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Immunology

D-Index
65
Citations
20378
World Ranking
2810
National Ranking
1327

Overview

Rosa Bacchetta is affiliated with Stanford University in the United States. Their research primarily focuses on immunology and microbiology, with significant contributions also in the field of medicine. The main subfields of study include immunology, oncology, hematology, epidemiology, and genetics. Their work spans a range of topics such as immune cell function and interaction, T-cell and B-cell immunology, CAR-T cell therapy research, immunodeficiency and autoimmune disorders, hematopoietic stem cell transplantation, cytomegalovirus and herpesvirus research, and adrenal hormones and disorders.

Frequent publishing venues for Bacchetta's research include Frontiers in Immunology, Cytotherapy, bioRxiv (Cold Spring Harbor Laboratory), Journal of Allergy and Clinical Immunology, and Transplantation and Cellular Therapy.

Recent notable papers authored or co-authored by Bacchetta are:

  • Human inborn errors of immunity: An expanding universe, 2020, Science Immunology
  • CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells, 2020, Science Advances
  • Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey, 2020, Frontiers in Immunology
  • Alloantigen-specific type 1 regulatory T cells suppress through CTLA-4 and PD-1 pathways and persist long-term in patients, 2021, Science Translational Medicine
  • Human-engineered Treg-like cells suppress FOXP3-deficient T cells but preserve adaptive immune responses in vivo, 2020, Clinical & Translational Immunology

Frequent co-authors collaborating with Bacchetta include Maria Grazia Roncarolo, Alice Bertaina, Alma-Martina Cepika, Mansi Narula, and Šimon Borna.

Best Publications

  • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

    Maria Grazia Roncarolo;Silvia Gregori;Manuela Battaglia;Rosa Bacchetta

  • Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

    Ayal Hendel;Rasmus O Bak;Joseph T Clark;Andrew B Kennedy

  • Type 1 T regulatory cells.

    Maria Grazia Roncarolo;Rosa Bacchetta;Claudio Bordignon;Satwant Narula

  • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

    Sarah E. Allan;Sarah Q. Crome;Natasha K. Crellin;Laura Passerini

  • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

    Nicola Gagliani;Chiara F. Magnani;Samuel Huber;Monica E. Gianolini;Monica E. Gianolini

  • Reprogramming human T cell function and specificity with non-viral genome targeting

    Theodore L. Roth;Cristina Puig-Saus;Ruby Yu;Ruby Yu;Eric Shifrut;Eric Shifrut

  • Defective regulatory and effector T cell functions in patients with FOXP3 mutations

    Rosa Bacchetta;Laura Passerini;Eleonora Gambineri;Minyue Dai

  • The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

    Sarah E. Allan;Laura Passerini;Rosa Bacchetta;Natasha Crellin

  • The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

    Megan K. Levings;Rosa Bacchetta;Ute Schulz;Maria Grazia Roncarolo

  • High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

    R Bacchetta;M Bigler;J L Touraine;R Parkman

  • Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A Paradigm of Immunodeficiency with Autoimmunity

    Federica Barzaghi;Laura Passerini;Rosa Bacchetta

  • From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

    Rosa Bacchetta;Federica Barzaghi;Maria Grazia Roncarolo

  • Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

    Cristina Woellner;E. Michael Gertz;Alejandro A. Schäffer;Macarena Lagos

  • Role of regulatory T cells and FOXP3 in human diseases.

    Rosa Bacchetta;Eleonora Gambineri;Maria Grazia Roncarolo

  • Tr1 cells: from discovery to their clinical application.

    Manuela Battaglia;Silvia Gregori;Rosa Bacchetta;Maria Grazia Roncarolo

  • The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.

    Maria Grazia Roncarolo;Silvia Gregori;Rosa Bacchetta;Manuela Battaglia

  • Erratum: Interleukin-10- secreting type 1 regulatory T cells in rodents and humans (Immunological Reviews (2006) 212, (28-50))

    M. G. Roncarolo;S. Gregori;M. Battaglia;R. Bacchetta

  • Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: Inconsistent correlation between forkhead box protein 3 expression and disease severity

    Eleonora Gambineri;Lucia Perroni;Laura Passerini;Lucia Bianchi

  • CD4+ T-regulatory cells: toward therapy for human diseases.

    Sarah E. Allan;Raewyn Broady;Silvia Gregori;Megan E. Himmel

  • CD4+ regulatory T cells: mechanisms of induction and effector function.

    Rosa Bacchetta;Silvia Gregori;Maria Grazia Roncarolo

  • Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

    Federica Barzaghi;Laura Cristina Amaya Hernandez;Benedicte Neven;Silvia Ricci

  • Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines.

    Rosa Bacchetta;Claudia Sartirana;Megan K. Levings;Claudio Bordignon

Frequent Co-Authors

Maria Grazia Roncarolo
Maria Grazia Roncarolo Stanford University
Silvia Gregori
Silvia Gregori Vita-Salute San Raffaele University
Megan K. Levings
Megan K. Levings University of British Columbia
Alessandro Aiuti
Alessandro Aiuti Vita-Salute San Raffaele University
Kari C. Nadeau
Kari C. Nadeau Harvard University
Caterina Cancrini
Caterina Cancrini Bambino Gesù Children's Hospital
Hervé Groux
Hervé Groux Grenoble Alpes University
Alice Bertaina
Alice Bertaina Stanford University
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Alessandro Plebani
Alessandro Plebani University of Brescia

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