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Joachim Morschhäuser

Joachim Morschhäuser

D-Index & Metrics

Microbiology

D-Index
64
Citations
13455
World Ranking
2630
National Ranking
199

Overview

Joachim Morschhäuser is affiliated with the University of Würzburg in Germany. Their research primarily focuses on antifungal resistance and susceptibility, fungal infections and studies, and fungal and yeast genetics research. The main academic fields of their work are Medicine and Biochemistry, Genetics, and Molecular Biology, with subfields including Infectious Diseases, Epidemiology, Molecular Biology, Oncology, and Plant Science.

Their recent publications span a range of topics related to fungal pathogens and resistance mechanisms. Notable papers include:

  • A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris (2020, mSphere)
  • Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans (2020, mBio)
  • Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance (2022, Antimicrobial Agents and Chemotherapy)
  • The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans (2022, PLoS Pathogens)
  • The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans (2021, Molecular Microbiology)

The frequent coauthors in their research include Bernardo Ramírez-Zavala, P. David Rogers, Inès Krüger, Katherine S. Barker, and Christina A. Cuomo. These collaborations reflect ongoing partnerships across various studies focused on fungal biology and pathogenesis.

Joachim Morschhäuser's work has been published predominantly in journals such as mSphere, Antimicrobial Agents and Chemotherapy, PLoS Pathogens, bioRxiv (Cold Spring Harbor Laboratory), and mBio. This selection indicates engagement with both peer-reviewed journals and preprint platforms relevant to microbiology and infectious disease research.

The main topics covered in their research are:

  • Antifungal resistance and susceptibility
  • Fungal infections and studies
  • Fungal and yeast genetics research
  • Peptidase inhibition and analysis
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Polyamine metabolism and applications
  • Probiotics and fermented foods

Best Publications

  • The SAT1 flipper, an optimized tool for gene disruption in Candida albicans.

    Oliver Reuss;Ashild Vik;Roberto Kolter;Joachim Morschhäuser

  • A Mutation in Tac1p, a Transcription Factor Regulating CDR1 and CDR2, Is Coupled With Loss of Heterozygosity at Chromosome 5 to Mediate Antifungal Resistance in Candida albicans

    Alix T. Coste;Vincent Turner;Françoise Ischer;Joachim Morschhäuser

  • Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains

    Renate Franz;Steven L. Kelly;David C. Lamb;Diane E. Kelly

  • A Human-Curated Annotation of the Candida albicans Genome

    Burkhard R Braun;Marco van het Hoog;Christophe d'Enfert;Mikhail Martchenko

  • Regulation of multidrug resistance in pathogenic fungi

    Joachim Morschhäuser

  • The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.

    Joachim Morschhäuser;Katherine S Barker;Teresa T Liu;Julia Blaß-Warmuth

  • Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains.

    Nico Dunkel;Julia Blaß;P. David Rogers;Joachim Morschhäuser

  • A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

    Nico Dunkel;Teresa T. Liu;Katherine S. Barker;Ramin Homayouni

  • The genetic basis of fluconazole resistance development in Candida albicans.

    Joachim Morschhäuser

  • Tetracycline-Inducible Gene Expression and Gene Deletion in Candida albicans

    Yang-Nim Park;Joachim Morschhäuser

  • Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

    Stephanie A. Flowers;Katherine S. Barker;Elizabeth L. Berkow;Geoffrey Toner

  • Differential activation of a Candida albicans virulence gene family during infection

    Peter Staib;Marianne Kretschmar;Thomas Nichterlein;Herbert Hof

  • Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates.

    Stephanie Wirsching;Sonja Michel;Joachim Morschhäuser

  • The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans.

    Kajal Biswas;Joachim Morschhäuser

  • Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination.

    Joachim Morschhäuser;Sonja Michel;Peter Staib

  • Environmental induction of white-opaque switching in Candida albicans.

    Bernardo Ramírez-Zavala;Oliver Reuß;Yang-Nim Park;Knut Ohlsen

  • Molecular aspects of fluconazole resistance development in Candida albicans.

    Renate Franz;M. Ruhnke;J. Morschhäuser

  • Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.

    Stefanie Allert;Toni M. Förster;Carl-Magnus Svensson;Jonathan P. Richardson

  • Chlamydospore formation on Staib agar as a species-specific characteristic of Candida dubliniensis.

    P Staib;J Morschhäuser

  • An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans.

    Clemens J. Heilmann;Sabrina Schneider;Katherine S. Barker;P. David Rogers

  • Host-induced, stage-specific virulence gene activation in Candida albicans during infection.

    Peter Staib;Marianne Kretschmar;Thomas Nichterlein;Gerwald Köhler

Frequent Co-Authors

Jörg Hacker
Jörg Hacker University of Würzburg
P. David Rogers
P. David Rogers St. Jude Children's Research Hospital
Bernhard Hube
Bernhard Hube Leibniz Association
Joerg Hacker
Joerg Hacker University of Würzburg
Ilse D. Jacobsen
Ilse D. Jacobsen Leibniz Association
Gerhard Bringmann
Gerhard Bringmann University of Würzburg
Knut Ohlsen
Knut Ohlsen University of Würzburg
Derek J. Sullivan
Derek J. Sullivan Trinity College Dublin
Ute Hentschel
Ute Hentschel GEOMAR Helmholtz Centre for Ocean Research Kiel
Herbert Hof
Herbert Hof Heidelberg University

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