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Immunology

D-Index
67
Citations
20209
World Ranking
2650
National Ranking
8

Overview

Ed C. Lavelle is affiliated with Trinity College Dublin in Ireland and focuses on research primarily within the fields of Immunology and Microbiology as well as Medicine. Their work has contributed to various subfields including Immunology, Infectious Diseases, Molecular Biology, Cancer Research, and Epidemiology.

They have been involved in the publication of multiple scientific papers, with notable recent contributions such as:

  • Mucosal vaccines - fortifying the frontiers, 2021, Nature reviews. Immunology
  • Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages, 2021, Nature Communications
  • Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21, 2020, Cell Reports
  • Prevention and treatment of COVID-19 disease by controlled modulation of innate immunity, 2020, European Journal of Immunology
  • Modulation of immune responses using adjuvants to facilitate therapeutic vaccination, 2020, Immunological Reviews

Lavelle has co-authored with multiple frequent collaborators including Ross W. Ward, Natalia Muñoz-Wolf, Aoife L. Gorman, Roisin I. Lynch, and Filipa Lebre. These collaborations have supported their contributions to the scientific community.

Their research has been disseminated in a range of publication venues, with multiple papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature reviews. Immunology
  • Nature Communications
  • European Journal of Immunology
  • Current Opinion in Immunology

Key topics evident in Lavelle's body of work include:

  • Immunotherapy and Immune Responses
  • Immune responses and vaccinations
  • Immune Response and Inflammation
  • SARS-CoV-2 and COVID-19 Research
  • Immune cells in cancer
  • Inflammasome and immune disorders
  • Immune Cell Function and Interaction

The scope of their research broadly addresses the dynamics of immune responses, vaccinations, and inflammation, with an emphasis on understanding mechanisms relevant to infectious diseases and cancer.

Best Publications

  • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

    Caroline E. Sutton;Stephen J. Lalor;Cheryl M. Sweeney;Corinna F. Brereton

  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

    Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull

  • A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

    Caroline Sutton;Corinna Brereton;Brian Keogh;Kingston H.G. Mills

  • Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

    James Harris;Michelle L Hartman;Caitrionna Jane Roche;Shijuan Grace Zeng

  • Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

    Alexander U. Lüthi;Sean P. Cullen;Edel A. McNeela;Patrick J. Duriez

  • Mucosal vaccines - fortifying the frontiers.

    Ed C. Lavelle;Ross W. Ward

  • Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

    Fiona A Sharp;Darren Thomas Ruane;Benjamin Claass;Emma Creagh

  • The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

    Elizabeth C. Carroll;Lei Jin;Andres Mori;Natalia Muñoz-Wolf

  • TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.

    Sarah C. Higgins;Andrew G. Jarnicki;Ed C. Lavelle;Kingston H. G. Mills

  • NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

    Sarah L. Doyle;Matthew Campbell;Ema Ozaki;Robert G. Salomon

  • Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

    Edel A. McNeela;Áine Burke;Daniel R. Neill;Cathy Baxter

  • Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine

    Pádraig J. Ross;Caroline E. Sutton;Sarah Higgins;Aideen C. Allen

  • Toll-Like Receptor 4-Mediated Innate IL-10 Activates Antigen-Specific Regulatory T Cells and Confers Resistance to Bordetella pertussis by Inhibiting Inflammatory Pathology

    Sarah C. Higgins;Ed C. Lavelle;Chantelle McCann;Brian Keogh

  • Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

    Inna S. Afonina;Graham A. Tynan;Susan E. Logue;Sean P. Cullen

  • The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.

    E C Lavelle;C Murphy;L A J O’Neill;E M Creagh

  • Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

    Sean P. Cullen;Conor M. Henry;Conor J. Kearney;Susan E. Logue

  • Trends in vaccine adjuvants.

    Virgil E J C Schijns;Ed C Lavelle

  • Immunomodulatory properties of chitosan polymers

    Hannah B.T. Moran;Joanna L. Turley;Mats Andersson;Ed C. Lavelle

  • Immunomodulatory properties of the vaccine adjuvant alum.

    Ewa Oleszycka;Ed C Lavelle

  • The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.

    Filipa Lebre;Rukmani Sridharan;Michael J Sawkins;Michael J Sawkins;Daniel J Kelly;Daniel J Kelly

  • Attenuating Regulatory T Cell Induction by TLR Agonists through Inhibition of p38 MAPK Signaling in Dendritic Cells Enhances Their Efficacy as Vaccine Adjuvants and Cancer Immunotherapeutics

    Andrew G. Jarnicki;Helen Conroy;Corinna Brereton;Graham Donnelly

Frequent Co-Authors

Kingston H. G. Mills
Kingston H. G. Mills Trinity College Dublin
Derek O'hagan
Derek O'hagan GlaxoSmithKline (United Kingdom)
James S. Harris
James S. Harris Stanford University
S.S. Davis
S.S. Davis University of Nottingham
Seamus J. Martin
Seamus J. Martin Trinity College Dublin
Luke A. J. O'Neill
Luke A. J. O'Neill Trinity College Dublin
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
George Grant
George Grant University of Aberdeen
Paul F. Kenna
Paul F. Kenna Trinity College Dublin
Fergal J. O'Brien
Fergal J. O'Brien Royal College of Surgeons in Ireland

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