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Immunology

D-Index
42
Citations
5677
World Ranking
4900
National Ranking
316

Overview

Fred Lühder is affiliated with the University of Göttingen in Germany and has an extensive research profile in the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology.

Their scientific contributions focus on several subfields including Immunology, Neurology, Molecular Biology, Oncology, and Cancer Research. Major topics within their research encompass Immunotherapy and Immune Responses, Neuroinflammation and Neurodegeneration Mechanisms, T-cell and B-cell Immunology, Autoimmune Neurological Disorders and Treatments, Cytokine Signaling Pathways and Interactions, Immune Response and Inflammation, and Immune Cell Function and Interaction.

Among their recent papers, notable publications include:

  • The Role of Glucocorticoids in Inflammatory Diseases, 2021, published in Cells
  • Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier, 2020, published in Acta Neuropathologica
  • Primidone blocks RIPK1-driven cell death and inflammation, 2020, published in Cell Death and Differentiation
  • Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects, 2022, published in Brain Behavior and Immunity
  • Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury, 2020, published in Molecular Psychiatry

Frequent co-authors collaborating with Fred Lühder include Klaus-Armin Nave, Hannelore Ehrenreich, Kirsten Hülskötter, Alexander Flügel, and Wolfgang Baumgärtner.

The scientist's work appears regularly in prominent venues such as Cells, Molecular Psychiatry, Frontiers in Immunology, Tierärztliche Praxis Ausgabe K Kleintiere / Heimtiere, and Acta Neuropathologica.

Best Publications

  • Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

    Fred Lühder;Petter Höglund;James P. Allison;Christophe Benoist

  • Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity

    Ch. Hammer;B. Stepniak;A. Schneider;S. Papiol

  • Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists

    Fred Lühder;Yun Huang;Kevin M. Dennehy;Christine Guntermann

  • Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

    Ralf A Linker;De-Hyung Lee;Seray Demir;Seray Demir;Stefan Wiese

  • Peripheral T Cells Are the Therapeutic Targets of Glucocorticoids in Experimental Autoimmune Encephalomyelitis

    Simone Wüst;Jens van den Brandt;Denise Tischner;Anna Kleiman

  • Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination.

    Ralf A. Linker;Ralf Gold;Fred Lühder

  • Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

    Fred Lühder;Cynthia Chambers;James P. Allison;Christophe Benoist

  • Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.

    Anne-Christine Flach;Tanja Litke;Judith Strauss;Michael Haberl

  • Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities.

    Fred Lühder;Jonathan Katz;Christophe Benoist;Diane Mathis

  • The role of glucocorticoids in inflammatory diseases

    Sybille D. Reichardt;Agathe Amouret;Chiara Muzzi;Sabine Vettorazzi

  • Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.

    Jan Broder Engler;Nina Kursawe;María Emilia Solano;Konstantinos Patas

  • Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.

    Simone Wüst;Denise Tischner;Michael John;Jan P. Tuckermann

  • Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

    Tea Gogishvili;Daniela Langenhorst;Fred Lühder;Fernando Elias

  • Mechanisms of Glucocorticoids in the Control of Neuroinflammation

    N. Schweingruber;S. D. Reichardt;F. Lühder;H. M. Reichardt

  • ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis

    S. Cotte;N. von Ahsen;N. Kruse;B. Huber;B. Huber

  • Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis

    Nils Schweingruber;Axel Haine;Karsten Tiede;Anna Karabinskaya

  • IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

    Ralf A. Linker;Fred Lühder;Karl-Josef Kallen;De-Hyung Lee

  • Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination

    De-Hyung Lee;Eva Geyer;Anne-Christine Flach;Klaus Jung

  • Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.

    Chiara Cordiglieri;Francesca Odoardi;Bo Zhang;Merle Nebel

  • Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model

    Hong Pan;Bárbara Oliveira;Gesine Saher;Ekrem Dere

  • Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses

    Kevin M. Dennehy;Fernando Elias;Gabrielle Zeder-Lutz;Xin Ding

  • Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.

    Tea Gogishvili;Fred Lühder;Sandra Goebbels;Sandra Beer-Hammer;Sandra Beer-Hammer

Frequent Co-Authors

Holger M. Reichardt
Holger M. Reichardt University of Göttingen
Ralf Gold
Ralf Gold Ruhr University Bochum
Thomas Hünig
Thomas Hünig University of Würzburg
Ralf Gold
Ralf Gold Ruhr University Bochum
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Hannelore Ehrenreich
Hannelore Ehrenreich Central Institute of Mental Health
Christophe Benoist
Christophe Benoist Harvard University
Diane Mathis
Diane Mathis Harvard University
Michael Sendtner
Michael Sendtner University of Würzburg
Jürgen Wienands
Jürgen Wienands University of Göttingen

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