World's Best Scientists 2026 revealed!
David G. Brooks

David G. Brooks

D-Index & Metrics

Microbiology

D-Index
60
Citations
14981
World Ranking
3099
National Ranking
91

Overview

David G. Brooks is affiliated with the University of Toronto in Canada. Their work spans several fields within biomedical research, with a primary focus on immunology and microbiology as well as medicine.

The scientist's research includes key subfields such as immunology, oncology, molecular biology, pulmonary and respiratory medicine, and epidemiology. Within these areas, their studies cover diverse topics including immune cell function and interaction, cancer immunotherapy and biomarkers, T-cell and B-cell immunology, immune cells in cancer, immunotherapy and immune responses, tryptophan and brain disorders, and epigenetics and DNA methylation.

David G. Brooks has published extensively in various scientific journals. Frequent publication venues include:

  • Immunity
  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Radiation Oncology*Biology*Physics
  • Nature Immunology

Their recent papers reflect the scope of their research interests and include the following:

  • "Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity," 2022, Immunity
  • "Opposing Roles of Type I Interferons in Cancer Immunity," 2020, Annual Review of Pathology Mechanisms of Disease
  • "Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity," 2021, Nature Communications
  • "The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity," 2022, Immunity
  • "DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells," 2021, Molecular Cell

David G. Brooks has collaborated frequently with several researchers, highlighting a network of recurring co-authors. These include:

  • Giselle M. Boukhaled (17 publications)
  • Mengdi Guo (13 publications)
  • Tracy L. McGaha (11 publications)
  • Heidi Elsaesser (11 publications)
  • Pamela S. Ohashi (9 publications)

Their main contributions inside immunology focus heavily on the dynamics of immune cell behavior and cancer immunity, demonstrating a blend of molecular biology and clinical investigation.

Best Publications

  • Interleukin-10 determines viral clearance or persistence in vivo.

    David G Brooks;Matthew J Trifilo;Kurt H Edelmann;Luc Teyton

  • Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

    Elizabeth B. Wilson;Douglas H. Yamada;Heidi Elsaesser;Jonathan Herskovitz

  • IL-21 is required to control chronic viral infection.

    Heidi Elsaesser;Karsten Sauer;David G. Brooks

  • Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

    Yoko Kidani;Heidi Elsaesser;M Benjamin Hock;M Benjamin Hock;Laurent Vergnes

  • Type I Interferon in Chronic Virus Infection and Cancer

    Laura M. Snell;Tracy L. McGaha;Tracy L. McGaha;David G. Brooks;David G. Brooks

  • Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

    Autumn G. York;Kevin J. Williams;Joseph P. Argus;Quan D. Zhou

  • Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

    D G Brooks;W Q Qiu;A D Luster;J V Ravetch

  • Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

    Laura M. Fahey;Elizabeth B. Wilson;Heidi Elsaesser;Chris D. Fistonich

  • Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

    Olga L. Rojas;Anne-Katrin Pröbstel;Elisa A. Porfilio;Angela A. Wang

  • Mitochondria‐derived Reactive Oxygen Species Mediate Blue Light‐induced Death of Retinal Pigment Epithelial Cells¶

    Ayala King;Eyal Gottlieb;David G. Brooks;Michael P. Murphy

  • Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.

    Francois Gonzalvez;Zachary T. Schug;Riekelt H. Houtkooper;Elaine D. MacKenzie

  • Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection

    David G. Brooks;Luc Teyton;Michael B. A. Oldstone;Dorian B. McGavern

  • Germline Loss-of-Function Mutations in EPHB4 Cause a Second Form of Capillary Malformation-Arteriovenous Malformation (CM-AVM2) Deregulating RAS-MAPK Signaling

    Mustapha Amyere;Nicole Revencu;Raphaël Helaers;Eleonore Pairet

  • Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency

    Yael D. Korin;David G. Brooks;Stephen Brown;Andrew Korotzer

  • Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes.

    Susanna Annunen;Jarmo Körkkö;Jarmo Körkkö;Malwina Czarny;Matthew L. Warman

  • IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

    David G. Brooks;Sang Jun Ha;Heidi Elsaesser;Arlene H. Sharpe

  • Molecular characterization, reactivation, and depletion of latent HIV

    David G Brooks;Dean H Hamer;Philip A Arlen;Lianying Gao

  • Generation of HIV latency during thymopoiesis.

    David G. Brooks;Scott G. Kitchen;Christina M. R. Kitchen;Deirdre D. Scripture-Adams

  • Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype

    Deirdre D. Scripture-Adams;David G. Brooks;Yael D. Korin;Jerome A. Zack

  • The role of IL-10 in regulating immunity to persistent viral infections

    Elizabeth B. Wilson;David G. Brooks

  • IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection

    David G. Brooks;Andrew M. Lee;Heidi Elsaesser;Dorian B. McGavern

Frequent Co-Authors

Michael B. A. Oldstone
Michael B. A. Oldstone Scripps Research Institute
Jerome A. Zack
Jerome A. Zack University of California, Los Angeles
Dorian B. McGavern
Dorian B. McGavern National Institutes of Health
Trevor J. Pugh
Trevor J. Pugh Princess Margaret Cancer Centre
Mark J. Arends
Mark J. Arends University of Edinburgh
Enza Maria Valente
Enza Maria Valente University of Pavia
Dwight Stambolian
Dwight Stambolian University of Pennsylvania
Bruno Dallapiccola
Bruno Dallapiccola Bambino Gesù Children's Hospital
Wendy K. Chung
Wendy K. Chung Columbia University
Francesco Brancati
Francesco Brancati University of L'Aquila

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students pursuing Microbiology, exploring complementary online degrees can open diverse career opportunities in the healthcare sector. For instance, a strong foundation in coding and billing is crucial for efficient healthcare administration. Programs offering an cpc certification enable graduates to specialize in medical coding, a skill in high demand for managing patient records.

For those interested in leadership roles, a master in health information management salary reflects the growing value of expertise in this field. Such advanced degrees combine knowledge of healthcare, technology, and management to prepare professionals for overseeing vital health information systems.

If you want to study Health Information Management online, consider programs recognized as the best cahiim accredited him programs online. Accreditation ensures a quality education that meets industry standards and improves your employment prospects.

Additionally, for quicker entry into the healthcare workforce, online medical billing and coding certificate fast programs offer accelerated training paths. These certificates provide practical skills for immediate application and can be a stepping stone toward more advanced healthcare careers.

Best Scientists Citing David G. Brooks

Trending Scientists