World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
88
Citations
31704
World Ranking
13056
National Ranking
6668

Overview

Steven M. Paul is affiliated with Washington University in St. Louis in the United States. Their research focuses extensively on medicine, with a strong emphasis on subfields including physiology, molecular biology, cognitive neuroscience, psychiatry and mental health, and neurology.

Their main research topics cover a range of areas, most notably:

  • Alzheimer's disease research and treatments
  • Dementia and cognitive impairment research
  • Functional brain connectivity studies
  • Bioinformatics and genomic networks
  • Neural dynamics and brain function
  • Genetic associations and epidemiology
  • EEG and brain-computer interfaces

Steven M. Paul has contributed to multiple recent scientific papers, including:

  • Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease (2021), published in JAMA Neurology
  • Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer's Pathophysiology (2020), published in Scientific Reports
  • Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia (2022), published in American Journal of Psychiatry
  • Deep learning-based polygenic risk analysis for Alzheimer's disease prediction (2023), published in Communications Medicine
  • An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease (2022), published in Nature Aging

Frequent coauthors of Steven M. Paul include:

  • John C. Morris
  • Michael W. Weiner
  • Arthur W. Toga
  • Laurel Beckett
  • Andrew J. Saykin

They have published regularly in several scientific venues, predominantly:

  • Scientific Reports (6 publications)
  • JAMA Neurology (3 publications)
  • GeroScience (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • International Journal of Research and Review (3 publications)

Their work encompasses multiple facets of Alzheimer's disease and dementia research, contributing to fields that intersect neurology, molecular biology, and psychiatry. This multidisciplinary approach is reflected in their collaboration with leading researchers and publications in respected medical and neuroscience journals.

Best Publications

  • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

    Ronald B. DeMattos;Kelly R. Bales;David J. Cummins;Jean-Cosme Dodart

  • Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

    Joseph M. Castellano;Jungsu Kim;Floy R. Stewart;Hong Jiang

  • Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

    Jean Cosme Dodart;Kelly R. Bales;Kimberley S. Gannon;Stephen J. Greene

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

    David M. Holtzman;Kelly R. Bales;Tanya Tenkova;Anne M. Fagan

  • Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

    Kelly R. Bales;Tatyana Verina;Richard C. Dodel;Richard C. Dodel;Yansheng Du

  • TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

    Peng Yuan;Carlo Condello;C. Dirk Keene;Yaming Wang

  • Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

    Olav M. Andersen;Juliane Reiche;Vanessa Schmidt;Michael Gotthardt

  • Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

    Ronald B. DeMattos;Kelly R. Bales;David J. Cummins;Steven M. Paul;Steven M. Paul

  • Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

    Milla Koistinaho;Suizhen Lin;Xin Wu;Michail Esterman

  • Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.

    Kelly R. Bales;Tatyana Verina;David J. Cummins;Yansheng Du

  • In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

    John R. Cirrito;Patrick C. May;Mark A. O'Dell;Jennie W. Taylor

  • Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

    Alexandra L Young;Razvan V Marinescu;Neil P Oxtoby;Martina Bocchetta

  • ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition: Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo

    Ronald B DeMattos;John R Cirrito;Maia Parsadanian;Patrick C May

  • Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

    Margaret M. Racke;Laura I. Boone;Deena L. Hepburn;Maia Parsadainian

  • Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß42 by Inhibiting Rho

    Yan Zhou;Yuan Su;Baolin Li;Feng Liu

  • A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.

    Randall J. Bateman;Eric R. Siemers;Kwasi G. Mawuenyega;Guolin Wen

  • Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

    Suzanne E. Wahrle;Hong Jiang;Maia Parsadanian;Jungsu Kim

  • Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

    David M. Holtzman;Kelly R. Bales;Shan Wu;Priyanka Bhat

  • Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

    David M. Holtzman;Anne M. Fagan;Brian Mackey;Tanya Tenkova

Frequent Co-Authors

Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
William Z. Potter
William Z. Potter National Institutes of Health
Steven E. Arnold
Steven E. Arnold Harvard University
Paul S. Aisen
Paul S. Aisen University of Southern California
Ronald G. Crystal
Ronald G. Crystal Cornell University
Reisa A. Sperling
Reisa A. Sperling Brigham and Women's Hospital
Peter J. Snyder
Peter J. Snyder University of Rhode Island
Marilyn S. Albert
Marilyn S. Albert Johns Hopkins University School of Medicine
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Maja Bucan
Maja Bucan University of Pennsylvania

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