Ralf R. Schumann

Overview

Best Publications

• Structure and function of lipopolysaccharide binding protein

  Ralf R. Schumann;Steven R. Leong;Gail W. Flaggs;Patrick W. Gray

  2204
  Citations

• Endotoxin and immune activation in chronic heart failure: a prospective cohort study.

  Josef Niebauer;Hans-Dieter Volk;Michael Kemp;Martin Dominguez

  1145
  Citations

• Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.

  Nicolas W.J. Schröder;Siegfried Morath;Christian Alexander;Lutz Hamann

  931
  Citations

• Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

  Unknown

  624
  Citations

• LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.

  N. Lamping;R. Dettmer;N. W. J. Schroder;D. Pfeil

  496
  Citations

• Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.

  F. P. Mockenhaupt;J. P. Cramer;J. P. Cramer;L. Hamann;M. S. Stegemann

  463
  Citations

• Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae.

  Bastian Opitz;Anja Püschel;Bernd Schmeck;Andreas C. Hocke

  428
  Citations

• The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs) PEPTIDOGLYCAN AND LIPOTEICHOIC ACID ARE INDUCERS OF DC MATURATION AND REQUIRE TLR2

  Kathrin S. Michelsen;Alexandra Aicher;Mariette Mohaupt;Thomas Hartung

  406
  Citations

• TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans

  Bart Ferwerda;Matthew B. B. McCall;Santos Alonso;Evangelos J. Giamarellos-Bourboulis

  404
  Citations

• Gram-Negative Bacteria Aggravate Murine Small Intestinal Th1-Type Immunopathology following Oral Infection with Toxoplasma gondii

  Markus M. Heimesaat;Stefan Bereswill;André Fischer;David Fuchs

  391
  Citations

• Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators

  Martin D. Lehner;Siegfried Morath;Kathrin S. Michelsen;Ralf R. Schumann

  375
  Citations

• Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation

  Bastian Opitz;Nicolas W.J. Schröder;Ingo Spreitzer;Kathrin S. Michelsen

  335
  Citations

• Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy

  Christopher M. Johnson;Elizabeth A. Lyle;Katherine O. Omueti;Vitaly A. Stepensky

  315
  Citations

• Heterozygous Arg753Gln Polymorphism of Human TLR-2 Impairs Immune Activation by Borrelia burgdorferi and Protects from Late Stage Lyme Disease

  Nicolas W J Schröder;Isabel Diterich;Antje Zinke;Jana Eckert

  264
  Citations

• Escherichia coli Strain Nissle 1917 Ameliorates Experimental Colitis via Toll-Like Receptor 2- and Toll-Like Receptor 4-Dependent Pathways

  A Grabig;D. Paclik;C. Guzy;A. Dankof

  262
  Citations

• Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact

  Mark M. Wurfel;Brian G. Monks;Robin R. Ingalls;Russell L. Dedrick

  248
  Citations

• Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4.

  Markus M. Heimesaat;André Fischer;Britta Siegmund;Andreas Kupz

  242
  Citations

• The role of lipopolysaccharide-binding protein in modulating the innate immune response.

  Janine Zweigner;Ralf R. Schumann;Joerg R. Weber

  238
  Citations

• TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns

  Unknown

  213
  Citations

• Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses

  Nicolas W. J. Schröder;Holger Heine;Christian Alexander;Maria Manukyan

  206
  Citations

• Escherichia coli nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling

  Andreas Sturm;Klaus Rilling;Daniel C. Baumgart;Konstantinos Gargas

  205
  Citations

• Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli

  Markus M Heimesaat;André Fischer;Hannah-Katharina Jahn;Julia Niebergall

  198
  Citations

• Streptococcal M protein: a multipotent and powerful inducer of inflammation.

  Lisa I. Påhlman;Matthias Mörgelin;Jana Eckert;Linda Johansson

  192
  Citations

• Common Polymorphisms of Toll-Like Receptors 4 and 9 Are Associated with the Clinical Manifestation of Malaria during Pregnancy

  Frank P. Mockenhaupt;Lutz Hamann;Christiane von Gaertner;George Bedu-Addo

  189
  Citations

• Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule

  Ralf R. Schumann

  186
  Citations

• Toll-like receptor 4 plays a crucial role in the immune–adrenal response to systemic inflammatory response syndrome

  Kai Zacharowski;Paula A. Zacharowski;Alexander Koch;Aida Baban

  185
  Citations

• Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.

  N Lamping;A Hoess;B Yu;T C Park

  174
  Citations