The scientist’s investigation covers issues in Biochemistry, Azole, Candida albicans, Microbiology and Sterol. As part of one scientific family, he deals mainly with the area of Biochemistry, narrowing it down to issues related to the Stereochemistry, and often Protein secondary structure and Monooxygenase. His research integrates issues of Lanosterol, Mechanism of action, Ketoconazole, Efflux and Fungal protein in his study of Azole.
His Candida albicans study combines topics in areas such as Fluconazole and Sterol 14-Demethylase, Demethylase. His work carried out in the field of Sterol brings together such families of science as Mutant, Ergosterol and Saccharomyces cerevisiae. His Cytochrome P450 study incorporates themes from Secondary metabolism and Gene.
Steven L. Kelly mainly investigates Biochemistry, Cytochrome P450, Sterol, Microbiology and Gene. His work focuses on many connections between Cytochrome P450 and other disciplines, such as Stereochemistry, that overlap with his field of interest in Active site. Steven L. Kelly has researched Sterol in several fields, including Ustilago, Amphotericin B and Ergosterol.
His study in Azole, Fluconazole and Aspergillus fumigatus are all subfields of Microbiology. Steven L. Kelly combines subjects such as Fungicide, Lanosterol, Ketoconazole, Mutant and Candida albicans with his study of Azole. To a larger extent, Steven L. Kelly studies Genetics with the aim of understanding Gene.
His primary scientific interests are in Gene, Botany, Biochemistry, Computational biology and Evolutionary biology. His Gene study is associated with Genetics. The Sterol, Enzyme and Cytochrome P450 research Steven L. Kelly does as part of his general Biochemistry study is frequently linked to other disciplines of science, such as Pregnane X receptor and Activity-based proteomics, therefore creating a link between diverse domains of science.
His study looks at the relationship between Sterol and topics such as IC50, which overlap with Microbiology. His research on Computational biology also deals with topics like
Steven L. Kelly focuses on Gene, Computational biology, Inference, Microbiology and Genome. Gene is the subject of his research, which falls under Genetics. His Inference research is multidisciplinary, incorporating perspectives in Gene duplication, Tree and Comparative genomics.
His Microbiology research includes themes of Efflux, Aspergillosis and Ergosterol. His Genome study combines topics from a wide range of disciplines, such as Virus, Ferredoxin, Euglena gracilis and Cytochrome P450 reductase. Steven L. Kelly works on Biochemistry which deals in particular with Cytochrome P450.
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Functional profiling of the Saccharomyces cerevisiae genome.
Guri Giaever;Angela M. Chu;Li Ni;Carla Connelly.
OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy
David M. Emms;Steven Kelly.
Genome Biology (2015)
Itraconazole resistance in Aspergillus fumigatus.
David W. Denning;K. Venkateswarlu;Karen L. Oakley;M. J. Anderson.
Antimicrobial Agents and Chemotherapy (1997)
Molecular basis of resistance to azole antifungals
Antonella Lupetti;Romano Danesi;Mario Campa;Mario Del Tacca.
Trends in Molecular Medicine (2002)
OrthoFinder: phylogenetic orthology inference for comparative genomics
David M. Emms;Steven Kelly.
Genome Biology (2019)
TransRate: reference-free quality assessment of de novo transcriptome assemblies
Richard Smith-Unna;Chris Boursnell;Rob Patro;Julian M. Hibberd.
Genome Research (2016)
Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains
Renate Franz;Steven L. Kelly;David C. Lamb;Diane E. Kelly.
Antimicrobial Agents and Chemotherapy (1998)
Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6-desaturation
S.L Kelly;D.C Lamb;D.E Kelly;N.J Manning.
FEBS Letters (1997)
Mode of Action and Resistance to Azole Antifungals Associated with the Formation of 14α-Methylergosta-8,24(28)-dien-3β,6α-diol
S.L. Kelly;D.C. Lamb;A.J. Corran;B.C. Baldwin.
Biochemical and Biophysical Research Communications (1995)
The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity
David C. Lamb;Diane E. Kelly;Wolf-Hagen Schunck;Akbar Z. Shyadehi.
Journal of Biological Chemistry (1997)
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