Diane E. Kelly

What is she best known for?

The fields of study she is best known for:

• Enzyme
• Gene
• Bacteria

Her primary areas of study are Candida albicans, Azole, Microbiology, Fluconazole and Sterol. Her Candida albicans research incorporates elements of Lanosterol, Sterol 14-Demethylase and Stereochemistry. Diane E. Kelly interconnects Fungicide, Ketoconazole, Biotechnology and Mutagenesis, Mutant in the investigation of issues within Azole.

Her biological study spans a wide range of topics, including Biochemistry and Enzyme. Her work in Sterol addresses subjects such as Ergosterol, which are connected to disciplines such as Heme. Her study in the field of Saccharomyces, Germline mutation and Carcinogenesis also crosses realms of Synthetic genetic array and Offspring.

Her most cited work include:

• Functional profiling of the Saccharomyces cerevisiae genome. (3578 citations)
• Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains (301 citations)
• Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6-desaturation (273 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of investigation include Biochemistry, Sterol, Azole, Microbiology and Cytochrome P450. Her research integrates issues of Azole antifungal, Mode of action, Drug resistance and Biosynthesis in her study of Sterol. The concepts of her Azole study are interwoven with issues in Fungicide, Ketoconazole, Itraconazole, Candida albicans and Drug.

Her work carried out in the field of Candida albicans brings together such families of science as Fluconazole and Active site. Her work deals with themes such as Microsome, Genome, Biotransformation and Cytochrome P450 reductase, which intersect with Cytochrome P450. Her Saccharomyces cerevisiae study is focused on Gene and Genetics.

She most often published in these fields:

• Biochemistry (55.94%)
• Sterol (31.47%)
• Azole (29.37%)

What were the highlights of her more recent work (between 2012-2021)?

• Microbiology (27.27%)
• Azole (29.37%)
• Biochemistry (55.94%)

In recent papers she was focusing on the following fields of study:

Her scientific interests lie mostly in Microbiology, Azole, Biochemistry, Lanosterol and Sterol. Her Azole research integrates issues from Itraconazole, Fluconazole, Fungicide and Candida albicans. Her Candida albicans research is multidisciplinary, incorporating perspectives in Stereochemistry and Enzyme.

Her Biochemistry study typically links adjacent topics like Biorefinery. Her work on Sterol 14-Demethylase is typically connected to Dissociation constant as part of general Lanosterol study, connecting several disciplines of science. Her Sterol research includes themes of Knockout mouse and CYP27A1.

Between 2012 and 2021, her most popular works were:

• Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. (116 citations)
• Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? (112 citations)
• Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens (87 citations)

In her most recent research, the most cited papers focused on:

• Enzyme
• Gene
• Bacteria

Diane E. Kelly mainly investigates Azole, Fungal protein, Biochemistry, Lanosterol and Microbiology. Her Azole research is multidisciplinary, incorporating elements of Biotechnology, Fungicide and Candida albicans. Her Biotechnology study incorporates themes from Microbial metabolism, Genome, Gene, Function and Biotransformation.

Her Fungal protein research also works with subjects such as

• Fluconazole and related Posaconazole, Voriconazole and Potency,
• Enzyme which is related to area like Stereochemistry and Cytochrome P450 reductase. Her Biochemistry and Ergosterol, Sterol, CYP27A1 and Cytochrome P450 investigations all form part of her Biochemistry research activities. Her work in the fields of Lanosterol, such as Sterol 14-Demethylase, overlaps with other areas such as Dissociation constant.