • Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer, 2021, Scientific Reports
  • Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome, 2020, European Journal of Human Genetics

Kathleen Claes frequently publishes in the following venues:

  • European Journal of Human Genetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Cancers
  • The Journal of Experimental Medicine

The scientist's frequent co-authors include Irene L. Andrulis, Maria A. Caligo, D. Gareth Evans, Daniel Barrowdale, and Christoph Engel. Collaborative research with these colleagues is reflected in multiple publications.

Within the scope of their research, Kathleen Claes addresses numerous topics related to cancer genetics, including the identification of susceptibility loci for breast cancer, risk assessment for BRCA variant carriers, and cancer surveillance guidelines. Their interdisciplinary approach integrates genomic data, diagnostic methods, and epidemiological analysis to explore genetic contributions to cancer risk and mechanisms of DNA repair.

Best Publications

  • Breast-Cancer Risk in Families with Mutations in PALB2

    A. C. Antoniou;S. Casadei;T. Heikkinen;D. Barrowdale

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study

    Pieter Evenepoel;Kathleen Claes;Dirk Kuypers;Bart Maes

  • p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

    Björn K.I. Meijers;Kathleen Claes;Bert Bammens;Henriette de Loor

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

    Haoyu Zhang;Haoyu Zhang;Thomas U. Ahearn;Julie Lecarpentier;Daniel Barnes

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families

    Xin Yang;Goska Leslie;Alicja Doroszuk;Sandra Schneider

  • Fluid status in peritoneal dialysis patients: the European Body Composition Monitoring (EuroBCM) study cohort.

    Wim Van Biesen;John D. Williams;Adrian C. Covic;Stanley Fan

  • Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

    Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Lesley McGuffog;Daniel Barrowdale;Andrew Lee

  • Mycophenolate mofetil in IgA nephropathy: results of a 3-year prospective placebo-controlled randomized study.

    Bart D. Maes;Raymond Oyen;Kathleen Claes;Pieter Evenepoel

  • Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study

    Sabine Tejpar;Hubert Piessevaux;Kathleen Claes;Patricia Piront

  • Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

    Timothy R. Rebbeck;Tara M. Friebel;Eitan Friedman;Ute Hamann

  • Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk.

    Kim De Ruyck;Marcin Szaumkessel;Isabelle De Rudder;Annelore Dehoorne

  • Guidelines for the Li–Fraumeni and heritable TP53-related cancer syndromes

    Thierry Frebourg;Svetlana Bajalica Lagercrantz;Carla Oliveira;Rita Magenheim

  • Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

    Antonis C. Antoniou;Jonathan Beesley;Lesley McGuffog;Olga M. Sinilnikova

  • Clinical Efficacy and Toxicity Profile of Tacrolimus and Mycophenolic Acid in Relation to Combined Long-term Pharmacokinetics in de Novo Renal Allograft Recipients

    Dirk R. J. Kuypers;Kathleen Claes;Pieter Evenepoel;Bart Maes

  • Intrarenal resistive index after renal transplantation

    Maarten Naesens;Line Heylen;Evelyne Lerut;Kathleen Claes

  • Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD

    Ruben Poesen;Kathleen Claes;Pieter Evenepoel;Henriette de Loor

Frequent Co-Authors

Dirk Kuypers
Dirk Kuypers KU Leuven
Bruce Poppe
Bruce Poppe Ghent University Hospital
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Eitan Friedman
Eitan Friedman City University of New York
Melissa C. Southey
Melissa C. Southey Monash University
Anna Jakubowska
Anna Jakubowska Pomeranian Medical University

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