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Microbiology

D-Index
91
Citations
28805
World Ranking
653
National Ranking
305

Overview

David L. Williams is affiliated with East Tennessee State University in the United States. Their research spans several intersecting fields, primarily focusing on immunology and related biomedical sciences.

The main fields of study for Williams include Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Key subfields encompass Immunology, Molecular Biology, Epidemiology, Infectious Diseases, and Cardiology and Cardiovascular Medicine.

Williams's research topics cover a range of specialized areas, notably:

  • Immune responses and vaccinations
  • Immune cells in cancer
  • Antifungal resistance and susceptibility
  • Phagocytosis and Immune Regulation
  • Sepsis Diagnosis and Treatment
  • Immune Response and Inflammation
  • Neuroinflammation and Neurodegeneration Mechanisms

Among Williams's recent published papers are:

  • Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis, 2021, Cell Death and Differentiation
  • Trained immunity, tolerance, priming and differentiation: distinct immunological processes, 2020, Nature Immunology
  • Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection, 2020, Immunity
  • Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction, 2023, Science Advances
  • Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling, 2020, Frontiers in Immunology

Frequently publishing venues for Williams include:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Leukocyte Biology
  • The Journal of Immunology
  • Nature Immunology

Collaborations form a prominent part of Williams's academic output. Regular coauthors include Douglas W. Lowman, Zuchao Ma, Kun Yang, Min Fan, and Tuanzhu Ha, each contributing significantly to shared research projects.

Best Publications

  • Dectin-1 Mediates the Biological Effects of β-Glucans

    Gordon D A Brown;Jurgen Herre;David L. Williams;Janet A Willment

  • Dectin-1 Is A Major β-Glucan Receptor On Macrophages

    Gordon D. Brown;Philip Russel Taylor;Delyth M. Reid;Janet A. Willment

  • Characterization of the human cysteinyl leukotriene CysLT1 receptor.

    K. R. Lynch;G. P. O'neill;Qingyun Liu;D.-S. Im

  • Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

    Neil C. Rogers;Emma Wetter Slack;Alexander D. Edwards;Martijn A. Nolte

  • Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

    Mihai G. Netea;Neil A.R. Gow;Carol A. Munro;Steven Bates

  • Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

    Bart Ferwerda;Gerben Ferwerda;Theo S. Plantinga;Janet A. Willment

  • Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

    Rob J.W. Arts;Boris Novakovic;Rob ter Horst;Agostinho Carvalho

  • Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis.

    Kun Yang;Kun Yang;Min Fan;Min Fan;Xiaohui Wang;Xiaohui Wang;Jingjing Xu

  • The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

    Chad Steele;Rekha R. Rapaka;Allison Metz;Shannon M. Pop

  • Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

    Maziar Divangahi;Peter Aaby;Shabaana A. Khader;Luis B. Barreiro

  • Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

    Jurgen Herre;Andrew S J Marshall;Emmanuelle Caron;Alexander D Edwards

  • Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.

    Kevin M. Dennehy;Gerben Ferwerda;Inês Faro-Trindade;Elwira Pyz

  • Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity.

    Ekaterini Tsiapali;Sarah Whaley;John Kalbfleisch;Harry E Ensley;Harry E Ensley

  • Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.

    Peter J. Rice;Elizabeth L. Adams;Tammy Ozment-Skelton;Andres J. Gonzalez

  • The macrophage mannose receptor induces IL-17 in response to Candida albicans.

    Frank L. van de Veerdonk;Renoud J. Marijnissen;Bart Jan Kullberg;Hans J.P.M. Koenen

  • Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.

    Cedric Bosteels;Katrijn Neyt;Manon Vanheerswynghels;Mary J. van Helden

  • The influence of glucan polymer structure and solution conformation on binding to (1→3)-β-d-glucan receptors in a human monocyte-like cell line

    Antje Mueller;John Raptis;Peter J. Rice;John H. Kalbfleisch

  • Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching.

    Elizabeth L. Adams;Peter J. Rice;Bridget Graves;Harry E. Ensley

  • Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

    Daniela C. Ifrim;Jessica Quintin;Leo A. B. Joosten;Cor Jacobs

  • The human β‐glucan receptor is widely expressed and functionally equivalent to murine Dectin‐1 on primary cells

    Janet A Willment;Andrew S J Marshall;Delyth M Reid;David L Williams

  • Dendritic Cell Interaction with Candida albicans Critically Depends on N-Linked Mannan

    Alessandra Cambi;Mihai G. Netea;Hector M. Mora-Montes;Neil A. R. Gow

  • Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide.

    Janet A Willment;Hsi-Hsien Lin;Delyth M Reid;Philip R Taylor

  • Comparative tumor‐inhibitory and anti‐bacterial activity of soluble and particulate glucan

    N. R. di Luzio;D. L. Williams;R. B. McNamee;B. F. Edwards

Frequent Co-Authors

Gordon D. Brown
Gordon D. Brown University of Exeter
Siamon Gordon
Siamon Gordon University of Oxford
Edward R. Sherwood
Edward R. Sherwood Vanderbilt University Medical Center
Philip R. Taylor
Philip R. Taylor Cardiff University
Mihai G. Netea
Mihai G. Netea Radboud University
Xiang Gao
Xiang Gao Nanjing University
Neil A. R. Gow
Neil A. R. Gow University of Exeter
Jos W. M. van der Meer
Jos W. M. van der Meer Radboud University Medical Center
Leo A. B. Joosten
Leo A. B. Joosten Radboud University
Richard Calderone
Richard Calderone Georgetown University Medical Center

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