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Christian P. Kratz

Christian P. Kratz

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
23331
World Ranking
8071
National Ranking
594

Overview

Christian P. Kratz is affiliated with Hannover Medical School in Germany and has a substantial body of research primarily focused on oncology, genetics, and pediatrics. Their work spans several intersecting fields, including medicine, biochemistry, genetics, and molecular biology.

Their research contributions include investigations into cancer genomics, molecular biology, and childhood cancer, reflected in several recent papers published in prominent scientific journals. Significant publications include:

  • The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms, 2022, Leukemia
  • A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era, 2021, Cancer Discovery
  • The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute, 2022, Cell Death and Differentiation
  • Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set, 2021, JAMA Oncology
  • Predisposition to cancer in children and adolescents, 2021, The Lancet Child & Adolescent Health

Kratz's research topics highlight a focus on cancer-related molecular pathways, epigenetics and DNA methylation, cancer genomics and diagnostics, and quality of life issues for childhood cancer survivors. Additional thematic interests include the Hedgehog signaling pathway, DNA repair mechanisms, and sarcoma diagnosis and treatment.

They have frequently published in a range of scientific venues known for oncology and cancer research, including:

  • Familial Cancer
  • Neuro-Oncology
  • Clinical Cancer Research
  • Pediatric Blood & Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)

Kratz collaborates regularly with several researchers in related fields, with co-authoring relationships including:

  • Stefan M. Pfister
  • David Malkin
  • Kristian W. Pajtler
  • Pierre Hainaut
  • Tim Ripperger

Their body of work is distributed across multiple subfields such as molecular biology, oncology, genetics, pediatrics, perinatology and child health, as well as pathology and forensic medicine. This illustrates a broad interdisciplinary approach to understanding cancer predisposition, diagnosis, and treatment at molecular and clinical levels.

Best Publications

  • The landscape of genomic alterations across childhood cancers

    Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter

  • Germline KRAS mutations cause Noonan syndrome

    Suzanne Schubbert;Martin Zenker;Sara L . Rowe;Silke Böll

  • Comprehensive Analysis of Hypermutation in Human Cancer

    Brittany B. Campbell;Nicholas Light;David Fabrizio;Matthew Zatzman

  • Detectable clonal mosaicism and its relationship to aging and cancer

    Kevin B. Jacobs;Kevin B. Jacobs;Meredith Yeager;Meredith Yeager;Weiyin Zhou;Weiyin Zhou;Sholom Wacholder

  • BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

    Stefan Pfister;Wibke G. Janzarik;Marc Remke;Aurélie Ernst

  • Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

    Christian P. Kratz;Maria Isabel Achatz;Laurence Brugieres;Thierry Frebourg

  • Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium ‘Care for CMMRD’ (C4CMMRD)

    Katharina Wimmer;Christian P Kratz;Hans F A Vasen;Olivier Caron

  • Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.

    Frédéric Brioude;Jennifer M Kalish;Alessandro Mussa;Alison C Foster;Alison C Foster

  • Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

    Sebastian M. Waszak;Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Giles W. Robinson

  • A Syndrome with Congenital Neutropenia and Mutations in G6PC3

    Kaan Boztug;Giridharan Appaswamy;Angel Ashikov;Alejandro A. Schäffer

  • A restricted spectrum of NRAS mutations causes Noonan syndrome

    Ion C. Cirstea;Kerstin Kutsche;Radovan Dvorsky;Lothar Gremer

  • The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease

    Christian P. Kratz;Charlotte M. Niemeyer;Robert P. Castleberry;Mualla Cetin

  • Childhood cancer predisposition syndromes : A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

    Tim Ripperger;Stefan S. Bielack;Arndt Borkhardt;Ines B. Brecht;Ines B. Brecht

  • IKZF1plus Defines a New Minimal Residual Disease–Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

    Martin Stanulla;Elif Dagdan;Marketa Zaliova;Anja Möricke

  • Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes.

    Christian P. Kratz;Suthee Rapisuwon;Helen Reed;Henrik Hasle

  • Genomics and drug profiling of fatal TCF3-HLF− positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

    Ute Fischer;Michael Forster;Anna Maria Rinaldi;Thomas S. Risch

  • Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations

    Martin Zenker;Katarina Lehmann;Anna Leana Schulz;Helmut Barth

  • Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D)

    H F A Vasen;Z Ghorbanoghli;F Bourdeaut;O Cabaret

  • Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement

    Brioude F;Kalish Jm;Mussa A;Foster Ac

  • Detectable clonal mosaicism and its relationship to aging and cancer

    Kevin B. Jacobs;Meredith Yeager;Weiyin Zhou;Sholom Wacholder

Frequent Co-Authors

Charlotte M. Niemeyer
Charlotte M. Niemeyer University of Freiburg
Martin Zenker
Martin Zenker Otto-von-Guericke University Magdeburg
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Mark H. Greene
Mark H. Greene National Institutes of Health
Martin Stanulla
Martin Stanulla Hannover Medical School
Henrik Hasle
Henrik Hasle Aarhus University Hospital
Kevin Shannon
Kevin Shannon University of California, San Francisco
Meredith Yeager
Meredith Yeager Hood College
Marco Zecca
Marco Zecca University of Pavia
Sharon A. Savage
Sharon A. Savage National Institutes of Health

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