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Molecular Biology

D-Index
43
Citations
8587
World Ranking
2965
National Ranking
77

Overview

Marcel Tijsterman is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the domain of Biochemistry, Genetics and Molecular Biology, with a focused emphasis on Molecular Biology as a subfield. Other related subfields include Plant Science, Genetics, Oncology, and Aging.

The scientist's body of work covers several key topics that reflect ongoing research interests. These include:

  • CRISPR and Genetic Engineering
  • DNA Repair Mechanisms
  • Plant tissue culture and regeneration
  • Chromosomal and Genetic Variations
  • PARP inhibition in cancer therapy
  • Photosynthetic Processes and Mechanisms
  • Genetics, Aging, and Longevity in Model Organisms

Publication output by Marcel Tijsterman is distributed across several scientific journals, with a notable concentration in Nature Communications. Other frequent publication venues comprise bioRxiv (Cold Spring Harbor Laboratory), The Plant Journal, Nature Plants, and PNAS Nexus.

Selected recent papers authored or coauthored by Marcel Tijsterman include:

  • "Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance," 2021, Nature Communications
  • "CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations," 2022, Nature Communications
  • "Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways," 2023, Cell Reports
  • "BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining," 2020, Nature Communications
  • "Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini," 2021, Nature Communications

Marcel Tijsterman has collaborated extensively with colleagues such as Robin van Schendel, Joost Schimmel, Paul J. J. Hooykaas, Lejon E. M. Kralemann, and Sylvia de Pater. The frequency of joint publications suggests ongoing partnerships in various studies related to molecular biology and genetics.

Best Publications

  • Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

    Femke Simmer;Marcel Tijsterman;Susan Parrish;Susan Parrish;Sandhya P Koushika

  • Dicers at RISC; the mechanism of RNAi.

    Marcel Tijsterman;Ronald H.A Plasterk

  • The Genetics of RNA Silencing

    Marcel Tijsterman;René F. Ketting;Ronald H. A. Plasterk

  • Mapping Determinants of Gene Expression Plasticity by Genetical Genomics in C. elegans

    Yang Li;Olga Alda Álvarez;Evert W Gutteling;Marcel Tijsterman

  • RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs

    Marcel Tijsterman;René F. Ketting;Kristy L. Okihara;Titia Sijen

  • Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi

    Joris Pothof;Gijs van Haaften;Karen Thijssen;Ravi S. Kamath

  • Gene expression: long-term gene silencing by RNAi.

    Nadine L. Vastenhouw;Karin Brunschwig;Kristy L. Okihara;Fritz Müller

  • A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

    Wouter Koole;Robin van Schendel;Andrea E. Karambelas;Jane T. van Heteren

  • PPW-1, a PAZ/PIWI Protein Required for Efficient Germline RNAi, Is Defective in a Natural Isolate of C. elegans

    Marcel Tijsterman;Kristy L Okihara;Karen Thijssen;Ronald H.A Plasterk

  • Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

    Peter Zeller;Peter Zeller;Jan Padeken;Robin van Schendel;Veronique Kalck

  • Genes required for systemic RNA interference in Caenorhabditis elegans.

    Marcel Tijsterman;Robin C. May;Femke Simmer;Kristy L. Okihara

  • Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.

    Diana Zatreanu;Helen M. R. Robinson;Omar Alkhatib;Marie Boursier

  • Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.

    Evelien Kruisselbrink;Victor Guryev;Karin Brouwer;Daphne B Pontier

  • Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

    Roerink Sf;van Schendel R;Tijsterman M

  • CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans

    Selma Waaijers;Vincent Portegijs;Jana Kerver;Bennie B. L. G. Lemmens

  • The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha.

    E H Gort;G van Haaften;I Verlaan;A J Groot

  • Genomes and G-quadruplexes: for better or for worse.

    Madalena Tarsounas;Marcel Tijsterman

  • T-DNA integration in plants results from polymerase-θ-mediated DNA repair.

    Maartje van Kregten;Sylvia de Pater;Ron Romeijn;Robin van Schendel

  • FANCJ promotes DNA synthesis through G‐quadruplex structures

    Pau Castillo Bosch;Sandra Segura-Bayona;Wouter Koole;Jane T van Heteren

  • Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells

    Joost Schimmel;Hanneke Kool;Robin van Schendel;Marcel Tijsterman

Frequent Co-Authors

Ronald H. A. Plasterk
Ronald H. A. Plasterk University of Amsterdam
René F. Ketting
René F. Ketting Institute of Molecular Biology
Paul J. J. Hooykaas
Paul J. J. Hooykaas Leiden University
Jan E. Kammenga
Jan E. Kammenga Wageningen University & Research
Roland Kanaar
Roland Kanaar Erasmus University Rotterdam
Victor Guryev
Victor Guryev University Medical Center Groningen
Dik C. van Gent
Dik C. van Gent Erasmus University Rotterdam
Jeroen Essers
Jeroen Essers Erasmus University Rotterdam
Julie Ahringer
Julie Ahringer University of Cambridge
Edwin Cuppen
Edwin Cuppen Utrecht University

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