Thomas Hünig

Overview

Best Publications

• Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.

  Hubert Schorle;Thomas Holtschke;Thomas Hünig;Anneliese Schimpl

  1122
  Citations

• A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.

  T Hünig;H J Wallny;J K Hartley;A Lawetzky

  655
  Citations

• Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand

  T. Hünig;G. Tiefenthaler;K.-H. Meyer zum Büschenfelde;S. C. Meuer

  333
  Citations

• A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.

  Magdalena Huber;Sylvia Heink;Henrike Grothe;Anna Guralnik

  310
  Citations

• Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

  Chia-Huey Lin;Thomas Hünig

  289
  Citations

• The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules

  Thomas Kerkau;Igor Bacik;Jack R. Bennink;Jonathan W. Yewdell

  277
  Citations

• Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms.

  Martina Wolf;Anneliese Schimpl;Thomas Hünig

  268
  Citations

• Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

  Niklas Beyersdorf;Stefanie Gaupp;Karen Balbach;Jens Schmidt

  268
  Citations

• Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists

  Fred Lühder;Yun Huang;Kevin M. Dennehy;Christine Guntermann

  252
  Citations

• CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

  Michael Tacke;Gabriele Hanke;Thomas Hanke;Thomas Hünig

  249
  Citations

• Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

  Mario M. Zaiss;Benjamin Frey;Andreas Hess;Jochen Zwerina

  233
  Citations

• Crystal structure of a soluble CD28-Fab complex

  E J Evans;R M Esnouf;R Manso-Sancho;Gilbert Rjc.

  228
  Citations

• IMMUNOPATHOLOGY OF INTERLEUKIN (IL) 2-DEFICIENT MICE : THYMUS DEPENDENCE AND SUPPRESSION BY THYMUS-DEPENDENT CELLS WITH AN INTACT IL-2 GENE

  Susanne Kramer;Anneliese Schimpl;Thomas Hunig

  201
  Citations

• Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

  Paula S. Römer;Susanne Berr;Elita Avota;Shin Young Na

  198
  Citations

• Specificity of cytotoxic T cells from athymic mice.

  T Hünig;M J Bevan

  186
  Citations

• Differential thymus dependence of rat CD8 isoform expression.

  Nora Torres-Nagel;Elmar Kraus;Marion H. Brown;Georg Tiefenthaler

  174
  Citations

• Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo.

  Marta Rodríguez-Palmero;Toyomichi Hara;Alexander Thumbs;Thomas Hünig

  170
  Citations

• CD28 co-stimulation in T-cell homeostasis: a recent perspective

  Niklas Beyersdorf;Thomas Kerkau;Thomas Hünig

  166
  Citations

• IL-2 and autoimmune disease.

  Anneliese Schimpl;Ingolf Berberich;Burkhardt Kneitz;Susanne Krämer

  137
  Citations

• The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody.

  Thomas Hunig

  137
  Citations