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Shunji Sugawara

Shunji Sugawara

D-Index & Metrics

Immunology

D-Index
49
Citations
7706
World Ranking
4360
National Ranking
168

Overview

Shunji Sugawara is affiliated with Tohoku University in Japan and has a body of research primarily focused on medicine and immunology and microbiology. Their work intersects several subfields, including immunology, physiology, oncology, immunology and allergy, and molecular biology.

The main topics explored in Sugawara's research include:

  • Immune Response and Inflammation
  • Bone health and treatments
  • Immune Cell Function and Interaction
  • Salivary Gland Disorders and Functions
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Bone and Joint Diseases
  • Allergic Rhinitis and Sensitization

Recent publications attributed to Sugawara cover a range of biomedical and immunological subjects. Representative papers include:

  • Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands, 2022, Scientific Reports
  • Nitrogen-containing bisphosphonates and lipopolysaccharide mutually augment inflammation via adenosine triphosphate (ATP)-mediated and interleukin 1β (IL-1β)-mediated production of neutrophil extracellular traps (NETs), 2020, Journal of Bone and Mineral Research
  • Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells, 2021, Journal of Innate Immunity
  • Hericium erinaceus ethanol extract and ergosterol exert anti-inflammatory activities by neutralizing lipopolysaccharide-induced pro-inflammatory cytokine production in human monocytes, 2022, Biochemical and Biophysical Research Communications
  • Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities, 2020, Scientific Reports

Sugawara has published frequently in several journals, with notable publication counts in:

  • Biochemical and Biophysical Research Communications (3 publications)
  • Scientific Reports (2 publications)
  • Biological and Pharmaceutical Bulletin (2 publications)
  • Inflammation Research (2 publications)
  • Research Square (2 publications)

Collaboration plays a role in Sugawara's research output, working repeatedly with several co-authors. Those frequently collaborating include:

  • Yukinori Tanaka (9 joint publications)
  • Kanan Bando (9 joint publications)
  • Toshinobu Kuroishi (7 joint publications)
  • Itaru Mizoguchi (6 joint publications)
  • Hiroyuki Tada (5 joint publications)

Best Publications

  • Saccharomyces cerevisiae- and Candida albicans-Derived Mannan Induced Production of Tumor Necrosis Factor Alpha by Human Monocytes in a CD14- and Toll-Like Receptor 4-Dependent Manner

    Hiroyuki Tada;Eiji Nemoto;Hidetoshi Shimauchi;Toshihiko Watanabe

  • Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells.

    Shunji Sugawara;Akiko Uehara;Tomonori Nochi;Takahiro Yamaguchi

  • Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjögren’s Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18

    Azusa Sakai;Yumiko Sugawara;Toshinobu Kuroishi;Takashi Sasano

  • Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.

    A. Uehara;S. Yang;Y. Fujimoto;K. Fukase

  • Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture.

    Shuhua Yang;Riyoko Tamai;Sachiko Akashi;Osamu Takeuchi

  • Toll-like Receptors, NOD1, and NOD2 in Oral Epithelial Cells

    Y. Sugawara;A. Uehara;Y. Fujimoto;S. Kusumoto

  • A simple method to eliminate the antigenicity of surface class I MHC molecules from the membrane of viable cells by acid treatment at pH 3

    Shunji Sugawara;Toru Abo;Katsuo Kumagai

  • Neutrophil Serine Proteinases Activate Human Nonepithelial Cells to Produce Inflammatory Cytokines Through Protease-Activated Receptor 2

    Akiko Uehara;Koji Muramoto;Haruhiko Takada;Shunji Sugawara

  • Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells

    A. Uehara;Y. Sugawara;S. Kurata;Y. Fujimoto

  • Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsiveness

    Shunji Sugawara;Eiji Nemoto;Hiroyuki Tada;Kensuke Miyake

  • Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell-surface components through the CD14/Toll-like receptor system

    J. Hatakeyama;R. Tamai;A. Sugiyama;S. Akashi

  • Priming of human oral epithelial cells by interferon-γ to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans

    A. Uehara;S. Sugawara;H. Takada

  • Suppression of Stress Protein GRP78 Induction in Tumor B/C10ME Eliminates Resistance to Cell Mediated Cytotoxicity

    Shunji Sugawara;Kazuyoshi Takeda;Amy Lee;Gunther Dennert

  • Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase

    N. Sato;M. Kinbara;T. Kuroishi;K. Kimura

  • Heterogeneous Expression and Release of CD14 by Human Gingival Fibroblasts: Characterization and CD14-Mediated Interleukin-8 Secretion in Response to Lipopolysaccharide

    Shunji Sugawara;Akiko Sugiyama;Eiji Nemoto;Hidemi Rikiishi

  • Activation of Human Oral Epithelial Cells by Neutrophil Proteinase 3 Through Protease-Activated Receptor-2

    Akiko Uehara;Shunji Sugawara;Koji Muramoto;Haruhiko Takada

  • Age-related variation in the proportion and activity of murine liver natural killer cells and their cytotoxicity against regenerating hepatocytes.

    H Itoh;T Abo;S Sugawara;A Kanno

  • Elevated extracellular calcium stimulates secretion of bone morphogenetic protein 2 by a macrophage cell line

    Yoshitomo Honda;Takahisa Anada;Shinji Kamakura;Masanori Nakamura

  • Contrasting responses of human gingival and colonic epithelial cells to lipopolysaccharides, lipoteichoic acids and peptidoglycans in the presence of soluble CD14

    Akiko Uehara;Shunji Sugawara;Riyoko Tamai;Haruhiko Takada

  • Induction of human TCRγδ+ and TCRγδ− CD2 + CD3 − double negative lymphocytes by bacterial stimulation

    Toru Abo;Shunji Sugawara;Shuhji Seki;Manahiko Fujii

  • Variation in CD4+ T and CD8+ T lymphocyte subpopulations in bovine mammary gland secretions during lactating and non-lactating periods.

    Ken Ichi Asai;Kenzo Kai;Hidemi Rikiishi;Shunji Sugawara

Frequent Co-Authors

Haruhiko Takada
Haruhiko Takada Tohoku University
Katsuo Kumagai
Katsuo Kumagai Tohoku University
Koji Muramoto
Koji Muramoto Tohoku University
Yoichiro Iwakura
Yoichiro Iwakura Tokyo University of Science
Gunther Dennert
Gunther Dennert University of Southern California
Osamu Takeuchi
Osamu Takeuchi Kyoto University
Koichi Fukase
Koichi Fukase Osaka University
Toru Abo
Toru Abo Niigata University
Shizuo Akira
Shizuo Akira Osaka University
Jan Potempa
Jan Potempa University of Louisville

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