D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 55 Citations 13,466 121 World Ranking 2280 National Ranking 6

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Cytokine
  • Biochemistry

His primary areas of study are Immune system, Immunology, Cell biology, Inflammasome and Innate immune system. His Immune system research integrates issues from Interleukin 18, Signal transduction and Microbiology. Immunology is closely attributed to Bordetella pertussis in his research.

His biological study spans a wide range of topics, including Proinflammatory cytokine and Cytokine. His research in Inflammasome tackles topics such as Secretion which are related to areas like Autophagy and Cellular immunity. His Innate immune system study frequently draws connections to other fields, such as Antigen.

His most cited work include:

  • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. (1115 citations)
  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes (896 citations)
  • A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis (846 citations)

What are the main themes of his work throughout his whole career to date?

Ed C. Lavelle focuses on Immunology, Immune system, Antigen, Adjuvant and Innate immune system. His Vaccination, Immunity, Cytokine, Acquired immune system and Immunogenicity investigations are all subjects of Immunology research. His research in Cytokine intersects with topics in Inflammation, Proinflammatory cytokine, Secretion and Cell biology.

His Immune system research includes elements of Lectin, Inflammasome, Antibody and Microbiology. His Antigen research focuses on T cell and how it relates to Interleukin 17 and Autoimmunity. His Adjuvant research incorporates elements of Alum, Pharmacology and Virology.

He most often published in these fields:

  • Immunology (55.97%)
  • Immune system (42.77%)
  • Antigen (29.56%)

What were the highlights of his more recent work (between 2017-2021)?

  • Immunology (55.97%)
  • Immune system (42.77%)
  • Cell biology (15.72%)

In recent papers he was focusing on the following fields of study:

His main research concerns Immunology, Immune system, Cell biology, Inflammation and Innate immune system. His Immunology research includes themes of Disease and Pneumonia. His research in Immune system intersects with topics in Adjuvant and Antigen.

His Innate immune system research is multidisciplinary, incorporating perspectives in Proinflammatory cytokine, Neurodegeneration, Cytokine and Antigen-presenting cell. His Cytokine research incorporates themes from T cell, Secretion and Effector. The various areas that he examines in his Acquired immune system study include Inflammasome and Pharmacology.

Between 2017 and 2021, his most popular works were:

  • Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing (62 citations)
  • Immunomodulatory properties of chitosan polymers (47 citations)
  • Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM (35 citations)

In his most recent research, the most cited papers focused on:

  • Immune system
  • Cytokine
  • Biochemistry

The scientist’s investigation covers issues in Immunology, Immune system, Inflammation, Cytokine and Innate immune system. His biological study focuses on Immunity. His Immune system study integrates concerns from other disciplines, such as Adjuvant and Vaccination.

His Inflammation research is multidisciplinary, incorporating elements of Neurodegeneration and Stimulator of interferon genes. His research investigates the connection with Cytokine and areas like Cell biology which intersect with concerns in Interleukin 33 and Macrophage. His biological study spans a wide range of topics, including Acquired immune system, Inflammasome and Adjuvanticity.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

Caroline E. Sutton;Stephen J. Lalor;Cheryl M. Sweeney;Corinna F. Brereton.
Immunity (2009)

1374 Citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

Caroline Sutton;Corinna Brereton;Brian Keogh;Kingston H.G. Mills.
Journal of Experimental Medicine (2006)

1113 Citations

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull.
Nature Immunology (2010)

1036 Citations

Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation

James Harris;Michelle L Hartman;Caitrionna Jane Roche;Shijuan Grace Zeng.
Journal of Biological Chemistry (2011)

771 Citations

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Alexander U. Lüthi;Sean P. Cullen;Edel A. McNeela;Patrick J. Duriez.
Immunity (2009)

685 Citations

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

Fiona A Sharp;Darren Thomas Ruane;Benjamin Claass;Emma Creagh.
Proceedings of the National Academy of Sciences of the United States of America (2009)

540 Citations

TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.

Sarah C. Higgins;Andrew G. Jarnicki;Ed C. Lavelle;Kingston H. G. Mills.
Journal of Immunology (2006)

449 Citations

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

Edel A. McNeela;Áine Burke;Daniel R. Neill;Cathy Baxter.
PLOS Pathogens (2010)

356 Citations

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

Sarah L. Doyle;Matthew Campbell;Ema Ozaki;Robert G. Salomon.
Nature Medicine (2012)

350 Citations

Toll-Like Receptor 4-Mediated Innate IL-10 Activates Antigen-Specific Regulatory T Cells and Confers Resistance to Bordetella pertussis by Inhibiting Inflammatory Pathology

Sarah C. Higgins;Ed C. Lavelle;Chantelle McCann;Brian Keogh.
Journal of Immunology (2003)

319 Citations

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