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Immunology

D-Index
62
Citations
16537
World Ranking
3112
National Ranking
268

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Sophie Hambleton is affiliated with Newcastle University in the United Kingdom. Their research spans multiple interconnected fields within biomedical science, primarily focusing on Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these broad domains, Hambleton's work concentrates on subfields such as Immunology, Genetics, Molecular Biology, Hematology, and Infectious Diseases.

Their research topics cover a range of areas including Immunodeficiency and Autoimmune Disorders, Immune Cell Function and Interaction, Hematopoietic Stem Cell Transplantation, Blood Disorders and Treatments, Cytomegalovirus and Herpesvirus Research, T-cell and B-cell Immunology, and Interferon and Immune Responses.

Sophie Hambleton has collaborated frequently with several researchers, including Andrew R. Gennery, Mary Slatter, C.J. Duncan, Su Han Lum, and Zohreh Nademi. These partnerships indicate a strong network within the fields of immunology and clinical medicine.

The following venues have frequently published their work:

  • Journal of Clinical Immunology
  • Journal of Allergy and Clinical Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Frontiers in Immunology

Among recent papers authored or coauthored by Hambleton are:

  • Single-cell multi-omics analysis of the immune response in COVID-19, 2021, Nature Medicine
  • Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine, 2021, Cell
  • Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans, 2020, Immunity
  • The expansion of human T-bet high CD21 low B cells is T cell dependent, 2021, Science Immunology
  • Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2, 2021, Nature Communications

Sophie Hambleton has been recognized as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • Varicella zoster virus infection.

    Anne A. Gershon;Judith Breuer;Jeffrey I. Cohen;Randall J. Cohrs

  • Rapid Effector Function in CD8+ Memory T Cells

    Ajit Lalvani;Roger Brookes;Sophie Hambleton;Warwick J. Britton

  • A robust model for read count data in exome sequencing experiments and implications for copy number variant calling

    Vincent Plagnol;James Curtis;Michael Epstein;Kin Y. Mok

  • Single-cell multi-omics analysis of the immune response in COVID-19.

    Emily Stephenson;Gary Reynolds;Rachel A Botting;Fernando J Calero-Nieto

  • IRF8 mutations and human dendritic-cell immunodeficiency.

    Sophie Hambleton;Sandra Salem;Jacinta Bustamante;Venetia Bigley

  • Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

    Joshua D. Milner;Tiphanie P. Vogel;Lisa Forbes;Chi A. Ma

  • Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

    Rachel Emma Dickinson;Helen Griffin;Venetia Bigley;Louise N. Reynard

  • Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

    Charlotte Schwab;Annemarie Gabrysch;Peter Olbrich;Virginia Patiño

  • Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

    Satoshi Okada;Satoshi Okada;Janet G Markle;Elissa K Deenick;Elissa K Deenick;Federico Mele

  • The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

    Venetia Bigley;Muzlifah Haniffa;Sergei Doulatov;Xiao-Nong Wang

  • Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study

    Daniele Moratto;Silvia Giliani;Carmem Bonfim;Evelina Mazzolari

  • Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine.

    R P Payne;S Longet;J A Austin;D T Skelly

  • STAT2 deficiency and susceptibility to viral illness in humans

    Sophie Hambleton;Stephen Goodbourn;Dan F. Young;Paul Dickinson

  • Human IFNAR2 deficiency : lessons for antiviral immunity

    Christopher J. A. Duncan;Christopher J. A. Duncan;Siti M. B. Mohamad;Siti M. B. Mohamad;Dan Frushard Young;Andrew J. Skelton

  • The evolution of cellular deficiency in GATA2 mutation

    Rachel E. Dickinson;Paul Milne;Laura Jardine;Sasan Zandi

  • Preventing Varicella-Zoster Disease

    Sophie Hambleton;Anne A. Gershon

  • Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans.

    Urszula Cytlak;Anastasia Resteu;Sarah Pagan;Kile Green

  • Whole-Exome-Sequencing-Based Discovery of Human FADD Deficiency

    Alexandre Bolze;Minji Byun;David McDonald;Neil V. Morgan

  • Low-strength T-cell activation promotes Th17 responses.

    Harriet A. Purvis;Jeroen N. Stoop;Jelena Mann;Steven Woods

  • Human dendritic cell deficiency: the missing ID?

    Matthew Collin;Venetia Bigley;Muzlifah Haniffa;Sophie Hambleton

  • T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study.

    A Angyal;S Longet;S C Moore;R P Payne

Frequent Co-Authors

Andrew J. Cant
Andrew J. Cant Newcastle University
Mario Abinun
Mario Abinun Newcastle University
Andrew R. Gennery
Andrew R. Gennery Newcastle University
Mary Slatter
Mary Slatter Newcastle University
Matthew Collin
Matthew Collin Newcastle University
Peter D. Arkwright
Peter D. Arkwright University of Manchester
Persis Amrolia
Persis Amrolia Great Ormond Street Hospital
Neil V. Morgan
Neil V. Morgan University of Birmingham
Paul Veys
Paul Veys Great Ormond Street Hospital
Stephan Ehl
Stephan Ehl University of Freiburg

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