World's Best Scientists 2026 revealed!
Toshifumi Inada

Toshifumi Inada

D-Index & Metrics

Molecular Biology

D-Index
63
Citations
10768
World Ranking
1822
National Ranking
148

Overview

Toshifumi Inada is affiliated with Tohoku University in Japan and works primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research focuses extensively on molecular biology, with particular attention to RNA and protein synthesis mechanisms as well as ubiquitin and proteasome pathways.

The scientist has contributed to a number of high-impact publications in various scientific journals. Some of their recent papers include:

  • Stress- and ubiquitylation-dependent phase separation of the proteasome, 2020, Nature
  • The Ccr4-Not complex monitors the translating ribosome for codon optimality, 2020, Science
  • Genome-wide Survey of Ribosome Collision, 2020, Cell Reports
  • RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1, 2020, Nature Structural & Molecular Biology
  • Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells, 2020, Scientific Reports

Frequent co-authors working alongside Toshifumi Inada include:

  • Yoshitaka Matsuo
  • Roland Beckmann
  • Ken Ikeuchi
  • Sihan Li
  • Satoshi Hashimoto

The scholar's research is also published regularly in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • Cell Reports
  • Molecular Cell

Toshifumi Inada's work covers several important topics in molecular and cellular biology, including:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Ubiquitin and proteasome pathways
  • Endoplasmic reticulum stress and disease
  • Peptidase inhibition and analysis
  • Epigenetics and DNA methylation

Specifically, their research explores the regulation of ribosome activity, quality control pathways associated with ribosome collisions, and the molecular mechanisms underlying protein degradation through ubiquitylation. This integration of cellular stress responses, RNA biology, and protein homeostasis reflects a comprehensive approach to understanding fundamental processes in cell biology and genetics.

Best Publications

  • A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

    Onn Brandman;Jacob Stewart-Ornstein;Daisy Wong;Adam Larson

  • Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli: Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant

    Bradford S. Powell;Donald L. Court;Toshifumi Inada;Yoshikazu Nakamura

  • Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA.

    Tatsuhisa Tsuboi;Kazushige Kuroha;Kazuhei Kudo;Shiho Makino

  • Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.

    Ken Ikeuchi;Petr Tesina;Yoshitaka Matsuo;Takato Sugiyama

  • Ubiquitination of stalled ribosome triggers ribosome-associated quality control

    Yoshitaka Matsuo;Ken Ikeuchi;Yasushi Saeki;Shintaro Iwasaki

  • Nascent peptide-dependent translation arrest leads to Not4p-mediated protein degradation by the proteasome.

    Lyudmila N. Dimitrova;Kazushige Kuroha;Tsuyako Tatematsu;Toshifumi Inada

  • Mechanism responsible for glucose-lactose diauxie in Escherichia coli: challenge to the cAMP model.

    Toshifumi Inada;Keiko Kimata;Hiroji Aiba

  • Stress- and ubiquitylation-dependent phase separation of the proteasome

    Sayaka Yasuda;Hikaru Tsuchiya;Ai Kaiho;Qiang Guo

  • Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeast

    Sayoko Ito-Harashima;Kazushige Kuroha;Tsuyako Tatematsu;Toshifumi Inada

  • The Ccr4-Not complex monitors the translating ribosome for codon optimality.

    Robert Buschauer;Yoshitaka Matsuo;Takato Sugiyama;Ying Hsin Chen

  • Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli.

    Teppei Morita;Hiroshi Kawamoto;Taisei Mizota;Toshifumi Inada

  • cAMP receptor protein–cAMP plays a crucial role in glucose–lactose diauxie by activating the major glucose transporter gene in Escherichia coli

    Keiko Kimata;Hideyuki Takahashi;Toshifumi Inada;Pieter Postma

  • Translation of aberrant mRNAs lacking a termination codon or with a shortened 3′‐UTR is repressed after initiation in yeast

    Toshifumi Inada;Hiroji Aiba

  • SsrA-mediated tagging and proteolysis of LacI and its role in the regulation of lac operon

    Tatsuhiko Abo;Toshifumi Inada;Kazuko Ogawa;Hiroji Aiba

  • Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest.

    Kazushige Kuroha;Mayuko Akamatsu;Lyudmila Dimitrova;Takehiko Ito

  • Implication of membrane localization of target mRNA in the action of a small RNA: mechanism of post-transcriptional regulation of glucose transporter in Escherichia coli

    Hiroshi Kawamoto;Teppei Morita;Ayumi Shimizu;Toshifumi Inada

  • Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli

    Keiko Kimata;Yuya Tanaka;Toshifumi Inada;Hiroji Aiba

  • Accumulation of glucose 6-phosphate or fructose 6-phosphate is responsible for destabilization of glucose transporter mRNA in Escherichia coli

    Teppei Morita;Waleed El-Kazzaz;Yuya Tanaka;Toshifumi Inada

  • One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs.

    Toshifumi Inada;Eric Winstall;Salvador Z. Tarun;John R. Yates

  • Ribosome Stalling during Translation Elongation Induces Cleavage of mRNA Being Translated in Escherichia coli

    Takafumi Sunohara;Kaoru Jojima;Hideaki Tagami;Toshifumi Inada

Frequent Co-Authors

Hiroji Aiba
Hiroji Aiba Suzuka University of Medical Science
Yoshikazu Nakamura
Yoshikazu Nakamura University of Tokyo
Yasushi Saeki
Yasushi Saeki Tokyo Metropolitan Institute of Medical Science
Roland Beckmann
Roland Beckmann Ludwig-Maximilians-Universität München
Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Nicholas T. Ingolia
Nicholas T. Ingolia University of California, Berkeley
Otto Berninghausen
Otto Berninghausen Ludwig-Maximilians-Universität München
Pieter W. Postma
Pieter W. Postma University of Amsterdam
Walter Neupert
Walter Neupert Max Planck Institute of Biochemistry
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring molecular biology opens doors to a wide range of online degrees and career options in the sciences and healthcare. Many students consider bridging into advanced nursing roles, where programs like online bsn to msn programs can equip you with specialized knowledge in patient care and research methodologies.

The flexibility of online education is a key advantage, especially for working professionals, parents, or those with demanding schedules. Choosing non profit universities is often beneficial, as these institutions typically provide accredited, reputable programs at a lower cost compared to many for-profit options.

For those with military experience, it’s possible to find an online college for military that offers dedicated support and benefits tailored to veterans and active-duty service members. Additionally, if you’re passionate about helping others and translating your science background into social impact, pursuing a masters in social work online could prepare you for leadership roles in community health and advocacy.

Best Scientists Citing Toshifumi Inada

Trending Scientists

Recently Published Articles