World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
33604
World Ranking
14129
National Ranking
252

Overview

Bruce Poppe is affiliated with Ghent University Hospital in Belgium, focusing primarily on research across the fields of medicine, biochemistry, genetics, and molecular biology. Their work encompasses genetics, molecular biology, oncology, physiology, and neurology with a particular emphasis on genetic factors and molecular mechanisms related to cancer and rare diseases.

Their recent publications highlight contributions to diagnostic criteria, cancer surveillance, and rare disease programs. Significant papers include:

  • Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation, 2021, Genetics in Medicine
  • Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation, 2022, Genetics in Medicine
  • Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome, 2020, European Journal of Human Genetics
  • Shortcutting the diagnostic odyssey: the multidisciplinary Program for Undiagnosed Rare Diseases in adults (UD-PrOZA), 2022, Orphanet Journal of Rare Diseases
  • Mutations in RNU7-1 Weaken Secondary RNA Structure, Induce MCP-1 and CXCL10 in CSF, and Result in Aicardi-Goutières Syndrome with Severe End-Organ Involvement, 2022, Journal of Clinical Immunology

Frequent coauthors collaborating with Bruce Poppe include Dimitri Hemelsoet, Wim Terryn, Thierry Frébourg, D. Gareth Evans, and Nicoline Hoogerbrugge.

Their research is regularly published in journals such as:

  • Genetics in Medicine
  • European Journal of Human Genetics
  • European Journal of Cancer Prevention
  • Orphanet Journal of Rare Diseases
  • Journal of Clinical Immunology

Main topics addressed in Bruce Poppe's work cover areas including:

  • BRCA gene mutations in cancer
  • Genomics and Rare Diseases
  • Neurofibromatosis and Schwannoma Cases
  • Cytokine Signaling Pathways and Interactions
  • Peroxisome Proliferator-Activated Receptors
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics

This profile reflects the scientist's multidisciplinary engagement with genetics and molecular biology as applied to oncology and rare diseases, with a sustained focus on translating genomic and diagnostic research into clinical contexts.

Best Publications

  • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

    Jo Vandesompele;Katleen De Preter;Filip Pattyn;Bruce Poppe

  • Breast-Cancer Risk in Families with Mutations in PALB2

    A. C. Antoniou;S. Casadei;T. Heikkinen;D. Barrowdale

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • PHF6 mutations in T-cell acute lymphoblastic leukemia

    Pieter van Vlierberghe;Pieter van Vlierberghe;Pieter van Vlierberghe;Teresa Palomero;Hossein Khiabanian;Joni van der Meulen

  • Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

    Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Lesley McGuffog;Daniel Barrowdale;Andrew Lee

  • ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

    Sofie Peirs;Filip Matthijssens;Steven Goossens;Inge Van de Walle

  • ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.

    Pascale De Paepe;Mathijs Baens;Mathijs Baens;Han van Krieken;Han van Krieken;Bruno Verhasselt;Bruno Verhasselt

  • Guidelines for the Li–Fraumeni and heritable TP53-related cancer syndromes

    Thierry Frebourg;Svetlana Bajalica Lagercrantz;Carla Oliveira;Rita Magenheim

  • Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

    Antonis C. Antoniou;Jonathan Beesley;Lesley McGuffog;Olga M. Sinilnikova

  • Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951

    Hélène Cavé;Stefan Suciu;Claude Preudhomme;Bruce Poppe

  • The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

    Joni Van der Meulen;Viraj Sanghvi;Konstantinos Mavrakis;Kaat Durinck

  • Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies.

    Bruce Poppe;Jo Vandesompele;Claudia Schoch;Charlotta Lindvall

  • Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using polygenic risk scores

    Julie Lecarpentier;Valentina Silvestri;Karoline B. Kuchenbaecker;Karoline B. Kuchenbaecker;Daniel Barrowdale

  • Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

    A Baeyens;H Thierens;K Claes;B Poppe

  • A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

    F Speleman;B Cauwelier;N Dastugue;J Cools;J Cools

  • Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.

    Heidi Van Limbergen;Bruce Poppe;Lucienne Michaux;Christian Herens

  • Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia.

    H Van Limbergen;H B Beverloo;E van Drunen;A Janssens

  • ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

    Sofie Peirs;Filip Matthijssens;Steven Goossens;Charles De Bock

Frequent Co-Authors

Kathleen Claes
Kathleen Claes Ghent University Hospital
Franki Speleman
Franki Speleman Ghent University
Anne De Paepe
Anne De Paepe Ghent University Hospital
Nadine Van Roy
Nadine Van Roy Ghent University
Jo Vandesompele
Jo Vandesompele Ghent University
Tom Taghon
Tom Taghon Ghent University
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Pieter Mestdagh
Pieter Mestdagh Ghent University
Graham G. Giles
Graham G. Giles University of Melbourne

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